RU2542582C2 - Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 - Google Patents
Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 Download PDFInfo
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- RU2542582C2 RU2542582C2 RU2012124268/04A RU2012124268A RU2542582C2 RU 2542582 C2 RU2542582 C2 RU 2542582C2 RU 2012124268/04 A RU2012124268/04 A RU 2012124268/04A RU 2012124268 A RU2012124268 A RU 2012124268A RU 2542582 C2 RU2542582 C2 RU 2542582C2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US26226309P | 2009-11-18 | 2009-11-18 | |
| US61/262,263 | 2009-11-18 | ||
| PCT/SE2010/051269 WO2011062550A1 (en) | 2009-11-18 | 2010-11-17 | Benzoimidazole compounds and uses thereof |
Publications (2)
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| RU2012124268A RU2012124268A (ru) | 2013-12-27 |
| RU2542582C2 true RU2542582C2 (ru) | 2015-02-20 |
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| EP (1) | EP2501697B1 (enExample) |
| JP (1) | JP5657018B2 (enExample) |
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| CN (1) | CN102741245B (enExample) |
| AR (1) | AR079050A1 (enExample) |
| AU (1) | AU2010322478B2 (enExample) |
| BR (1) | BR112012011518B8 (enExample) |
| CA (1) | CA2777746C (enExample) |
| ES (1) | ES2442797T3 (enExample) |
| IN (1) | IN2012DN03391A (enExample) |
| MX (1) | MX2012005329A (enExample) |
| RU (1) | RU2542582C2 (enExample) |
| TW (1) | TW201121957A (enExample) |
| UY (1) | UY33037A (enExample) |
| WO (1) | WO2011062550A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012158117A1 (en) * | 2011-05-17 | 2012-11-22 | Astrazeneca Ab | Combination therapies for treating pain |
| EP3381917B1 (en) * | 2013-01-31 | 2021-09-08 | Bellus Health Cough Inc. | Imidazopyridine compounds and uses thereof |
| JP6632127B2 (ja) * | 2013-12-20 | 2020-01-15 | 塩野義製薬株式会社 | トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物およびその中間体の製造方法 |
| EP3164132A4 (en) * | 2014-07-03 | 2018-02-21 | Afferent Pharmaceuticals Inc. | Methods and compositions for treating diseases and conditions |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| CN108904507A (zh) * | 2018-02-11 | 2018-11-30 | 赖英杰 | P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用 |
| JP2022515879A (ja) * | 2018-12-29 | 2022-02-22 | 武漢朗来科技発展有限公司 | 複素環式化合物、中間体、その製造方法及び応用 本願は、出願日が２０１８年１２月２９日の中国特許出願ｃｎ ２０１８１１６４２３１９、出願日が２０１９年０５月２４日の中国特許出願ｃｎ２０１９１０４４０２１４．３及び出願日が２０１９年１０月２４日の中国特許出願ｃｎ２０１９１１０１６１５８．７に基づいて優先権を主張する。また、上記中国特許出願の全文は本願に援用される。 |
| AU2020228760A1 (en) | 2019-02-25 | 2021-09-23 | Glaxosmithkline Intellectual Property (No. 3) Limited | Treatment with P2X3 modulators |
| IL295393A (en) * | 2020-02-14 | 2022-10-01 | Bellus Health Cough Inc | P2x3 modulators |
| CA3187092A1 (en) * | 2020-08-13 | 2022-02-17 | Wenming Li | Benzimidazole derivatives, preparation method therefor and medical use thereof |
| TW202227458A (zh) * | 2020-12-04 | 2022-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | 含有稠合三環的化合物及其醫藥用途 |
| CN114478508A (zh) * | 2021-12-31 | 2022-05-13 | 淮北师范大学 | 一种苯并咪唑化合物的结晶形式 |
| CN118556054A (zh) * | 2022-02-11 | 2024-08-27 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的结晶形式及其制备方法 |
| WO2023151658A1 (zh) * | 2022-02-11 | 2023-08-17 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的可药用盐及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2263674C2 (ru) * | 2000-01-17 | 2005-11-10 | Тейдзин Лимитед | Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе |
| US20060264490A1 (en) * | 2004-09-24 | 2006-11-23 | Astrazeneca Ab | Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I |
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| US6026A (en) * | 1849-01-09 | Cast-iron car-wheel | ||
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| AU719434B2 (en) | 1996-02-13 | 2000-05-11 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
| AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| CA2674803C (en) | 1999-02-10 | 2012-10-09 | Astrazeneca Ab | Quinazoline derivatives as angiogenesis inhibitors |
| CA2406979A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| AU2001266233B2 (en) | 2000-07-07 | 2006-06-29 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
| AR065495A1 (es) * | 2007-03-02 | 2009-06-10 | Schering Corp | Metodos para usar derivados de bencimidazol para tratar o prevenir dolor, diabetes, complicacion diabetica composiciones. |
| US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
| AU2008319308B2 (en) * | 2007-10-31 | 2013-01-31 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
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2010
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2263674C2 (ru) * | 2000-01-17 | 2005-11-10 | Тейдзин Лимитед | Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе |
| US20060264490A1 (en) * | 2004-09-24 | 2006-11-23 | Astrazeneca Ab | Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012124268A (ru) | 2013-12-27 |
| CA2777746C (en) | 2019-05-14 |
| UY33037A (es) | 2011-06-30 |
| BR112012011518A2 (pt) | 2016-06-28 |
| ES2442797T3 (es) | 2014-02-13 |
| WO2011062550A1 (en) | 2011-05-26 |
| AU2010322478A1 (en) | 2012-05-31 |
| CN102741245A (zh) | 2012-10-17 |
| JP2013511517A (ja) | 2013-04-04 |
| MX2012005329A (es) | 2012-05-29 |
| KR20120113709A (ko) | 2012-10-15 |
| EP2501697A1 (en) | 2012-09-26 |
| IN2012DN03391A (enExample) | 2015-10-23 |
| AR079050A1 (es) | 2011-12-21 |
| AU2010322478B2 (en) | 2013-11-14 |
| JP5657018B2 (ja) | 2015-01-21 |
| TW201121957A (en) | 2011-07-01 |
| US20120289504A1 (en) | 2012-11-15 |
| BR112012011518B1 (pt) | 2020-03-10 |
| BR112012011518B8 (pt) | 2023-01-10 |
| CA2777746A1 (en) | 2011-05-26 |
| US8530467B2 (en) | 2013-09-10 |
| CN102741245B (zh) | 2014-11-05 |
| EP2501697A4 (en) | 2013-04-24 |
| EP2501697B1 (en) | 2013-10-23 |
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