JP4485799B2 - メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 - Google Patents

メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 Download PDF

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JP4485799B2
JP4485799B2 JP2003564206A JP2003564206A JP4485799B2 JP 4485799 B2 JP4485799 B2 JP 4485799B2 JP 2003564206 A JP2003564206 A JP 2003564206A JP 2003564206 A JP2003564206 A JP 2003564206A JP 4485799 B2 JP4485799 B2 JP 4485799B2
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ansamitocin
plethiosum
actinocinema
atcc
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JP2005519594A (ja
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チュン，ジョンソン
ビン，グラハム，エス．
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イムノージェン インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003564206A 2002-01-29 2003-01-15 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 Expired - Lifetime JP4485799B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/057,561 US6790954B2 (en) 2002-01-29 2002-01-29 Mutant Actinosynnema pretiosum strain with increased maytansinoid production
PCT/US2003/000026 WO2003064610A2 (en) 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production

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JP2009291891A Division JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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JP4485799B2 true JP4485799B2 (ja) 2010-06-23

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JP2003564206A Expired - Lifetime JP4485799B2 (ja) 2002-01-29 2003-01-15 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2009291891A Pending JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2013155694A Expired - Lifetime JP5840656B2 (ja) 2002-01-29 2013-07-26 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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JP2009291891A Pending JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2013155694A Expired - Lifetime JP5840656B2 (ja) 2002-01-29 2013-07-26 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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US (2) US6790954B2 (enExample)
EP (1) EP1468077B1 (enExample)
JP (3) JP4485799B2 (enExample)
AT (1) ATE474043T1 (enExample)
AU (1) AU2003238752B2 (enExample)
CA (1) CA2474639C (enExample)
CY (1) CY1111210T1 (enExample)
DE (1) DE60333340D1 (enExample)
DK (1) DK1468077T3 (enExample)
ES (1) ES2348865T3 (enExample)
NZ (1) NZ532831A (enExample)
PT (1) PT1468077E (enExample)
SI (1) SI1468077T1 (enExample)
WO (1) WO2003064610A2 (enExample)

Cited By (1)

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JP2013230163A (ja) * 2002-01-29 2013-11-14 Immunogen Inc メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
EP2163256B1 (en) 2001-05-11 2015-09-02 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
MX338185B (es) 2007-01-25 2016-04-05 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
EP2134854B1 (en) 2007-03-15 2015-04-15 Ludwig Institute for Cancer Research Ltd. Treatment method using egfr antibodies and src inhibitors and related formulations
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
WO2009023265A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
MY166445A (en) 2008-03-18 2018-06-27 Genentech Inc Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents,and methods of use
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
US20110165155A1 (en) 2009-12-04 2011-07-07 Genentech, Inc. Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
CN103313990B (zh) 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
LT3319995T (lt) 2015-07-07 2019-07-10 F. Hoffmann-La Roche Ag Sudėtinis gydymas anti-her-2 antikūno-vaisto konjugatu ir bcl-2 inhibitoriumi
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
US11420981B2 (en) 2019-04-18 2022-08-23 Indena S.P.A. Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
CN115322918B (zh) * 2021-05-11 2024-03-29 浙江珲达生物科技有限公司 一种高产安丝菌素p-3的菌株及其应用

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JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JPS56102793A (en) * 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
JPS626673A (ja) * 1985-07-04 1987-01-13 Zenkoku Nogyo Kyodo Kumiai Rengokai パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法
US5250435A (en) 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
ES2115637T3 (es) 1991-12-17 1998-07-01 Gist Brocades Nv Cepas de phaffia rhodozyma que tienen una alta concentracion intracelular de astaxantina y una baja concentracion intracelular de hdco.
JPH07274978A (ja) * 1994-04-13 1995-10-24 Bio Kosumosu:Kk 紅麹色素の製造方法
JP3376859B2 (ja) * 1996-11-27 2003-02-10 三菱化学株式会社 リビトールの製造方法
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US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013230163A (ja) * 2002-01-29 2013-11-14 Immunogen Inc メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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AU2003238752B2 (en) 2008-05-29
EP1468077A2 (en) 2004-10-20
NZ532831A (en) 2009-05-31
US20050003513A1 (en) 2005-01-06
DK1468077T3 (da) 2010-10-25
JP5840656B2 (ja) 2016-01-06
DE60333340D1 (de) 2010-08-26
ATE474043T1 (de) 2010-07-15
PT1468077E (pt) 2010-10-12
CA2474639C (en) 2015-08-04
CY1111210T1 (el) 2015-06-11
WO2003064610A2 (en) 2003-08-07
ES2348865T3 (es) 2010-12-16
JP2005519594A (ja) 2005-07-07
JP2013230163A (ja) 2013-11-14
JP2010110328A (ja) 2010-05-20
US6790954B2 (en) 2004-09-14
EP1468077A4 (en) 2006-06-07
EP1468077B1 (en) 2010-07-14
US20030157694A1 (en) 2003-08-21
WO2003064610A3 (en) 2004-01-22
US7192750B2 (en) 2007-03-20
CA2474639A1 (en) 2003-08-07
SI1468077T1 (sl) 2010-11-30

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