RU2542582C2 - Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 - Google Patents
Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 Download PDFInfo
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- RU2542582C2 RU2542582C2 RU2012124268/04A RU2012124268A RU2542582C2 RU 2542582 C2 RU2542582 C2 RU 2542582C2 RU 2012124268/04 A RU2012124268/04 A RU 2012124268/04A RU 2012124268 A RU2012124268 A RU 2012124268A RU 2542582 C2 RU2542582 C2 RU 2542582C2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26226309P | 2009-11-18 | 2009-11-18 | |
| US61/262,263 | 2009-11-18 | ||
| PCT/SE2010/051269 WO2011062550A1 (en) | 2009-11-18 | 2010-11-17 | Benzoimidazole compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012124268A RU2012124268A (ru) | 2013-12-27 |
| RU2542582C2 true RU2542582C2 (ru) | 2015-02-20 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| RU2012124268/04A RU2542582C2 (ru) | 2009-11-18 | 2010-11-17 | Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 |
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| EP (1) | EP2501697B1 (enExample) |
| JP (1) | JP5657018B2 (enExample) |
| KR (1) | KR20120113709A (enExample) |
| CN (1) | CN102741245B (enExample) |
| AR (1) | AR079050A1 (enExample) |
| AU (1) | AU2010322478B2 (enExample) |
| BR (1) | BR112012011518B8 (enExample) |
| CA (1) | CA2777746C (enExample) |
| ES (1) | ES2442797T3 (enExample) |
| IN (1) | IN2012DN03391A (enExample) |
| MX (1) | MX2012005329A (enExample) |
| RU (1) | RU2542582C2 (enExample) |
| TW (1) | TW201121957A (enExample) |
| UY (1) | UY33037A (enExample) |
| WO (1) | WO2011062550A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158117A1 (en) * | 2011-05-17 | 2012-11-22 | Astrazeneca Ab | Combination therapies for treating pain |
| US9598409B2 (en) * | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| CN105992761A (zh) * | 2013-12-20 | 2016-10-05 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法 |
| US10195198B2 (en) | 2014-07-03 | 2019-02-05 | Afferent Pharmaceuticals, Inc. | Methods and compositions for treating diseases and conditions |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| CN108904507A (zh) * | 2018-02-11 | 2018-11-30 | 赖英杰 | P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用 |
| SG11202106706TA (en) * | 2018-12-29 | 2021-07-29 | Wuhan Ll Science And Technology Development Co Ltd | Heterocyclic compound intermediate, preparation method therefor and application thereof |
| EP3930722A4 (en) * | 2019-02-25 | 2022-12-28 | Bellus Health Cough Inc. | TREATMENT WITH P2X3 MODULATORS |
| CN119039290A (zh) * | 2020-02-14 | 2024-11-29 | 葛兰素史密斯克莱知识产权(第3号)有限公司 | P2x3调节剂 |
| JP2023536986A (ja) * | 2020-08-13 | 2023-08-30 | 上海拓界生物医薬科技有限公司 | ベンズイミダゾール誘導体、その調製方法及び医薬用途 |
| TW202227458A (zh) * | 2020-12-04 | 2022-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | 含有稠合三環的化合物及其醫藥用途 |
| CN114478508A (zh) * | 2021-12-31 | 2022-05-13 | 淮北师范大学 | 一种苯并咪唑化合物的结晶形式 |
| CN118556054A (zh) * | 2022-02-11 | 2024-08-27 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的结晶形式及其制备方法 |
| WO2023151658A1 (zh) * | 2022-02-11 | 2023-08-17 | 江苏恒瑞医药股份有限公司 | 一种p2x3受体拮抗剂的可药用盐及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2263674C2 (ru) * | 2000-01-17 | 2005-11-10 | Тейдзин Лимитед | Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе |
| US20060264490A1 (en) * | 2004-09-24 | 2006-11-23 | Astrazeneca Ab | Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6026A (en) * | 1849-01-09 | Cast-iron car-wheel | ||
