AU2003294281B2 - Antisense modulation of apolipoprotein B expression - Google Patents

Antisense modulation of apolipoprotein B expression Download PDF

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Publication number
AU2003294281B2
AU2003294281B2 AU2003294281A AU2003294281A AU2003294281B2 AU 2003294281 B2 AU2003294281 B2 AU 2003294281B2 AU 2003294281 A AU2003294281 A AU 2003294281A AU 2003294281 A AU2003294281 A AU 2003294281A AU 2003294281 B2 AU2003294281 B2 AU 2003294281B2
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Prior art keywords
antisense compound
compound
coding
apolipoprotein
antisense
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Ceased
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AU2003294281A
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AU2003294281A1 (en
Inventor
Rosanne Crooke
Kenneth W. Dobie
Susan M. Freier
Mark Graham
Kristina Lemonidis-Tarbet
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Kastle Therapeutics LLC
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Kastle Therapeutics LLC
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Priority claimed from PCT/US2003/015493 external-priority patent/WO2003097662A1/en
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Assigned to GENZYME CORPORATION reassignment GENZYME CORPORATION Request for Assignment Assignors: ISIS PHARMACEUTICALS, INC.
Assigned to KASTLE THERAPEUTICS, LLC reassignment KASTLE THERAPEUTICS, LLC Request for Assignment Assignors: GENZYME CORPORATION
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/13—Decoys
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003294281A 2002-11-13 2003-11-13 Antisense modulation of apolipoprotein B expression Ceased AU2003294281B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42623402P 2002-11-13 2002-11-13
US60/426,234 2002-11-13
AU2003237875 2003-05-15
PCT/US2003/015493 WO2003097662A1 (en) 2002-05-15 2003-05-15 Antisense modulation of apolipoprotein b expression
PCT/US2003/036411 WO2004044181A2 (en) 2002-11-13 2003-11-13 Antisense modulation of apolipoprotein b expression

Publications (2)

Publication Number Publication Date
AU2003294281A1 AU2003294281A1 (en) 2004-06-03
AU2003294281B2 true AU2003294281B2 (en) 2010-05-20

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Family Applications (1)

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AU2003294281A Ceased AU2003294281B2 (en) 2002-11-13 2003-11-13 Antisense modulation of apolipoprotein B expression

Country Status (5)

Country Link
EP (2) EP2336318B1 (https=)
JP (1) JP4986109B2 (https=)
AU (1) AU2003294281B2 (https=)
CA (1) CA2505801A1 (https=)
WO (1) WO2004044181A2 (https=)

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CA2505801A1 (en) 2004-05-27
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AU2003294281A1 (en) 2004-06-03
EP2336318B1 (en) 2013-04-24

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