AU2003283647B2 - Use of CPG oligonucleotides in the treatment of hepatitis C virus infection - Google Patents

Use of CPG oligonucleotides in the treatment of hepatitis C virus infection Download PDF

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Publication number
AU2003283647B2
AU2003283647B2 AU2003283647A AU2003283647A AU2003283647B2 AU 2003283647 B2 AU2003283647 B2 AU 2003283647B2 AU 2003283647 A AU2003283647 A AU 2003283647A AU 2003283647 A AU2003283647 A AU 2003283647A AU 2003283647 B2 AU2003283647 B2 AU 2003283647B2
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AU
Australia
Prior art keywords
cpg
nucleic acid
ifn
alpha
class
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003283647A
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English (en)
Other versions
AU2003283647A1 (en
Inventor
Navneet K. Ahluwalia
Heather L. Davis
Susan M. Efler
Jorg Vollmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coley Pharmaceutical Group Ltd
Coley Pharmaceutical GmbH
Original Assignee
Coley Pharmaceutical Group Ltd
Coley Pharmaceutical GmbH
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Filing date
Publication date
Application filed by Coley Pharmaceutical Group Ltd, Coley Pharmaceutical GmbH filed Critical Coley Pharmaceutical Group Ltd
Publication of AU2003283647A1 publication Critical patent/AU2003283647A1/en
Application granted granted Critical
Publication of AU2003283647B2 publication Critical patent/AU2003283647B2/en
Priority to AU2010203015A priority Critical patent/AU2010203015B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003283647A 2002-10-29 2003-10-29 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection Ceased AU2003283647B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2010203015A AU2010203015B2 (en) 2002-10-29 2010-07-15 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42198702P 2002-10-29 2002-10-29
US60/421,987 2002-10-29
PCT/IB2003/005520 WO2004039829A2 (en) 2002-10-29 2003-10-29 Use of cpg oligonucleotides in the treatment of hepatitis c virus infection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010203015A Division AU2010203015B2 (en) 2002-10-29 2010-07-15 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection

Publications (2)

Publication Number Publication Date
AU2003283647A1 AU2003283647A1 (en) 2004-05-25
AU2003283647B2 true AU2003283647B2 (en) 2010-04-15

Family

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Family Applications (2)

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AU2003283647A Ceased AU2003283647B2 (en) 2002-10-29 2003-10-29 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
AU2010203015A Ceased AU2010203015B2 (en) 2002-10-29 2010-07-15 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010203015A Ceased AU2010203015B2 (en) 2002-10-29 2010-07-15 Use of CPG oligonucleotides in the treatment of hepatitis C virus infection

Country Status (18)

Country Link
US (3) US7998492B2 (enExample)
EP (2) EP2241325B1 (enExample)
JP (1) JP2006515277A (enExample)
KR (1) KR20050089799A (enExample)
CN (2) CN101948835A (enExample)
AT (1) ATE544466T1 (enExample)
AU (2) AU2003283647B2 (enExample)
BR (1) BR0315810A (enExample)
CA (1) CA2503693A1 (enExample)
DK (1) DK2241325T3 (enExample)
EA (1) EA008777B1 (enExample)
ES (1) ES2381224T3 (enExample)
MX (1) MXPA05004588A (enExample)
NZ (1) NZ540098A (enExample)
PT (1) PT2241325E (enExample)
SI (1) SI2241325T1 (enExample)
WO (1) WO2004039829A2 (enExample)
ZA (1) ZA200503511B (enExample)

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