CA2777746C - Benzoimidazole compounds and uses thereof - Google Patents
Benzoimidazole compounds and uses thereof Download PDFInfo
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- CA2777746C CA2777746C CA2777746A CA2777746A CA2777746C CA 2777746 C CA2777746 C CA 2777746C CA 2777746 A CA2777746 A CA 2777746A CA 2777746 A CA2777746 A CA 2777746A CA 2777746 C CA2777746 C CA 2777746C
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- 150000001875 compounds Chemical class 0.000 claims abstract description 167
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- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- 229960002791 zimeldine Drugs 0.000 description 1
- OYPPVKRFBIWMSX-SXGWCWSVSA-N zimeldine Chemical compound C=1C=CN=CC=1C(=C/CN(C)C)\C1=CC=C(Br)C=C1 OYPPVKRFBIWMSX-SXGWCWSVSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960001366 zolazepam Drugs 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26226309P | 2009-11-18 | 2009-11-18 | |
| US61/262,263 | 2009-11-18 | ||
| PCT/SE2010/051269 WO2011062550A1 (en) | 2009-11-18 | 2010-11-17 | Benzoimidazole compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2777746A1 CA2777746A1 (en) | 2011-05-26 |
| CA2777746C true CA2777746C (en) | 2019-05-14 |
Family
ID=44059844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2777746A Active CA2777746C (en) | 2009-11-18 | 2010-11-17 | Benzoimidazole compounds and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8530467B2 (enExample) |
| EP (1) | EP2501697B1 (enExample) |
| JP (1) | JP5657018B2 (enExample) |
| KR (1) | KR20120113709A (enExample) |
| CN (1) | CN102741245B (enExample) |
| AR (1) | AR079050A1 (enExample) |
| AU (1) | AU2010322478B2 (enExample) |
| BR (1) | BR112012011518B8 (enExample) |
| CA (1) | CA2777746C (enExample) |
| ES (1) | ES2442797T3 (enExample) |
| IN (1) | IN2012DN03391A (enExample) |
| MX (1) | MX2012005329A (enExample) |
| RU (1) | RU2542582C2 (enExample) |
| TW (1) | TW201121957A (enExample) |
| UY (1) | UY33037A (enExample) |
| WO (1) | WO2011062550A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158117A1 (en) * | 2011-05-17 | 2012-11-22 | Astrazeneca Ab | Combination therapies for treating pain |
| US9598409B2 (en) * | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| CN105992761A (zh) * | 2013-12-20 | 2016-10-05 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法 |
| US10195198B2 (en) | 2014-07-03 | 2019-02-05 | Afferent Pharmaceuticals, Inc. | Methods and compositions for treating diseases and conditions |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| CN108904507A (zh) * | 2018-02-11 | 2018-11-30 | 赖英杰 | P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用 |
| SG11202106706TA (en) * | 2018-12-29 | 2021-07-29 | Wuhan Ll Science And Technology Development Co Ltd | Heterocyclic compound intermediate, preparation method therefor and application thereof |
| EP3930722A4 (en) * | 2019-02-25 | 2022-12-28 | Bellus Health Cough Inc. | TREATMENT WITH P2X3 MODULATORS |
| CN119039290A (zh) * | 2020-02-14 | 2024-11-29 | 葛兰素史密斯克莱知识产权(第3号)有限公司 | P2x3调节剂 |
| JP2023536986A (ja) * | 2020-08-13 | 2023-08-30 | 上海拓界生物医薬科技有限公司 | ベンズイミダゾール誘導体、その調製方法及び医薬用途 |
| TW202227458A (zh) * | 2020-12-04 | 2022-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | 含有稠合三環的化合物及其醫藥用途 |
| CN114478508A (zh) * | 2021-12-31 | 2022-05-13 | 淮北师范大学 | 一种苯并咪唑化合物的结晶形式 |
| CN118556054A (zh) * | 2022-02-11 | 2024-08-27 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的结晶形式及其制备方法 |
