UY33037A - Compuestos benzoimidazólicos y sus usos - Google Patents

Compuestos benzoimidazólicos y sus usos

Info

Publication number
UY33037A
UY33037A UY0001033037A UY33037A UY33037A UY 33037 A UY33037 A UY 33037A UY 0001033037 A UY0001033037 A UY 0001033037A UY 33037 A UY33037 A UY 33037A UY 33037 A UY33037 A UY 33037A
Authority
UY
Uruguay
Prior art keywords
compound
methyl
compounds
benzoimidazolic
processes
Prior art date
Application number
UY0001033037A
Other languages
English (en)
Inventor
Miroslaw Jerzy Tomaszewski
Louis-David Cantin
Luo Xuehong
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY33037A publication Critical patent/UY33037A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere en general a compuestos benzoimidazólicos sustituidos, particularmente 2-((2-(2,6-difluoro-4-(metilcarbamoil)fenil)-5-metil-1H-benzo[d]imidazol-1-il)metil)morfolin-4-carboxilato de metilo y sus sales. Esta invención también se refiere a composiciones farmacéuticas y a kits que comprenden un compuesto de este tipo, a los usos de un compuesto de este tipo (incluidos, por ejemplo, los métodos de tratamiento y los preparados farmacéuticos), a los procesos para fabricar un compuesto de este tipo y a los intermedios empleados en tales procesos.
UY0001033037A 2009-11-18 2010-11-18 Compuestos benzoimidazólicos y sus usos UY33037A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26226309P 2009-11-18 2009-11-18

Publications (1)

Publication Number Publication Date
UY33037A true UY33037A (es) 2011-06-30

Family

ID=44059844

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033037A UY33037A (es) 2009-11-18 2010-11-18 Compuestos benzoimidazólicos y sus usos

Country Status (16)

Country Link
US (1) US8530467B2 (es)
EP (1) EP2501697B1 (es)
JP (1) JP5657018B2 (es)
KR (1) KR20120113709A (es)
CN (1) CN102741245B (es)
AR (1) AR079050A1 (es)
AU (1) AU2010322478B2 (es)
BR (1) BR112012011518B8 (es)
CA (1) CA2777746C (es)
ES (1) ES2442797T3 (es)
IN (1) IN2012DN03391A (es)
MX (1) MX2012005329A (es)
RU (1) RU2542582C2 (es)
TW (1) TW201121957A (es)
UY (1) UY33037A (es)
WO (1) WO2011062550A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158117A1 (en) * 2011-05-17 2012-11-22 Astrazeneca Ab Combination therapies for treating pain
CN105246888B (zh) 2013-01-31 2017-09-05 尼奥迈德研究所 咪唑并吡啶化合物及其用途
CN105992761A (zh) * 2013-12-20 2016-10-05 盐野义制药株式会社 具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法
EP3164132A4 (en) 2014-07-03 2018-02-21 Afferent Pharmaceuticals Inc. Methods and compositions for treating diseases and conditions
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators
CN108904507A (zh) * 2018-02-11 2018-11-30 赖英杰 P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用
JP2022515879A (ja) * 2018-12-29 2022-02-22 武漢朗来科技発展有限公司 複素環式化合物、中間体、その製造方法及び応用 本願は、出願日が２０１８年１２月２９日の中国特許出願ｃｎ ２０１８１１６４２３１９、出願日が２０１９年０５月２４日の中国特許出願ｃｎ２０１９１０４４０２１４．３及び出願日が２０１９年１０月２４日の中国特許出願ｃｎ２０１９１１０１６１５８．７に基づいて優先権を主張する。また、上記中国特許出願の全文は本願に援用される。
KR20230051209A (ko) * 2020-08-13 2023-04-17 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 벤즈이미다졸 유도체, 이의 제조 방법 및 이의 의학적 용도
WO2022117062A1 (zh) * 2020-12-04 2022-06-09 上海拓界生物医药科技有限公司 含有稠合三环的化合物及其医药用途
CN114478508A (zh) * 2021-12-31 2022-05-13 淮北师范大学 一种苯并咪唑化合物的结晶形式
WO2023151658A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的可药用盐及其制备方法
WO2023151660A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的结晶形式及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6026A (en) * 1849-01-09 Cast-iron car-wheel
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
WO1997030035A1 (en) 1996-02-13 1997-08-21 Zeneca Limited Quinazoline derivatives as vegf inhibitors
WO1997032856A1 (en) 1996-03-05 1997-09-12 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
SK288365B6 (sk) 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
DE60130865T2 (de) * 2000-01-17 2008-07-17 Teijin Pharma Ltd. Benzimidazol-derivate als menschliche chymase - inhibitoren
CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
NZ522661A (en) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
AU2001266233B2 (en) 2000-07-07 2006-06-29 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
KR101269869B1 (ko) * 2004-09-24 2013-06-07 네오메드 인스티튜트 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도
CN101674827A (zh) * 2007-03-02 2010-03-17 先灵公司 苯并咪唑衍生物及其使用方法
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
AU2008319308B2 (en) * 2007-10-31 2013-01-31 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain

Also Published As

Publication number Publication date
TW201121957A (en) 2011-07-01
JP5657018B2 (ja) 2015-01-21
MX2012005329A (es) 2012-05-29
JP2013511517A (ja) 2013-04-04
ES2442797T3 (es) 2014-02-13
EP2501697A1 (en) 2012-09-26
WO2011062550A1 (en) 2011-05-26
RU2542582C2 (ru) 2015-02-20
IN2012DN03391A (es) 2015-10-23
CN102741245A (zh) 2012-10-17
AR079050A1 (es) 2011-12-21
EP2501697B1 (en) 2013-10-23
BR112012011518B8 (pt) 2023-01-10
BR112012011518B1 (pt) 2020-03-10
RU2012124268A (ru) 2013-12-27
BR112012011518A2 (pt) 2016-06-28
CA2777746C (en) 2019-05-14
AU2010322478A1 (en) 2012-05-31
AU2010322478B2 (en) 2013-11-14
KR20120113709A (ko) 2012-10-15
US20120289504A1 (en) 2012-11-15
US8530467B2 (en) 2013-09-10
CN102741245B (zh) 2014-11-05
EP2501697A4 (en) 2013-04-24
CA2777746A1 (en) 2011-05-26

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20181127