ATE474043T1 - Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion - Google Patents
Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktionInfo
- Publication number
- ATE474043T1 ATE474043T1 AT03734944T AT03734944T ATE474043T1 AT E474043 T1 ATE474043 T1 AT E474043T1 AT 03734944 T AT03734944 T AT 03734944T AT 03734944 T AT03734944 T AT 03734944T AT E474043 T1 ATE474043 T1 AT E474043T1
- Authority
- AT
- Austria
- Prior art keywords
- mutant
- increased
- maytansinoid
- actinosynnema pretiosum
- ansamitocins
- Prior art date
Links
- 241000143227 Actinosynnema pretiosum Species 0.000 title abstract 2
- OPQNCARIZFLNLF-UHFFFAOYSA-N ansamitocin P-3 Natural products CN1C(=O)CC(OC(=O)C(C)C)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 OPQNCARIZFLNLF-UHFFFAOYSA-N 0.000 abstract 1
- OPQNCARIZFLNLF-JBHFWYGFSA-N ansamitocin P3 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](OC(=O)C(C)C)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 OPQNCARIZFLNLF-JBHFWYGFSA-N 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/057,561 US6790954B2 (en) | 2002-01-29 | 2002-01-29 | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| PCT/US2003/000026 WO2003064610A2 (en) | 2002-01-29 | 2003-01-15 | Mutant actinosynnema pretiosum strain with increased maytansinoid production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474043T1 true ATE474043T1 (de) | 2010-07-15 |
Family
ID=27658220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03734944T ATE474043T1 (de) | 2002-01-29 | 2003-01-15 | Mutanter actinosynnema-pretiosum-stamm mit erhöhter maytansinoid-produktion |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6790954B2 (enExample) |
| EP (1) | EP1468077B1 (enExample) |
| JP (3) | JP4485799B2 (enExample) |
| AT (1) | ATE474043T1 (enExample) |
| AU (1) | AU2003238752B2 (enExample) |
| CA (1) | CA2474639C (enExample) |
| CY (1) | CY1111210T1 (enExample) |
| DE (1) | DE60333340D1 (enExample) |
| DK (1) | DK1468077T3 (enExample) |
| ES (1) | ES2348865T3 (enExample) |
| NZ (1) | NZ532831A (enExample) |
| PT (1) | PT1468077E (enExample) |
| SI (1) | SI1468077T1 (enExample) |
| WO (1) | WO2003064610A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| EP2163256B1 (en) | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| US7432088B2 (en) * | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| MX338185B (es) | 2007-01-25 | 2016-04-05 | Dana Farber Cancer Inst Inc | Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante. |
| EP2134854B1 (en) | 2007-03-15 | 2015-04-15 | Ludwig Institute for Cancer Research Ltd. | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
| US20090017140A1 (en) * | 2007-07-09 | 2009-01-15 | Peter Koepke | Maytenus abenfolia extract and methods of extracting and using such extract |
| US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
| WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
| US7879369B2 (en) * | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| MY166445A (en) | 2008-03-18 | 2018-06-27 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents,and methods of use |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US20110165155A1 (en) | 2009-12-04 | 2011-07-07 | Genentech, Inc. | Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1 |
| WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
| CN103313990B (zh) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | 丙氨酰美登醇抗体偶联物 |
| LT3319995T (lt) | 2015-07-07 | 2019-07-10 | F. Hoffmann-La Roche Ag | Sudėtinis gydymas anti-her-2 antikūno-vaisto konjugatu ir bcl-2 inhibitoriumi |