| WO2023151658A1 (zh) * | 2022-02-11 | 2023-08-17 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的可药用盐及其制备方法 |
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| US6026A (en) * | 1849-01-09 | Cast-iron car-wheel | ||
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
| IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EE05708B1 (et) | 1999-02-10 | 2014-04-15 | Astrazeneca Ab | Kinasoliini derivaat angiogeneesi inhibiitorina ja selle kasutamine |
| KR100763779B1 (ko) * | 2000-01-17 | 2007-10-05 | 데이진 가부시키가이샤 | 벤즈이미다졸 유도체 |
| JP2003535078A (ja) | 2000-05-31 | 2003-11-25 | アストラゼネカ アクチボラグ | 血管損傷活性のあるインドール誘導体 |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| RU2003103603A (ru) | 2000-07-07 | 2004-08-20 | Энджиоджен Фармасьютикалз Лимитед (Gb) | Производные колхинола в качестве ингибиторов ангиогенеза |
| CA2411160A1 (en) | 2000-07-07 | 2002-01-17 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| ATE545644T1 (de) * | 2004-09-24 | 2012-03-15 | Astrazeneca Ab | Benzimidazolderivate, diese enthaltende zusammensetzungen, herstellung davon und anwendungen davon i |
| TW200843756A (en) * | 2007-03-02 | 2008-11-16 | Schering Corp | Benzimidazole derivatives and methods of use thereof |
| US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
-
2010
- 2010-11-17 TW TW099139607A patent/TW201121957A/zh unknown
- 2010-11-17 AR ARP100104240A patent/AR079050A1/es unknown
- 2010-11-17 RU RU2012124268/04A patent/RU2542582C2/ru active
- 2010-11-17 BR BR112012011518A patent/BR112012011518B8/pt active IP Right Grant
- 2010-11-17 ES ES10831876.7T patent/ES2442797T3/es active Active
- 2010-11-17 CN CN201080061596.6A patent/CN102741245B/zh active Active
- 2010-11-17 KR KR1020127012726A patent/KR20120113709A/ko not_active Withdrawn
- 2010-11-17 AU AU2010322478A patent/AU2010322478B2/en active Active
- 2010-11-17 CA CA2777746A patent/CA2777746C/en active Active
- 2010-11-17 EP EP10831876.7A patent/EP2501697B1/en active Active
- 2010-11-17 JP JP2012539853A patent/JP5657018B2/ja active Active
- 2010-11-17 WO PCT/SE2010/051269 patent/WO2011062550A1/en not_active Ceased
- 2010-11-17 MX MX2012005329A patent/MX2012005329A/es active IP Right Grant
- 2010-11-17 IN IN3391DEN2012 patent/IN2012DN03391A/en unknown
- 2010-11-18 UY UY0001033037A patent/UY33037A/es not_active Application Discontinuation
-
2012
- 2012-05-16 US US13/472,825 patent/US8530467B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012011518B8 (pt) | 2023-01-10 |
| UY33037A (es) | 2011-06-30 |
| JP2013511517A (ja) | 2013-04-04 |
| CN102741245B (zh) | 2014-11-05 |
| ES2442797T3 (es) | 2014-02-13 |
| IN2012DN03391A (enExample) | 2015-10-23 |
| KR20120113709A (ko) | 2012-10-15 |
| CA2777746A1 (en) | 2011-05-26 |
| US8530467B2 (en) | 2013-09-10 |
| RU2542582C2 (ru) | 2015-02-20 |
| BR112012011518A2 (pt) | 2016-06-28 |
| JP5657018B2 (ja) | 2015-01-21 |
| MX2012005329A (es) | 2012-05-29 |
| EP2501697A4 (en) | 2013-04-24 |
| US20120289504A1 (en) | 2012-11-15 |
| AU2010322478A1 (en) | 2012-05-31 |
| CN102741245A (zh) | 2012-10-17 |
| WO2011062550A1 (en) | 2011-05-26 |
| AU2010322478B2 (en) | 2013-11-14 |
| TW201121957A (en) | 2011-07-01 |
| EP2501697B1 (en) | 2013-10-23 |
| RU2012124268A (ru) | 2013-12-27 |
| EP2501697A1 (en) | 2012-09-26 |
| BR112012011518B1 (pt) | 2020-03-10 |
| AR079050A1 (es) | 2011-12-21 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20161025 |