AU2011245302A1 - Processes for preparing linezolid - Google Patents

Processes for preparing linezolid Download PDF

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Publication number
AU2011245302A1
AU2011245302A1 AU2011245302A AU2011245302A AU2011245302A1 AU 2011245302 A1 AU2011245302 A1 AU 2011245302A1 AU 2011245302 A AU2011245302 A AU 2011245302A AU 2011245302 A AU2011245302 A AU 2011245302A AU 2011245302 A1 AU2011245302 A1 AU 2011245302A1
Authority
AU
Australia
Prior art keywords
fluoro
mixing
compound
salt
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2011245302A
Other languages
English (en)
Inventor
James R. Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of AU2011245302A1 publication Critical patent/AU2011245302A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2011245302A 2010-04-30 2011-04-28 Processes for preparing linezolid Abandoned AU2011245302A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US32989210P 2010-04-30 2010-04-30
US61/329,892 2010-04-30
US35985110P 2010-06-30 2010-06-30
US61/359,851 2010-06-30
US37557610P 2010-08-20 2010-08-20
US61/375,576 2010-08-20
US38953410P 2010-10-04 2010-10-04
US61/389,534 2010-10-04
US42144210P 2010-12-09 2010-12-09
US61/421,442 2010-12-09
PCT/US2011/034278 WO2011137222A1 (en) 2010-04-30 2011-04-28 Processes for preparing linezolid

Publications (1)

Publication Number Publication Date
AU2011245302A1 true AU2011245302A1 (en) 2012-11-22

Family

ID=44861911

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011245302A Abandoned AU2011245302A1 (en) 2010-04-30 2011-04-28 Processes for preparing linezolid

Country Status (15)

