AU2010322478B2 - Benzoimidazole compounds and uses thereof - Google Patents

Benzoimidazole compounds and uses thereof Download PDF

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Publication number
AU2010322478B2
AU2010322478B2 AU2010322478A AU2010322478A AU2010322478B2 AU 2010322478 B2 AU2010322478 B2 AU 2010322478B2 AU 2010322478 A AU2010322478 A AU 2010322478A AU 2010322478 A AU2010322478 A AU 2010322478A AU 2010322478 B2 AU2010322478 B2 AU 2010322478B2
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AU
Australia
Prior art keywords
compound
salt
formula
animal
methyl
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Active
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AU2010322478A
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English (en)
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AU2010322478A1 (en
Inventor
Louis-David Cantin
Xuehong Luo
Miroslaw Jerzy Tomaszewski
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Glaxosmithkline Intellectual Property No 3 Ltd
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Glaxosmithkline Intellectual Property No 3 Ltd
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Publication of AU2010322478A1 publication Critical patent/AU2010322478A1/en
Assigned to NEOMED INSTITUTE reassignment NEOMED INSTITUTE Request for Assignment Assignors: ASTRAZENECA AB
Application granted granted Critical
Publication of AU2010322478B2 publication Critical patent/AU2010322478B2/en
Assigned to BELLUS HEALTH COUGH INC. reassignment BELLUS HEALTH COUGH INC. Request for Assignment Assignors: NEOMED INSTITUTE
Assigned to GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED reassignment GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED Request for Assignment Assignors: BELLUS HEALTH COUGH INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2010322478A 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof Active AU2010322478B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26226309P 2009-11-18 2009-11-18
US61/262,263 2009-11-18
PCT/SE2010/051269 WO2011062550A1 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Publications (2)

Publication Number Publication Date
AU2010322478A1 AU2010322478A1 (en) 2012-05-31
AU2010322478B2 true AU2010322478B2 (en) 2013-11-14

Family

ID=44059844

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010322478A Active AU2010322478B2 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Country Status (16)

Country Link
US (1) US8530467B2 (enExample)
EP (1) EP2501697B1 (enExample)
JP (1) JP5657018B2 (enExample)
KR (1) KR20120113709A (enExample)
CN (1) CN102741245B (enExample)
AR (1) AR079050A1 (enExample)
AU (1) AU2010322478B2 (enExample)
BR (1) BR112012011518B8 (enExample)
CA (1) CA2777746C (enExample)
ES (1) ES2442797T3 (enExample)
IN (1) IN2012DN03391A (enExample)
MX (1) MX2012005329A (enExample)
RU (1) RU2542582C2 (enExample)
TW (1) TW201121957A (enExample)
UY (1) UY33037A (enExample)
WO (1) WO2011062550A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158117A1 (en) * 2011-05-17 2012-11-22 Astrazeneca Ab Combination therapies for treating pain
WO2014117274A1 (en) * 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and uses thereof
JP6632127B2 (ja) * 2013-12-20 2020-01-15 塩野義製薬株式会社 トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物およびその中間体の製造方法
EP3981406A1 (en) * 2014-07-03 2022-04-13 Afferent Pharmaceuticals Inc. Methods and compositions for treating diseases and conditions
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators
CN108904507A (zh) * 2018-02-11 2018-11-30 赖英杰 P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用
SG11202106706TA (en) * 2018-12-29 2021-07-29 Wuhan Ll Science And Technology Development Co Ltd Heterocyclic compound intermediate, preparation method therefor and application thereof
CN113727716A (zh) 2019-02-25 2021-11-30 贝卢斯医疗咳嗽病公司 采用p2x3调节剂的治疗
WO2021161105A1 (en) * 2020-02-14 2021-08-19 Bellus Health Cough Inc. P2x3 modulators
WO2022033567A1 (zh) * 2020-08-13 2022-02-17 上海拓界生物医药科技有限公司 苯并咪唑类衍生物、其制备方法及医药用途
WO2022117062A1 (zh) * 2020-12-04 2022-06-09 上海拓界生物医药科技有限公司 含有稠合三环的化合物及其医药用途
CN114478508A (zh) * 2021-12-31 2022-05-13 淮北师范大学 一种苯并咪唑化合物的结晶形式
WO2023151658A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的可药用盐及其制备方法
CN118556054A (zh) * 2022-02-11 2024-08-27 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的结晶形式及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060264490A1 (en) * 2004-09-24 2006-11-23 Astrazeneca Ab Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I
WO2008108958A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Benzimidazole derivatives and methods of use thereof
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain

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US6026A (en) * 1849-01-09 Cast-iron car-wheel
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
WO1997030035A1 (en) 1996-02-13 1997-08-21 Zeneca Limited Quinazoline derivatives as vegf inhibitors
PT885198E (pt) 1996-03-05 2002-06-28 Astrazeneca Ab Derivados de 4-anilinoquinazolina
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BRPI0017548B8 (pt) 1999-02-10 2023-05-02 Astrazeneca Ab Composto
JP4059671B2 (ja) * 2000-01-17 2008-03-12 帝人株式会社 ベンズイミダゾール誘導体
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
MXPA02012905A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como agentes de dano vascular..
BR0112225A (pt) 2000-07-07 2003-05-06 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060264490A1 (en) * 2004-09-24 2006-11-23 Astrazeneca Ab Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I
WO2008108958A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Benzimidazole derivatives and methods of use thereof
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain

Also Published As

Publication number Publication date
WO2011062550A1 (en) 2011-05-26
US8530467B2 (en) 2013-09-10
IN2012DN03391A (enExample) 2015-10-23
ES2442797T3 (es) 2014-02-13
AR079050A1 (es) 2011-12-21
JP2013511517A (ja) 2013-04-04
BR112012011518B8 (pt) 2023-01-10
MX2012005329A (es) 2012-05-29
CA2777746C (en) 2019-05-14
EP2501697A4 (en) 2013-04-24
RU2542582C2 (ru) 2015-02-20
KR20120113709A (ko) 2012-10-15
CN102741245A (zh) 2012-10-17
US20120289504A1 (en) 2012-11-15
EP2501697B1 (en) 2013-10-23
AU2010322478A1 (en) 2012-05-31
TW201121957A (en) 2011-07-01
CA2777746A1 (en) 2011-05-26
JP5657018B2 (ja) 2015-01-21
RU2012124268A (ru) 2013-12-27
UY33037A (es) 2011-06-30
CN102741245B (zh) 2014-11-05
BR112012011518A2 (pt) 2016-06-28
BR112012011518B1 (pt) 2020-03-10
EP2501697A1 (en) 2012-09-26

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Owner name: BELLUS HEALTH COUGH INC.

Free format text: FORMER OWNER(S): NEOMED INSTITUTE

PC Assignment registered

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED

Free format text: FORMER OWNER(S): BELLUS HEALTH COUGH INC.