| CN108330113B (zh) * | 2018-03-08 | 2019-05-28 | 山东省医药生物技术研究中心（山东省病毒研究所） | 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用 |
| US11420981B2 (en) | 2019-04-18 | 2022-08-23 | Indena S.P.A. | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| CN115322918B (zh) * | 2021-05-11 | 2024-03-29 | 浙江珲达生物科技有限公司 | 一种高产安丝菌素p-3的菌株及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6016236B2 (ja) * | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | 抗生物質ｃ―１５００３ ｐ―３の製造法 |
| JPS5645483A (en) * | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS56102793A (en) * | 1979-12-28 | 1981-08-17 | Takeda Chem Ind Ltd | Preparation of antibiotic c-15003 p-3 |
| JPS626673A (ja) * | 1985-07-04 | 1987-01-13 | Zenkoku Nogyo Kyodo Kumiai Rengokai | パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法 |
| US5250435A (en) | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| ES2115637T3 (es) | 1991-12-17 | 1998-07-01 | Gist Brocades Nv | Cepas de phaffia rhodozyma que tienen una alta concentracion intracelular de astaxantina y una baja concentracion intracelular de hdco. |
| JPH07274978A (ja) * | 1994-04-13 | 1995-10-24 | Bio Kosumosu:Kk | 紅麹色素の製造方法 |
| JP3376859B2 (ja) * | 1996-11-27 | 2003-02-10 | 三菱化学株式会社 | リビトールの製造方法 |
| US6949356B1 (en) | 1999-10-20 | 2005-09-27 | Microbia, Inc. | Methods for improving secondary metabolite production in fungi |
| US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
-
2002
- 2002-01-29 US US10/057,561 patent/US6790954B2/en not_active Expired - Lifetime
-
2003
- 2003-01-15 EP EP03734944A patent/EP1468077B1/en not_active Expired - Lifetime
- 2003-01-15 JP JP2003564206A patent/JP4485799B2/ja not_active Expired - Lifetime
- 2003-01-15 DK DK03734944.6T patent/DK1468077T3/da active
- 2003-01-15 NZ NZ532831A patent/NZ532831A/en not_active IP Right Cessation
- 2003-01-15 DE DE60333340T patent/DE60333340D1/de not_active Expired - Lifetime
- 2003-01-15 AU AU2003238752A patent/AU2003238752B2/en not_active Expired
- 2003-01-15 SI SI200331875T patent/SI1468077T1/sl unknown
- 2003-01-15 PT PT03734944T patent/PT1468077E/pt unknown
- 2003-01-15 WO PCT/US2003/000026 patent/WO2003064610A2/en not_active Ceased
- 2003-01-15 AT AT03734944T patent/ATE474043T1/de active
- 2003-01-15 ES ES03734944T patent/ES2348865T3/es not_active Expired - Lifetime
- 2003-01-15 CA CA2474639A patent/CA2474639C/en not_active Expired - Lifetime
-
2004
- 2004-07-26 US US10/898,169 patent/US7192750B2/en not_active Expired - Lifetime
-
2009
- 2009-12-24 JP JP2009291891A patent/JP2010110328A/ja active Pending
-
2010
- 2010-09-30 CY CY20101100876T patent/CY1111210T1/el unknown
-
2013
- 2013-07-26 JP JP2013155694A patent/JP5840656B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003238752B2 (en) | 2008-05-29 |
| EP1468077A2 (en) | 2004-10-20 |
| NZ532831A (en) | 2009-05-31 |
| US20050003513A1 (en) | 2005-01-06 |
| DK1468077T3 (da) | 2010-10-25 |
| JP4485799B2 (ja) | 2010-06-23 |
| JP5840656B2 (ja) | 2016-01-06 |
| DE60333340D1 (de) | 2010-08-26 |
| PT1468077E (pt) | 2010-10-12 |
| CA2474639C (en) | 2015-08-04 |
| CY1111210T1 (el) | 2015-06-11 |
| WO2003064610A2 (en) | 2003-08-07 |
| ES2348865T3 (es) | 2010-12-16 |
| JP2005519594A (ja) | 2005-07-07 |
| JP2013230163A (ja) | 2013-11-14 |
| JP2010110328A (ja) | 2010-05-20 |
| US6790954B2 (en) | 2004-09-14 |
| EP1468077A4 (en) | 2006-06-07 |
| EP1468077B1 (en) | 2010-07-14 |
| US20030157694A1 (en) | 2003-08-21 |
| WO2003064610A3 (en) | 2004-01-22 |
| US7192750B2 (en) | 2007-03-20 |
| CA2474639A1 (en) | 2003-08-07 |
| SI1468077T1 (sl) | 2010-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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