AU2008293513B2 - Method for producing viral vaccines - Google Patents
Method for producing viral vaccines Download PDFInfo
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- AU2008293513B2 AU2008293513B2 AU2008293513A AU2008293513A AU2008293513B2 AU 2008293513 B2 AU2008293513 B2 AU 2008293513B2 AU 2008293513 A AU2008293513 A AU 2008293513A AU 2008293513 A AU2008293513 A AU 2008293513A AU 2008293513 B2 AU2008293513 B2 AU 2008293513B2
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/06—Inactivation or attenuation by chemical treatment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16261—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
- Oncology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- AIDS & HIV (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
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| AU2008293513A1 AU2008293513A1 (en) | 2009-03-05 |
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| JP (1) | JP5535910B2 (enExample) |
| KR (1) | KR101760844B1 (enExample) |
| CN (1) | CN101790381B (enExample) |
| AU (1) | AU2008293513B2 (enExample) |
| BR (1) | BRPI0816130A2 (enExample) |
| CA (1) | CA2696090C (enExample) |
| ES (1) | ES2459166T3 (enExample) |
| HR (1) | HRP20140375T1 (enExample) |
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| PL (1) | PL2192917T3 (enExample) |
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| SG (1) | SG10201404101RA (enExample) |
| SI (1) | SI2192917T1 (enExample) |
| WO (1) | WO2009029695A1 (enExample) |
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| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EA014028B1 (ru) * | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
| CN101784283A (zh) * | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| WO2011005772A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| GB0918830D0 (en) | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
| ES2562818T3 (es) * | 2010-05-03 | 2016-03-08 | Glaxosmithkline Biologicals S.A. | Procedimiento de inactivación del virus de la gripe |
| JP6119030B2 (ja) | 2010-07-06 | 2017-04-26 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | インフルエンザを治療するための組成物及び方法 |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| US20130323280A1 (en) | 2011-01-13 | 2013-12-05 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| ES2653197T3 (es) * | 2011-07-20 | 2018-02-06 | Bgp Products B.V. | Procedimiento para producir antígeno ortomixoviral y vacunas |
| PT2737060T (pt) * | 2011-07-27 | 2019-06-05 | Flash Therapeutics | Método para a produção de partículas retrovirais úteis para transdução de células eucarióticas |
| CA2890084C (en) | 2011-11-18 | 2021-05-04 | Maura Ellen Campbell | Synthetic derivatives of mpl and uses thereof |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| US10125402B2 (en) * | 2013-10-22 | 2018-11-13 | Roche Molecular Systems, Inc. | Method for measuring cell-free virus particles from dried blood spots |
| FR3025107B1 (fr) * | 2014-08-29 | 2018-10-05 | Calixar | Procede de preparation d'un antigene vaccinal, antigene vaccinal obtenu et utilisations |
| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| CN111979120B (zh) * | 2019-05-23 | 2022-09-27 | 比欧联科供应链管理(北京)有限公司 | 一种狂犬疫苗核酸消化去除装置及实验方法 |
| RU2754398C1 (ru) * | 2020-06-25 | 2021-09-01 | Общество с ограниченной ответственностью «ФОРТ» | Способ получения четырехвалентной вакцины для профилактики гриппа |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1498261A (en) * | 1974-01-14 | 1978-01-18 | Sandoz Ltd | Influenza vaccines |
| EP0514199A2 (en) * | 1991-05-17 | 1992-11-19 | Retroscreen Limited | Vaccines and methods for their production |
| WO2000035481A2 (en) * | 1998-12-17 | 2000-06-22 | Connaught Laboratories Limited | Multivalent immunogenic composition containing rsv subunit composition and influenza virus preparation |
| US6136321A (en) * | 1997-02-24 | 2000-10-24 | Baxter Aktiengesellschaft | Method of inactivating lipid-enveloped viruses |
| WO2002097072A2 (en) * | 2001-05-30 | 2002-12-05 | Saechsisches Serumwerk Dresden Branch Of Smithkline Beecham Pharma Gmbh & Co. Kg | Influenza vaccine composition |
| US20040022808A1 (en) * | 2000-10-02 | 2004-02-05 | Colau Brigitte Desire Alberte | Vaccine |
| EP1724338A1 (en) * | 2005-05-19 | 2006-11-22 | Crucell Holland B.V. | Methods for the production of a whole-inactivated West Nile Virus vaccine |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2475572A1 (fr) | 1980-02-11 | 1981-08-14 | Pasteur Institut | Procede pour l'obtention de fragments de virus a enveloppe lipidique, en particulier d'antigenes utilisables comme vaccins, produits obtenus et applications |
| FR2533548B1 (fr) * | 1982-09-28 | 1985-07-26 | Degremont | Procede et appareil de traitement anaerobie d'eaux residuaires dans un filtre a remplissage de materiau granulaire |
