AU2005327308B2 - 18-membered macrocycles and analogs thereof - Google Patents

18-membered macrocycles and analogs thereof Download PDF

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Publication number
AU2005327308B2
AU2005327308B2 AU2005327308A AU2005327308A AU2005327308B2 AU 2005327308 B2 AU2005327308 B2 AU 2005327308B2 AU 2005327308 A AU2005327308 A AU 2005327308A AU 2005327308 A AU2005327308 A AU 2005327308A AU 2005327308 B2 AU2005327308 B2 AU 2005327308B2
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AU
Australia
Prior art keywords
tiacumicin
compound
formula
opt
compounds
Prior art date
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Active
Application number
AU2005327308A
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English (en)
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AU2005327308A1 (en
Inventor
Farah Babakhani
Yu-Hung Chiu
Chan-Kou Hwang
Franklin Okumu
Alex Romero
Pamela Sears
Youe-Kong Shue
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of AU2005327308A1 publication Critical patent/AU2005327308A1/en
Application granted granted Critical
Publication of AU2005327308B2 publication Critical patent/AU2005327308B2/en
Priority to AU2012200784A priority Critical patent/AU2012200784B2/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request for Assignment Assignors: OPTIMER PHARMACEUTICALS, INC.
Assigned to MERCK SHARP & DOHME LLC reassignment MERCK SHARP & DOHME LLC Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005327308A 2005-01-31 2005-01-31 18-membered macrocycles and analogs thereof Active AU2005327308B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012200784A AU2012200784B2 (en) 2005-01-31 2012-02-10 18-membered macrocycles and analogs thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/002887 WO2006085838A1 (en) 2005-01-31 2005-01-31 18-membered macrocycles and analogs thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012200784A Division AU2012200784B2 (en) 2005-01-31 2012-02-10 18-membered macrocycles and analogs thereof

Publications (2)

Publication Number Publication Date
AU2005327308A1 AU2005327308A1 (en) 2006-08-17
AU2005327308B2 true AU2005327308B2 (en) 2011-11-10

Family

ID=36793325

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005327308A Active AU2005327308B2 (en) 2005-01-31 2005-01-31 18-membered macrocycles and analogs thereof

Country Status (10)

Country Link
EP (1) EP1848273A4 (ja)
JP (1) JP5166040B2 (ja)
KR (1) KR101203118B1 (ja)
CN (2) CN102614207B (ja)
AU (1) AU2005327308B2 (ja)
BR (1) BRPI0519890A2 (ja)
CA (1) CA2596387C (ja)
MX (2) MX2007009196A (ja)
TW (1) TWI306097B (ja)
WO (1) WO2006085838A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
CN101340919B (zh) * 2005-10-21 2011-12-07 奥普蒂姆药物公司 治疗艰难梭菌相关的腹泻的方法
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
ZA200905337B (en) * 2007-01-22 2010-10-27 Optimer Pharmaceuticals Inc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
AU2012244278C1 (en) * 2007-01-22 2014-11-06 Merck Sharp & Dohme Llc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh) * 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
EP2670407A4 (en) * 2011-02-04 2014-07-23 Optimer Pharmaceuticals Inc TREATMENT OF BACTERIAL INFECTIONS
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
CN104768963A (zh) * 2012-05-10 2015-07-08 特瓦制药厂有限公司 非达霉素的固态形式及其制备方法
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
JP2017507994A (ja) 2014-03-18 2017-03-23 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ チアクマイシンｂの新たな多形及び新たな固体状態
CN103897003B (zh) * 2014-03-28 2016-07-06 华北制药集团新药研究开发有限责任公司 非达霉素晶型ii及其制备方法
CA2948400A1 (en) 2014-05-09 2015-11-12 Astellas Pharma Europe Ltd Treatment regimen tiacumicin compound
CA2990961A1 (en) 2015-07-03 2017-01-12 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound
CN105237599B (zh) * 2015-10-09 2018-10-02 华北制药集团新药研究开发有限责任公司 闰年霉素a4晶体及其制备方法
CN110183502A (zh) * 2019-05-28 2019-08-30 杭州华东医药集团新药研究院有限公司 一种非达霉素杂质及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5583115A (en) * 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
HUE043945T2 (hu) * 2004-05-14 2019-09-30 Merck Sharp & Dohme Betegségek kezelése antibiotikumok használatával összefüggésben

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CREDITO, K. L. et al: "Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 48, no. 11, November 2004 *
FINEGOLD, S.M. et al "In Vitro Activities of OPT-80 and Comparator Drugs against Intestinal Bacteria" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol. 48, No. 12, Dec. 2004, p. 4898-4902 *

Also Published As

Publication number Publication date
CA2596387A1 (en) 2006-08-17
AU2005327308A1 (en) 2006-08-17
JP2008528582A (ja) 2008-07-31
CN102614207A (zh) 2012-08-01
CN101128114B (zh) 2012-03-28
KR101203118B1 (ko) 2012-11-20
CN102614207B (zh) 2016-01-13
JP5166040B2 (ja) 2013-03-21
MX2007009196A (es) 2009-02-25
CN101128114A (zh) 2008-02-20
KR20070110504A (ko) 2007-11-19
CA2596387C (en) 2012-11-20
EP1848273A1 (en) 2007-10-31
EP1848273A4 (en) 2010-02-24
BRPI0519890A2 (pt) 2009-03-31
MX340742B (es) 2016-07-21
TW200626585A (en) 2006-08-01
WO2006085838A1 (en) 2006-08-17
TWI306097B (en) 2009-02-11

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: MERCK SHARP & DOHME CORP.

Free format text: FORMER OWNER WAS: OPTIMER PHARMACEUTICALS, INC.

HB Alteration of name in register

Owner name: MERCK SHARP & DOHME LLC

Free format text: FORMER NAME(S): MERCK SHARP & DOHME CORP.