AU2003238752B2 - Mutant actinosynnema pretiosum strain with increased maytansinoid production - Google Patents

Mutant actinosynnema pretiosum strain with increased maytansinoid production Download PDF

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Publication number
AU2003238752B2
AU2003238752B2 AU2003238752A AU2003238752A AU2003238752B2 AU 2003238752 B2 AU2003238752 B2 AU 2003238752B2 AU 2003238752 A AU2003238752 A AU 2003238752A AU 2003238752 A AU2003238752 A AU 2003238752A AU 2003238752 B2 AU2003238752 B2 AU 2003238752B2
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Australia
Prior art keywords
strain
ansamitocin
enhanced
fold
actinosynnema pretiosum
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Expired
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AU2003238752A
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AU2003238752A1 (en
Inventor
Graham S. Byng
Johnson Chung
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Immunogen Inc
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Immunogen Inc
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Assigned to IMMUNOGEN, INC. reassignment IMMUNOGEN, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: IMMUNOGEN, INC.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2003238752A 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production Expired AU2003238752B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/057,561 US6790954B2 (en) 2002-01-29 2002-01-29 Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US10/057,561 2002-01-29
PCT/US2003/000026 WO2003064610A2 (en) 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production

Publications (2)

Publication Number Publication Date
AU2003238752A1 AU2003238752A1 (en) 2003-09-18
AU2003238752B2 true AU2003238752B2 (en) 2008-05-29

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ID=27658220

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003238752A Expired AU2003238752B2 (en) 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production

Country Status (14)

Country Link
US (2) US6790954B2 (enExample)
EP (1) EP1468077B1 (enExample)
JP (3) JP4485799B2 (enExample)
AT (1) ATE474043T1 (enExample)
AU (1) AU2003238752B2 (enExample)
CA (1) CA2474639C (enExample)
CY (1) CY1111210T1 (enExample)
DE (1) DE60333340D1 (enExample)
DK (1) DK1468077T3 (enExample)
ES (1) ES2348865T3 (enExample)
NZ (1) NZ532831A (enExample)
PT (1) PT1468077E (enExample)
SI (1) SI1468077T1 (enExample)
WO (1) WO2003064610A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
JP4414142B2 (ja) 2001-05-11 2010-02-10 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 特異的結合タンパク質およびその使用
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN104013956B (zh) 2007-01-25 2018-12-18 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
HUE035182T2 (hu) 2008-03-18 2018-05-02 Genentech Inc Anti-HER2 antitest-hatóanyag-konjugátum és pertuzumab kombinációi
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
TW201129380A (en) 2009-12-04 2011-09-01 Genentech Inc Methods of treating metastatic breast cancer with trastuzumab-MCC-DM1
AU2011215900A1 (en) 2010-02-10 2012-07-26 Immunogen, Inc. CD20 antibodies and uses thereof
CA2816426A1 (en) 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates
HRP20191019T1 (hr) 2015-07-07 2019-09-06 F. Hoffmann - La Roche Ag Kombinacijska terapija konjugatom protutijela i lijeka anti-her2 i inhibitorom bcl-2
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
WO2020212256A1 (en) 2019-04-18 2020-10-22 Indena S.P.A. Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
CN115322918B (zh) * 2021-05-11 2024-03-29 浙江珲达生物科技有限公司 一种高产安丝菌素p-3的菌株及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450234A (en) * 1979-09-19 1984-05-22 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHM and production thereof
WO2001077360A2 (en) * 2000-04-12 2001-10-18 Smithkline Beecham P.L.C. Methods for ansamitocin production

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS56102793A (en) * 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
JPS626673A (ja) * 1985-07-04 1987-01-13 Zenkoku Nogyo Kyodo Kumiai Rengokai パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法
US5250435A (en) 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
DE69225208T2 (de) 1991-12-17 1998-10-01 Gist Brocades Nv Phaffia rhodozyma-Stämme mit einer hohen intrazellulären Konzentration an Astaxanthin und einer niedrigen intrazellulären Konzentration an HDCO
JPH07274978A (ja) * 1994-04-13 1995-10-24 Bio Kosumosu:Kk 紅麹色素の製造方法
JP3376859B2 (ja) * 1996-11-27 2003-02-10 三菱化学株式会社 リビトールの製造方法
US6949356B1 (en) 1999-10-20 2005-09-27 Microbia, Inc. Methods for improving secondary metabolite production in fungi
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450234A (en) * 1979-09-19 1984-05-22 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHM and production thereof
WO2001077360A2 (en) * 2000-04-12 2001-10-18 Smithkline Beecham P.L.C. Methods for ansamitocin production

Also Published As

Publication number Publication date
US20050003513A1 (en) 2005-01-06
ATE474043T1 (de) 2010-07-15
SI1468077T1 (sl) 2010-11-30
EP1468077A4 (en) 2006-06-07
JP2010110328A (ja) 2010-05-20
WO2003064610A2 (en) 2003-08-07
JP2013230163A (ja) 2013-11-14
JP2005519594A (ja) 2005-07-07
EP1468077A2 (en) 2004-10-20
PT1468077E (pt) 2010-10-12
JP4485799B2 (ja) 2010-06-23
US7192750B2 (en) 2007-03-20
CA2474639A1 (en) 2003-08-07
DE60333340D1 (de) 2010-08-26
US6790954B2 (en) 2004-09-14
JP5840656B2 (ja) 2016-01-06
US20030157694A1 (en) 2003-08-21
WO2003064610A3 (en) 2004-01-22
CA2474639C (en) 2015-08-04
DK1468077T3 (da) 2010-10-25
EP1468077B1 (en) 2010-07-14
CY1111210T1 (el) 2015-06-11
NZ532831A (en) 2009-05-31
ES2348865T3 (es) 2010-12-16

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