| EP0172433A3 (en) * | 1984-08-02 | 1989-04-05 | Tektronix, Inc. | Display method and apparatus employing cursor panning |
| RU2082433C1 (ru) * | 1992-07-13 | 1997-06-27 | Николай Владимирович Костючек | Способ вакцинопрофилактики гриппа |
| FR2723740B1 (fr) | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
| CN1223589A (zh) * | 1996-05-06 | 1999-07-21 | 美国拜尔公司 | 包含鹦鹉热衣原体的猫疫苗及其制备方法 |
| CN1618464A (zh) * | 1998-10-05 | 2005-05-25 | 财团法人阪大微生物病研究会 | 用于抗日本脑炎病毒感染的灭活疫苗的增强免疫原及其生产方法 |
| US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| AR035651A1 (es) | 2000-07-28 | 2004-06-23 | Univ Madrid Complutense | Uso de derivados de indol para la manufactura de un medicamento para reducir la presion intraocular y una composicion |
| RU2195959C1 (ru) * | 2001-11-02 | 2003-01-10 | Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных | Инактивированная вакцина против синдрома гидроперикардита кур |
| RU2261111C1 (ru) * | 2004-04-08 | 2005-09-27 | Сергеев Виталий Александрович | Инактивированная вакцина против вирусных пневмогастроэнтеритов крупного рогатого скота и телят и способ профилактики вирусных пневмогастроэнтеритов |
| US8703467B2 (en) | 2004-05-27 | 2014-04-22 | Baxter International Inc. | Inactivation of a pathogen in a sample by a treatment with formalin and UV light |
| CN1647822A (zh) * | 2005-02-06 | 2005-08-03 | 北京生物制品研究所 | 脊髓灰质炎灭活疫苗及其制备方法 |
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2008
- 2008-08-28 SI SI200831190T patent/SI2192917T1/sl unknown
- 2008-08-28 CA CA2696090A patent/CA2696090C/en active Active
- 2008-08-28 HR HRP20140375AT patent/HRP20140375T1/hr unknown
- 2008-08-28 US US12/199,977 patent/US8497112B2/en active Active
- 2008-08-28 JP JP2010523124A patent/JP5535910B2/ja active Active
- 2008-08-28 AU AU2008293513A patent/AU2008293513B2/en active Active
- 2008-08-28 PL PL08828326T patent/PL2192917T3/pl unknown
- 2008-08-28 SG SG10201404101RA patent/SG10201404101RA/en unknown
- 2008-08-28 RU RU2010111747/10A patent/RU2496519C2/ru not_active IP Right Cessation
- 2008-08-28 CN CN200880105185.5A patent/CN101790381B/zh active Active
- 2008-08-28 EP EP08828326.2A patent/EP2192917B1/en active Active
- 2008-08-28 WO PCT/US2008/074559 patent/WO2009029695A1/en not_active Ceased
- 2008-08-28 KR KR1020107006633A patent/KR101760844B1/ko active Active
- 2008-08-28 BR BRPI0816130-5A2A patent/BRPI0816130A2/pt not_active IP Right Cessation
- 2008-08-28 ES ES08828326.2T patent/ES2459166T3/es active Active
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2010
- 2010-02-10 IL IL203869A patent/IL203869A/en active IP Right Grant
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2013
- 2013-06-26 US US13/928,094 patent/US20130287811A1/en not_active Abandoned
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1498261A (en) * | 1974-01-14 | 1978-01-18 | Sandoz Ltd | Influenza vaccines |
| EP0514199A2 (en) * | 1991-05-17 | 1992-11-19 | Retroscreen Limited | Vaccines and methods for their production |
| US6136321A (en) * | 1997-02-24 | 2000-10-24 | Baxter Aktiengesellschaft | Method of inactivating lipid-enveloped viruses |
| WO2000035481A2 (en) * | 1998-12-17 | 2000-06-22 | Connaught Laboratories Limited | Multivalent immunogenic composition containing rsv subunit composition and influenza virus preparation |
| US20040022808A1 (en) * | 2000-10-02 | 2004-02-05 | Colau Brigitte Desire Alberte | Vaccine |
| WO2002097072A2 (en) * | 2001-05-30 | 2002-12-05 | Saechsisches Serumwerk Dresden Branch Of Smithkline Beecham Pharma Gmbh & Co. Kg | Influenza vaccine composition |
| EP1724338A1 (en) * | 2005-05-19 | 2006-11-22 | Crucell Holland B.V. | Methods for the production of a whole-inactivated West Nile Virus vaccine |
Non-Patent Citations (1)
| Title |
|---|
| KISTNER, O., et al., "Cell Culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses," Vaccine, 4 June 2007, Vol. 25, No. 32, pages 6028-6036. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101790381A (zh) | 2010-07-28 |
| HK1143328A1 (en) | 2010-12-31 |
| RU2010111747A (ru) | 2011-10-10 |
| KR101760844B1 (ko) | 2017-07-24 |
| WO2009029695A1 (en) | 2009-03-05 |
| AU2008293513A1 (en) | 2009-03-05 |
| PL2192917T3 (pl) | 2014-06-30 |
| CA2696090A1 (en) | 2009-03-05 |
| JP2010537641A (ja) | 2010-12-09 |
| IL203869A (en) | 2016-05-31 |
| ES2459166T3 (es) | 2014-05-08 |
| KR20100075865A (ko) | 2010-07-05 |
| JP5535910B2 (ja) | 2014-07-02 |
| US20130287811A1 (en) | 2013-10-31 |
| EP2192917A1 (en) | 2010-06-09 |
| BRPI0816130A2 (pt) | 2015-02-24 |
| SI2192917T1 (sl) | 2014-05-30 |
| US8497112B2 (en) | 2013-07-30 |
| HRP20140375T1 (hr) | 2014-06-20 |
| EP2192917B1 (en) | 2014-01-29 |
| US20090060950A1 (en) | 2009-03-05 |
| RU2496519C2 (ru) | 2013-10-27 |
| CN101790381B (zh) | 2014-08-27 |
| SG10201404101RA (en) | 2014-09-26 |
| CA2696090C (en) | 2017-06-13 |
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