AU2005293752A1 - Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease - Google Patents
Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61814804P | 2004-10-13 | 2004-10-13 | |
| US60/618,148 | 2004-10-13 | ||
| US71861705P | 2005-09-20 | 2005-09-20 | |
| US60/718,617 | 2005-09-20 | ||
| PCT/EP2005/011018 WO2006040153A2 (en) | 2004-10-13 | 2005-10-13 | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005293752A1 true AU2005293752A1 (en) | 2006-04-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005293752A Abandoned AU2005293752A1 (en) | 2004-10-13 | 2005-10-13 | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080107601A1 (enExample) |
| EP (1) | EP1814917A2 (enExample) |
| JP (1) | JP5113523B2 (enExample) |
| KR (1) | KR20070084170A (enExample) |
| AU (1) | AU2005293752A1 (enExample) |
| BR (1) | BRPI0518151A2 (enExample) |
| CA (1) | CA2583017A1 (enExample) |
| IL (1) | IL182116A0 (enExample) |
| RU (1) | RU2007117752A (enExample) |
| WO (1) | WO2006040153A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006249090B2 (en) * | 2005-05-20 | 2012-08-23 | Ablynx N.V. | Single domain VHH antibodies against von Willebrand Factor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| AU2005269527B2 (en) | 2004-07-26 | 2011-12-01 | Pfenex Inc. | Process for improved protein expression by strain engineering |
| EP1785434A1 (en) * | 2005-11-11 | 2007-05-16 | Ludwig-Maximilians-Universität München | Targeting and tracing of antigens in living cells |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
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| RU2551782C2 (ru) | 2005-12-12 | 2015-05-27 | Ац Иммуне Са | Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами |
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| TWI551607B (zh) * | 2006-07-14 | 2016-10-01 | Ａｃ免疫公司 | 人類化抗體 |
| EP2069402A2 (en) * | 2006-09-08 | 2009-06-17 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| US20100034194A1 (en) * | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
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| EP2081960B1 (en) * | 2006-10-27 | 2018-06-27 | Ablynx N.V. | Intranasal delivery of polypeptides and proteins |
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| AU2007336242B2 (en) | 2006-12-19 | 2012-08-30 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| EP2514767A1 (en) | 2006-12-19 | 2012-10-24 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| EP2101801A1 (en) * | 2006-12-20 | 2009-09-23 | Ablynx N.V. | Oral delivery of polypeptides |
| EP2104682B1 (en) | 2007-01-11 | 2016-09-21 | Michael Bacher | Diagnosis and treatment of alzheimer's and other neurodementing diseases |
| AU2008206555B2 (en) * | 2007-01-18 | 2013-07-04 | Eli Lilly And Company | Pegylated Abeta Fab |
| US20110118185A9 (en) * | 2007-02-21 | 2011-05-19 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
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| EP1978035A1 (en) * | 2007-04-05 | 2008-10-08 | Hans-Knöll-Institut Leibniz-Institut für Naturstoff-Forschung | Anti-amyloid antibodies and their use in diagnosis and therapy of amyloid diseases |
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| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| EP2170389B1 (en) * | 2007-06-12 | 2014-10-29 | AC Immune S.A. | Humanized antibodies to amyloid beta |
| EP2009445A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
| EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| AU2008270274B2 (en) | 2007-07-03 | 2012-06-28 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
| EP2487190A3 (en) | 2007-07-13 | 2012-11-14 | Bac Ip B.V. | Single-domain antigen-binding proteins that bind mammalian IgG |
| CA2701790A1 (en) * | 2007-10-05 | 2009-04-16 | Ac Immune S.A. | Use of humanized anti-beta-amyloid antibody in ocular diseases |
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-
2005
- 2005-10-13 JP JP2007536090A patent/JP5113523B2/ja not_active Expired - Fee Related
- 2005-10-13 WO PCT/EP2005/011018 patent/WO2006040153A2/en not_active Ceased
- 2005-10-13 KR KR1020077010676A patent/KR20070084170A/ko not_active Withdrawn
- 2005-10-13 BR BRPI0518151-8A patent/BRPI0518151A2/pt not_active IP Right Cessation
- 2005-10-13 CA CA002583017A patent/CA2583017A1/en not_active Abandoned
- 2005-10-13 EP EP05797507A patent/EP1814917A2/en not_active Withdrawn
- 2005-10-13 RU RU2007117752/13A patent/RU2007117752A/ru not_active Application Discontinuation
- 2005-10-13 AU AU2005293752A patent/AU2005293752A1/en not_active Abandoned
- 2005-10-13 US US11/665,356 patent/US20080107601A1/en not_active Abandoned
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2007
- 2007-03-22 IL IL182116A patent/IL182116A0/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006249090B2 (en) * | 2005-05-20 | 2012-08-23 | Ablynx N.V. | Single domain VHH antibodies against von Willebrand Factor |
Also Published As
| Publication number | Publication date |
|---|---|
| IL182116A0 (en) | 2008-04-13 |
| JP5113523B2 (ja) | 2013-01-09 |
| JP2008515446A (ja) | 2008-05-15 |
| US20080107601A1 (en) | 2008-05-08 |
| EP1814917A2 (en) | 2007-08-08 |
| RU2007117752A (ru) | 2008-11-20 |
| WO2006040153A3 (en) | 2007-04-19 |
| KR20070084170A (ko) | 2007-08-24 |
| CA2583017A1 (en) | 2006-04-20 |
| WO2006040153A2 (en) | 2006-04-20 |
| BRPI0518151A2 (pt) | 2009-06-16 |
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