AU2008238250B2 - Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals - Google Patents

Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals Download PDF

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Publication number
AU2008238250B2
AU2008238250B2 AU2008238250A AU2008238250A AU2008238250B2 AU 2008238250 B2 AU2008238250 B2 AU 2008238250B2 AU 2008238250 A AU2008238250 A AU 2008238250A AU 2008238250 A AU2008238250 A AU 2008238250A AU 2008238250 B2 AU2008238250 B2 AU 2008238250B2
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butyl
group
denotes
case
methyl
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AU2008238250A
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AU2008238250A1 (en
Inventor
Gregor Bahrenberg
Thomas Christoph
Jean De Vry
Robert Frank
Jeewoo Lee
Derek John Saunders
Klaus Schiene
Bernd Sundermann
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Gruenenthal GmbH
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Gruenenthal GmbH
Chemie Gruenenthal GmbH
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Priority claimed from DE102007018149A external-priority patent/DE102007018149A1/de
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
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AU2008238250A 2007-04-16 2008-04-16 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals Ceased AU2008238250B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE102007018149A DE102007018149A1 (de) 2007-04-16 2007-04-16 Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018149.5 2007-04-16
EP2008002997 2008-04-15
US12/103,667 US8084484B2 (en) 2007-04-16 2008-04-15 Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions
US12/103,667 2008-04-15
EPPCT/EP2008/002997 2008-04-15
PCT/EP2008/003027 WO2008125342A2 (de) 2007-04-16 2008-04-16 Vanilloid-rezeptor-liganden und ihre verwendung zur herstellung von arzneimitteln

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AU2008238250A1 AU2008238250A1 (en) 2008-10-23
AU2008238250B2 true AU2008238250B2 (en) 2013-01-24

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AU2008238250A Ceased AU2008238250B2 (en) 2007-04-16 2008-04-16 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007018149A1 (de) 2007-04-16 2008-10-23 Grünenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
MX2011011797A (es) 2009-05-07 2011-11-29 Gruenenthal Gmbh Fenilureas y fenilamidas sustituidas como ligandos del receptor de vanilloides.
AR087302A1 (es) 2011-07-26 2014-03-12 Gruenenthal Gmbh Derivados aza heterociclicos sustituidos
KR20140049028A (ko) 2011-07-26 2014-04-24 그뤼넨탈 게엠베하 바닐로이드 수용체 리간드로서의 치환된 바이사이클릭 방향족 카복스아미드 및 우레아 유도체
HK1202116A1 (en) * 2011-11-09 2015-09-18 Grünenthal GmbH Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands
DK2822928T3 (en) * 2012-03-05 2019-03-11 Dr Reddys Laboratories Ltd SUBSTITUTED HETEROCYCLIC ACETAMIDS AS CAPE-OPIOID RECEPTOR (CHOR) AGONISTS
US10351535B2 (en) 2013-12-20 2019-07-16 Esteve Pharmaceuticals, S.A. Piperazine derivatives having multimodal activity against pain
CN107721919B (zh) * 2017-10-30 2020-12-08 中国药科大学 苯基喹啉类trpv1拮抗剂及其制备方法和应用
KR102334947B1 (ko) * 2020-04-22 2021-12-06 주식회사 제이맥켐 Trpv1 길항제로서 벤즈이미다졸론계 시남아마이드 유도체 및 이를 유효성분으로 함유하는 통증의 치료 또는 예방용 약학적 조성물
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070247A1 (en) * 2002-02-20 2003-08-28 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
WO2005016890A1 (en) * 2003-02-11 2005-02-24 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US20050113576A1 (en) * 2003-08-05 2005-05-26 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050009815A1 (en) * 2001-11-27 2005-01-13 Devita Robert J. 4-Aminoquinoline compounds
GB0206876D0 (en) * 2002-03-22 2002-05-01 Merck Sharp & Dohme Therapeutic agents
US20060211774A1 (en) * 2003-04-29 2006-09-21 Bennett Simon T Method of diagnosins a genetic susceptibility for bone damage
SE0301446D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
AU2004247559B2 (en) * 2003-06-12 2009-08-27 Astellas Pharma Inc. Benzamide derivative or salt thereof
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
EP1685112B1 (en) * 2003-11-08 2011-07-20 Bayer Schering Pharma Aktiengesellschaft Tetrahydro-quinolinylurea derivatives as vr1 antagonists
US20050165015A1 (en) * 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments
DE102005023943A1 (de) * 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
CA2856037C (en) * 2005-12-28 2017-03-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070247A1 (en) * 2002-02-20 2003-08-28 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
WO2005016890A1 (en) * 2003-02-11 2005-02-24 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US20050113576A1 (en) * 2003-08-05 2005-05-26 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

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ECSP099692A (es) 2009-11-30
CO6241154A2 (es) 2011-01-20
CN101679370A (zh) 2010-03-24
AU2008238250A1 (en) 2008-10-23
IL201505A0 (en) 2010-05-31
WO2008125342A3 (de) 2009-01-15
MX2009011149A (es) 2009-10-30
CA2683461A1 (en) 2008-10-23
WO2008125342A2 (de) 2008-10-23
RU2009142023A (ru) 2011-05-27
ZA200907099B (en) 2013-03-27
JP2010523727A (ja) 2010-07-15
KR20100016593A (ko) 2010-02-12
BRPI0810035A2 (pt) 2016-07-26
RU2498982C2 (ru) 2013-11-20

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