Country Link
US (2) US9206141B2 (cg-RX-API-DMAC7.html)
EP (2) EP2899185B1 (cg-RX-API-DMAC7.html)
JP (1) JP5865898B2 (cg-RX-API-DMAC7.html)
KR (1) KR20130108975A (cg-RX-API-DMAC7.html)
CN (1) CN103025730A (cg-RX-API-DMAC7.html)
AU (1) AU2011245302A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012027901A2 (cg-RX-API-DMAC7.html)
CA (1) CA2798101A1 (cg-RX-API-DMAC7.html)
IL (1) IL222770A0 (cg-RX-API-DMAC7.html)
MX (1) MX2012012627A (cg-RX-API-DMAC7.html)
RU (1) RU2012151303A (cg-RX-API-DMAC7.html)
SG (1) SG185103A1 (cg-RX-API-DMAC7.html)
TW (1) TWI535715B (cg-RX-API-DMAC7.html)
WO (1) WO2011137222A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201208382B (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103025730A (zh) * 2010-04-30 2013-04-03 印第安纳大学研究及科技有限公司 制备利奈唑胺的方法
EP2595968B1 (en) 2011-02-24 2015-09-09 Lee Pharma Limited Novel process for preparation of linezolid and its novel intermediates
WO2013072923A1 (en) * 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
CN103254148B (zh) * 2012-02-15 2016-04-13 浙江海正药业股份有限公司 利奈唑胺中间体的制备方法
CN103288814B (zh) * 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法
EP2834235A1 (en) 2012-04-06 2015-02-11 Indiana University Research and Technology Corporation Processes for preparing rivaroxaban
ITMI20120655A1 (it) * 2012-04-19 2013-10-20 Bioindustria Lab Italiano M Edicinali Spa Procedimento per la preparazione di linezolid
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
CN103626712B (zh) * 2012-08-23 2016-06-01 重庆药友制药有限责任公司 一种用于制备利奈唑胺的中间体及其制备方法
WO2014045292A1 (en) * 2012-09-20 2014-03-27 Symed Labs Limited Improved process for the preparation of linezolid intermediate
WO2014170908A1 (en) * 2013-04-18 2014-10-23 Nosch Labs Private Limited Process for preparation of oxazolidinone derivatives
EP3250568A4 (en) * 2016-04-21 2018-08-01 Optimus Drugs Pvt Ltd An improved process for the preparation of linezolid
CN110194750A (zh) * 2019-06-19 2019-09-03 四川美大康华康药业有限公司 一种利奈唑胺的制备方法及精制方法
CN112159368A (zh) * 2020-07-07 2021-01-01 杭州杜易科技有限公司 一种利奈唑胺中间体的合成方法
RU2760198C1 (ru) * 2020-12-16 2021-11-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Однореакторный способ получения полупродукта для синтеза линезолида
CN115684399B (zh) * 2022-10-27 2024-12-20 贵州健安德科技有限公司 一种氯醇亚胺的高效液相检测及含量测定方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725450A (en) * 1970-10-05 1973-04-03 Gen Mills Chem Inc Process for the preparation of isocyanates from acyl azides
US4937331A (en) 1988-03-25 1990-06-26 President And Fellows Of Harvard College Chiral azetidinone epoxides
DE4119611A1 (de) * 1991-06-14 1992-12-17 Bayer Ag Mittel zur bekaempfung von schaedlingen auf basis substituierter oxazolidinone, neue substituierte oxazolidinone, deren herstellung und verwendung
TW380137B (en) * 1994-03-04 2000-01-21 Merck & Co Inc Process for making an epoxide
DE19542148A1 (de) * 1995-11-11 1997-05-15 Hoechst Ag Verfahren zur Herstellung von fluorierten Aromaten
NZ504372A (en) 1997-11-07 2002-12-20 Upjohn Co Process to produce N-[3-fluoro-4(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinones
US6921825B2 (en) 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
SE0001866D0 (sv) * 2000-05-18 2000-05-18 Astrazeneca Ab A new process
ATE321024T1 (de) 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
ATE338035T1 (de) 2001-06-05 2006-09-15 Boehringer Ingelheim Pharma 1,4-disubstituierte benzokondensierte cycloalkyl harnstoffverbindungen
ES2294494T3 (es) 2004-04-19 2008-04-01 Symed Labs Limited Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados.
EP1768967B1 (en) 2004-07-20 2009-04-22 Symed Labs Limited Novel intermediates for linezolid and related compounds
WO2006091731A2 (en) 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
WO2007011684A2 (en) 2005-07-15 2007-01-25 Cyclics Corporation Macrocyclic polyester oligomers as carriers and/or flow modifier additives for thermoplastics
AU2007235635A1 (en) 2006-04-07 2007-10-18 Pfizer Products Inc. Process for preparing linezolid
CN101220001A (zh) 2008-01-25 2008-07-16 浙江博泰化工有限公司 一种利奈唑酮的合成方法
CN101638392B (zh) 2009-08-24 2012-05-16 浙江工业大学 一种列奈唑酮的制备方法
CN103025730A (zh) * 2010-04-30 2013-04-03 印第安纳大学研究及科技有限公司 制备利奈唑胺的方法

Also Published As

Publication number Publication date
KR20130108975A (ko) 2013-10-07
EP2563781B1 (en) 2016-10-26
JP2013525454A (ja) 2013-06-20
JP5865898B2 (ja) 2016-02-17
EP2899185A1 (en) 2015-07-29
BR112012027901A2 (pt) 2015-09-08
US9656973B2 (en) 2017-05-23
CA2798101A1 (en) 2011-11-03
CN103025730A (zh) 2013-04-03
US9206141B2 (en) 2015-12-08
EP2563781A1 (en) 2013-03-06
EP2563781A4 (en) 2013-11-06
TWI535715B (zh) 2016-06-01
WO2011137222A1 (en) 2011-11-03
MX2012012627A (es) 2013-05-09
EP2899185B1 (en) 2018-01-31
ZA201208382B (en) 2015-06-24
TW201144301A (en) 2011-12-16
US20160024032A1 (en) 2016-01-28
RU2012151303A (ru) 2014-06-10
IL222770A0 (en) 2012-12-31
SG185103A1 (en) 2012-12-28
US20130053557A1 (en) 2013-02-28

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application