DE60333340D1 - Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion - Google Patents

Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion

Info

Publication number
DE60333340D1
DE60333340D1 DE60333340T DE60333340T DE60333340D1 DE 60333340 D1 DE60333340 D1 DE 60333340D1 DE 60333340 T DE60333340 T DE 60333340T DE 60333340 T DE60333340 T DE 60333340T DE 60333340 D1 DE60333340 D1 DE 60333340D1
Authority
DE
Germany
Prior art keywords
mutant
maytaninoid
production
increased
actinosynnema pretiosum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333340T
Other languages
English (en)
Inventor
Johnson Chung
Graham S Byng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunogen Inc
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Application granted granted Critical
Publication of DE60333340D1 publication Critical patent/DE60333340D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60333340T 2002-01-29 2003-01-15 Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion Expired - Lifetime DE60333340D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/057,561 US6790954B2 (en) 2002-01-29 2002-01-29 Mutant Actinosynnema pretiosum strain with increased maytansinoid production
PCT/US2003/000026 WO2003064610A2 (en) 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production

Publications (1)

Publication Number Publication Date
DE60333340D1 true DE60333340D1 (de) 2010-08-26

Family

ID=27658220

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333340T Expired - Lifetime DE60333340D1 (de) 2002-01-29 2003-01-15 Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion

Country Status (14)

Country Link
US (2) US6790954B2 (de)
EP (1) EP1468077B1 (de)
JP (3) JP4485799B2 (de)
AT (1) ATE474043T1 (de)
AU (1) AU2003238752B2 (de)
CA (1) CA2474639C (de)
CY (1) CY1111210T1 (de)
DE (1) DE60333340D1 (de)
DK (1) DK1468077T3 (de)
ES (1) ES2348865T3 (de)
NZ (1) NZ532831A (de)
PT (1) PT1468077E (de)
SI (1) SI1468077T1 (de)
WO (1) WO2003064610A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN104013956B (zh) 2007-01-25 2018-12-18 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
AU2008227123B2 (en) 2007-03-15 2014-03-27 Ludwig Institute For Cancer Research Ltd. Treatment method using EGFR antibodies and src inhibitors and related formulations
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
CA2696360C (en) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Monoclonal antibody targeting the egfr receptor and uses thereof
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
EP3692988A3 (de) 2008-03-18 2020-10-14 Genentech, Inc. Kombinationen eines anti-her2-antikörper-wirkstoff-konjugats und 5-fu,anti-vegf antikörper, carboplatin oder abt869 sowie verfahren zur verwendung
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
TW201129380A (en) 2009-12-04 2011-09-01 Genentech Inc Methods of treating metastatic breast cancer with trastuzumab-MCC-DM1
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
EP2640727B1 (de) 2010-11-17 2015-05-13 Genentech, Inc. Alaninylmaytansinol-antikörperkonjugate
SI3319995T1 (sl) 2015-07-07 2019-07-31 F. Hoffmann-La Roche Ag Kombinirana terapija s konjugatom protitelo anti-HER-2 in zdravilo ter zaviralcem bcl-2
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
US11420981B2 (en) 2019-04-18 2022-08-23 Indena S.P.A. Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
CN115322918B (zh) * 2021-05-11 2024-03-29 浙江珲达生物科技有限公司 一种高产安丝菌素p-3的菌株及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JPS56102793A (en) * 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
JPS626673A (ja) * 1985-07-04 1987-01-13 Zenkoku Nogyo Kyodo Kumiai Rengokai パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法
US5250435A (en) 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
US5648261A (en) 1991-12-17 1997-07-15 Gist-Brocades, N.V. Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-β, Ψ-caroten-4-one (HDCO)
JPH07274978A (ja) * 1994-04-13 1995-10-24 Bio Kosumosu:Kk 紅麹色素の製造方法
JP3376859B2 (ja) * 1996-11-27 2003-02-10 三菱化学株式会社 リビトールの製造方法
US6949356B1 (en) 1999-10-20 2005-09-27 Microbia, Inc. Methods for improving secondary metabolite production in fungi
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6790954B2 (en) * 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production

Also Published As

Publication number Publication date
EP1468077B1 (de) 2010-07-14
AU2003238752B2 (en) 2008-05-29
JP5840656B2 (ja) 2016-01-06
NZ532831A (en) 2009-05-31
US20030157694A1 (en) 2003-08-21
US7192750B2 (en) 2007-03-20
WO2003064610A2 (en) 2003-08-07
JP2005519594A (ja) 2005-07-07
CA2474639C (en) 2015-08-04
CA2474639A1 (en) 2003-08-07
JP2010110328A (ja) 2010-05-20
ATE474043T1 (de) 2010-07-15
WO2003064610A3 (en) 2004-01-22
EP1468077A2 (de) 2004-10-20
DK1468077T3 (da) 2010-10-25
US20050003513A1 (en) 2005-01-06
SI1468077T1 (sl) 2010-11-30
ES2348865T3 (es) 2010-12-16
EP1468077A4 (de) 2006-06-07
JP2013230163A (ja) 2013-11-14
PT1468077E (pt) 2010-10-12
JP4485799B2 (ja) 2010-06-23
US6790954B2 (en) 2004-09-14
CY1111210T1 (el) 2015-06-11

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