KR101203118B1 - 18-원자 거대고리들 및 그 유사체들 - Google Patents

18-원자 거대고리들 및 그 유사체들 Download PDF

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Publication number
KR101203118B1
KR101203118B1 KR1020077019982A KR20077019982A KR101203118B1 KR 101203118 B1 KR101203118 B1 KR 101203118B1 KR 1020077019982 A KR1020077019982 A KR 1020077019982A KR 20077019982 A KR20077019982 A KR 20077019982A KR 101203118 B1 KR101203118 B1 KR 101203118B1
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South Korea
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tiacumicin
compound
opt
antibiotic
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KR1020077019982A
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Korean (ko)
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KR20070110504A (ko
Inventor
유-콩 슈
찬-고 황
유-훙 치우
알렉스 로메로
파라 바바카니
파멜라 시어즈
프랭클린 오쿠무
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옵티머 파마슈티칼즈, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077019982A 2005-01-31 2005-01-31 18-원자 거대고리들 및 그 유사체들 KR101203118B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/002887 WO2006085838A1 (en) 2005-01-31 2005-01-31 18-membered macrocycles and analogs thereof

Publications (2)

Publication Number Publication Date
KR20070110504A KR20070110504A (ko) 2007-11-19
KR101203118B1 true KR101203118B1 (ko) 2012-11-20

Family

ID=36793325

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Application Number Title Priority Date Filing Date
KR1020077019982A KR101203118B1 (ko) 2005-01-31 2005-01-31 18-원자 거대고리들 및 그 유사체들

Country Status (10)

Country Link
EP (1) EP1848273A4 (ja)
JP (1) JP5166040B2 (ja)
KR (1) KR101203118B1 (ja)
CN (2) CN102614207B (ja)
AU (1) AU2005327308B2 (ja)
BR (1) BRPI0519890A2 (ja)
CA (1) CA2596387C (ja)
MX (2) MX2007009196A (ja)
TW (1) TWI306097B (ja)
WO (1) WO2006085838A1 (ja)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
AU2006304868B2 (en) * 2005-10-21 2013-02-21 Merck Sharp & Dohme Corp. Method of treating clostridium difficile-associated diarrhea
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
US20080176927A1 (en) 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
AU2012244278C1 (en) * 2007-01-22 2014-11-06 Merck Sharp & Dohme Llc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
ZA200905337B (en) * 2007-01-22 2010-10-27 Optimer Pharmaceuticals Inc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh) * 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
CA2826662A1 (en) * 2011-02-04 2012-08-09 Optimer Pharmaceuticals, Inc. Treatment of bacterial infections
EP2855499A1 (en) * 2012-05-10 2015-04-08 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
KR20160134719A (ko) * 2014-03-18 2016-11-23 셀리아 파마슈티칼즈 에이피에스 신규한 다형체 및 신규한 고체 상태의 티아쿠미신 ｂ
CN103897003B (zh) * 2014-03-28 2016-07-06 华北制药集团新药研究开发有限责任公司 非达霉素晶型ii及其制备方法
US10137141B2 (en) 2014-05-09 2018-11-27 Astellas Pharma Europe Ltd. Treatment regimen tiacumicin compound
US10548912B2 (en) 2015-07-03 2020-02-04 Astellas Pharma Europe Ltd. Dosage regimen for a tiacumicin compound
CN105237599B (zh) * 2015-10-09 2018-10-02 华北制药集团新药研究开发有限责任公司 闰年霉素a4晶体及其制备方法
CN110183502A (zh) * 2019-05-28 2019-08-30 杭州华东医药集团新药研究院有限公司 一种非达霉素杂质及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5583115A (en) * 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
JP2005534332A (ja) * 2002-07-29 2005-11-17 オプティマー ファーマシューティカルズ、インコーポレイテッド チアクマイシン生産
PL2070530T3 (pl) * 2004-05-14 2016-06-30 Merck Sharp & Dohme Leczenie chorób związanych ze stosowaniem antybiotyków

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Antimicrobial Agents and Chemotherapy. 48(11), pp.4430-4434(2004.11.)*
The Journal of Antibiotics. 41(3), pp.308-315(1988.03.)*

Also Published As

Publication number Publication date
KR20070110504A (ko) 2007-11-19
WO2006085838A1 (en) 2006-08-17
CA2596387C (en) 2012-11-20
AU2005327308B2 (en) 2011-11-10
AU2005327308A1 (en) 2006-08-17
MX340742B (es) 2016-07-21
TWI306097B (en) 2009-02-11
CA2596387A1 (en) 2006-08-17
CN102614207B (zh) 2016-01-13
JP2008528582A (ja) 2008-07-31
CN101128114B (zh) 2012-03-28
JP5166040B2 (ja) 2013-03-21
TW200626585A (en) 2006-08-01
EP1848273A4 (en) 2010-02-24
MX2007009196A (es) 2009-02-25
BRPI0519890A2 (pt) 2009-03-31
CN102614207A (zh) 2012-08-01
EP1848273A1 (en) 2007-10-31
CN101128114A (zh) 2008-02-20

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