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
| IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EE05708B1 (et) | 1999-02-10 | 2014-04-15 | Astrazeneca Ab | Kinasoliini derivaat angiogeneesi inhibiitorina ja selle kasutamine |
| JP2003535078A (ja) | 2000-05-31 | 2003-11-25 | アストラゼネカ アクチボラグ | 血管損傷活性のあるインドール誘導体 |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| RU2003103603A (ru) | 2000-07-07 | 2004-08-20 | Энджиоджен Фармасьютикалз Лимитед (Gb) | Производные колхинола в качестве ингибиторов ангиогенеза |
| CA2411160A1 (en) | 2000-07-07 | 2002-01-17 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
| TW200843756A (en) * | 2007-03-02 | 2008-11-16 | Schering Corp | Benzimidazole derivatives and methods of use thereof |
| US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
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2010
- 2010-11-17 TW TW099139607A patent/TW201121957A/zh unknown
- 2010-11-17 AR ARP100104240A patent/AR079050A1/es unknown
- 2010-11-17 RU RU2012124268/04A patent/RU2542582C2/ru active
- 2010-11-17 BR BR112012011518A patent/BR112012011518B8/pt active IP Right Grant
- 2010-11-17 ES ES10831876.7T patent/ES2442797T3/es active Active
- 2010-11-17 CN CN201080061596.6A patent/CN102741245B/zh active Active
- 2010-11-17 KR KR1020127012726A patent/KR20120113709A/ko not_active Withdrawn
- 2010-11-17 AU AU2010322478A patent/AU2010322478B2/en active Active
- 2010-11-17 CA CA2777746A patent/CA2777746C/en active Active
- 2010-11-17 EP EP10831876.7A patent/EP2501697B1/en active Active
- 2010-11-17 JP JP2012539853A patent/JP5657018B2/ja active Active
- 2010-11-17 WO PCT/SE2010/051269 patent/WO2011062550A1/en not_active Ceased
- 2010-11-17 MX MX2012005329A patent/MX2012005329A/es active IP Right Grant
- 2010-11-17 IN IN3391DEN2012 patent/IN2012DN03391A/en unknown
- 2010-11-18 UY UY0001033037A patent/UY33037A/es not_active Application Discontinuation
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2012
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2263674C2 (ru) * | 2000-01-17 | 2005-11-10 | Тейдзин Лимитед | Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе |
| US20060264490A1 (en) * | 2004-09-24 | 2006-11-23 | Astrazeneca Ab | Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I |
Also Published As
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|---|---|
| BR112012011518B8 (pt) | 2023-01-10 |
| UY33037A (es) | 2011-06-30 |
| JP2013511517A (ja) | 2013-04-04 |
| CN102741245B (zh) | 2014-11-05 |
| ES2442797T3 (es) | 2014-02-13 |
| IN2012DN03391A (enExample) | 2015-10-23 |
| KR20120113709A (ko) | 2012-10-15 |
| CA2777746A1 (en) | 2011-05-26 |
| US8530467B2 (en) | 2013-09-10 |
| BR112012011518A2 (pt) | 2016-06-28 |
| JP5657018B2 (ja) | 2015-01-21 |
| CA2777746C (en) | 2019-05-14 |
| MX2012005329A (es) | 2012-05-29 |
| EP2501697A4 (en) | 2013-04-24 |
| US20120289504A1 (en) | 2012-11-15 |
| AU2010322478A1 (en) | 2012-05-31 |
| CN102741245A (zh) | 2012-10-17 |
| WO2011062550A1 (en) | 2011-05-26 |
| AU2010322478B2 (en) | 2013-11-14 |
| TW201121957A (en) | 2011-07-01 |
| EP2501697B1 (en) | 2013-10-23 |
| RU2012124268A (ru) | 2013-12-27 |
| EP2501697A1 (en) | 2012-09-26 |
| BR112012011518B1 (pt) | 2020-03-10 |
| AR079050A1 (es) | 2011-12-21 |
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