ECSP099692A - Ligandos de receptor de vainilloide novedosos y su uso de los mismos para la produccion de sustancias farmaceuticas - Google Patents

Ligandos de receptor de vainilloide novedosos y su uso de los mismos para la produccion de sustancias farmaceuticas

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Publication number
ECSP099692A
ECSP099692A EC2009009692A ECSP099692A ECSP099692A EC SP099692 A ECSP099692 A EC SP099692A EC 2009009692 A EC2009009692 A EC 2009009692A EC SP099692 A ECSP099692 A EC SP099692A EC SP099692 A ECSP099692 A EC SP099692A
Authority
EC
Ecuador
Prior art keywords
production
pharmaceutical substances
vinylloid
new
receiver links
Prior art date
Application number
EC2009009692A
Other languages
English (en)
Inventor
Jee Woo Lee
Vry Jean Marie Victor De
Thomas Christoph
Robert Frank
Gregor Bahrenberg
Klaus Schiene
Derek John Sauders
Bernd Saudermann
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007018149A external-priority patent/DE102007018149A1/de
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of ECSP099692A publication Critical patent/ECSP099692A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
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Abstract

La presente invención se relaciona con ligandos de receptor vainilloide novedosos, un método para la producción de los mismos, sustancias farmacéuticas que contienen dichos compuestos y el uso de tales compuestos para la producción de sustancias farmacéuticas.
EC2009009692A 2007-04-16 2009-10-16 Ligandos de receptor de vainilloide novedosos y su uso de los mismos para la produccion de sustancias farmaceuticas ECSP099692A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007018149A DE102007018149A1 (de) 2007-04-16 2007-04-16 Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US12/103,667 US8084484B2 (en) 2007-04-16 2008-04-15 Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions
EP2008002997 2008-04-15

Publications (1)

Publication Number Publication Date
ECSP099692A true ECSP099692A (es) 2009-11-30

Family

ID=41360190

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009692A ECSP099692A (es) 2007-04-16 2009-10-16 Ligandos de receptor de vainilloide novedosos y su uso de los mismos para la produccion de sustancias farmaceuticas

Country Status (14)

Country Link
JP (1) JP2010523727A (es)
KR (1) KR20100016593A (es)
CN (1) CN101679370A (es)
AU (1) AU2008238250B2 (es)
BR (1) BRPI0810035A2 (es)
CA (1) CA2683461A1 (es)
CO (1) CO6241154A2 (es)
EC (1) ECSP099692A (es)
IL (1) IL201505A0 (es)
MX (1) MX2009011149A (es)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007018149A1 (de) 2007-04-16 2008-10-23 Grünenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
WO2010127856A1 (en) * 2009-05-07 2010-11-11 Grünenthal GmbH Substituted phenyllureas and phenylamides as vanilloid receptor ligands
KR20140049027A (ko) 2011-07-26 2014-04-24 그뤼넨탈 게엠베하 치환된 헤테로사이클릭 아자 유도체
AU2012289254A1 (en) 2011-07-26 2014-03-13 Grünenthal GmbH Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands
AU2012334066A1 (en) * 2011-11-09 2014-05-22 Grunenthal Gmbh Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an N-containing group as vanilloid receptor ligands
KR101773331B1 (ko) * 2012-03-05 2017-08-31 닥터 레디스 레보러터리즈 리미티드 카파 오피오이드 수용체(κor) 작용제인 치환된 헤테로시클릭 아세트아미드
MX2016008130A (es) 2013-12-20 2016-10-13 Esteve Labor Dr Derivados de piperidina con actividad multimodal contra el dolor.
CN107721919B (zh) * 2017-10-30 2020-12-08 中国药科大学 苯基喹啉类trpv1拮抗剂及其制备方法和应用
KR102334947B1 (ko) * 2020-04-22 2021-12-06 주식회사 제이맥켐 Trpv1 길항제로서 벤즈이미다졸론계 시남아마이드 유도체 및 이를 유효성분으로 함유하는 통증의 치료 또는 예방용 약학적 조성물
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002352868A1 (en) * 2001-11-27 2003-06-10 Merck & Co., Inc. 4-aminoquinoline compounds
MXPA04008073A (es) * 2002-02-20 2004-11-26 Abbott Lab Compuestos azabiciclicos fusionados que inhiben el receptor de subtipo 1 (vr1) del receptor de vainilloide.
GB0206876D0 (en) * 2002-03-22 2002-05-01 Merck Sharp & Dohme Therapeutic agents
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US20060211774A1 (en) * 2003-04-29 2006-09-21 Bennett Simon T Method of diagnosins a genetic susceptibility for bone damage
SE0301446D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
MXPA05013434A (es) * 2003-06-12 2006-03-17 Astellas Pharma Inc Derivados de benzamida o sal del mismo.
US20050113576A1 (en) * 2003-08-05 2005-05-26 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
JP2007523888A (ja) * 2003-11-08 2007-08-23 バイエル・ヘルスケア・アクチェンゲゼルシャフト テトラヒドロ−キノリニル尿素誘導体
WO2005073193A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments
DE102005023943A1 (de) * 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
CN101395147B (zh) * 2005-12-28 2013-05-29 弗特克斯药品有限公司 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物

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ZA200907099B (en) 2013-03-27
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MX2009011149A (es) 2009-10-30
RU2009142023A (ru) 2011-05-27
RU2498982C2 (ru) 2013-11-20
AU2008238250B2 (en) 2013-01-24
CN101679370A (zh) 2010-03-24
BRPI0810035A2 (pt) 2016-07-26
IL201505A0 (en) 2010-05-31
CO6241154A2 (es) 2011-01-20
WO2008125342A2 (de) 2008-10-23
AU2008238250A1 (en) 2008-10-23
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