AU2002338947B2 - Methods of increasing protein expression levels - Google Patents

Methods of increasing protein expression levels Download PDF

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Publication number
AU2002338947B2
AU2002338947B2 AU2002338947A AU2002338947A AU2002338947B2 AU 2002338947 B2 AU2002338947 B2 AU 2002338947B2 AU 2002338947 A AU2002338947 A AU 2002338947A AU 2002338947 A AU2002338947 A AU 2002338947A AU 2002338947 B2 AU2002338947 B2 AU 2002338947B2
Authority
AU
Australia
Prior art keywords
tnfred
proline
yeast
cells
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002338947A
Other languages
English (en)
Other versions
AU2002338947A1 (en
Inventor
William Brondyk
Xuliang Jiang
Rene Lynn Schweickhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Laboratoires Serono SA
Serono Laboratories UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono SA, Serono Laboratories UK Ltd filed Critical Laboratoires Serono SA
Publication of AU2002338947A1 publication Critical patent/AU2002338947A1/en
Application granted granted Critical
Publication of AU2002338947B2 publication Critical patent/AU2002338947B2/en
Assigned to LABORATOIRES SERONO SA reassignment LABORATOIRES SERONO SA Request for Assignment Assignors: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/144—Tumor necrosis factor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2002338947A 2001-11-30 2002-11-21 Methods of increasing protein expression levels Ceased AU2002338947B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34064801P 2001-11-30 2001-11-30
US60/340,648 2001-11-30
PCT/EP2002/013059 WO2003046160A2 (en) 2001-11-30 2002-11-21 Methods of increasing protein expression levels

Publications (2)

Publication Number Publication Date
AU2002338947A1 AU2002338947A1 (en) 2003-06-10
AU2002338947B2 true AU2002338947B2 (en) 2007-09-13

Family

ID=23334343

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002338947A Ceased AU2002338947B2 (en) 2001-11-30 2002-11-21 Methods of increasing protein expression levels

Country Status (12)

Country Link
US (2) US7258997B2 (enExample)
EP (1) EP1448772B1 (enExample)
JP (1) JP2005535281A (enExample)
AT (1) ATE367438T1 (enExample)
AU (1) AU2002338947B2 (enExample)
CA (1) CA2466298A1 (enExample)
DE (1) DE60221273D1 (enExample)
DK (1) DK1448772T3 (enExample)
ES (1) ES2290337T3 (enExample)
IL (1) IL162133A0 (enExample)
PT (1) PT1448772E (enExample)
WO (1) WO2003046160A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1448772B1 (en) * 2001-11-30 2007-07-18 Applied Research Systems ARS Holding N.V. Methods of increasing expression levels of human tnf receptor
AU2004309114A1 (en) * 2003-12-23 2005-07-14 Laboratoires Serono Sa Process for the production of tumor necrosis factor-binding proteins
US8722348B2 (en) 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
EP2705143B1 (en) 2011-05-02 2021-02-17 Wayne State University A protein-induced pluripotent cell technology uses thereof
JP6415582B2 (ja) 2013-10-25 2018-10-31 ウェイン ステート ユニバーシティー タンパク質誘導生体内細胞リプログラミングによる細胞転換に関する方法、システム、及び組成物
JP2022537052A (ja) * 2019-06-21 2022-08-23 カーナル バイオロジクス， インコーポレイテッド 操作された腫瘍選択的タンパク質発現
EP4100038A4 (en) * 2020-02-03 2024-02-28 Premas Biotech Private Limited RECOMBINANT EXPRESSION PLATFORM, CONSTRUCTS AND METHODS FOR EXPRESSING HARD-TO-EXPRESS PROTEINS (DTE-PS)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766917A (en) * 1993-10-12 1998-06-16 Yeda Research And Development Co. Ltd. Method for identifying and producing a protease capable of cleaving the TNF receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0393438T3 (da) * 1989-04-21 2005-05-30 Amgen Inc TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
AU3073692A (en) * 1991-11-25 1993-06-28 Richardson-Vicks Inc. Compositions for regulating skin wrinkles and/or skin atrophy
AU2001286171B2 (en) * 2001-05-25 2008-01-10 Serono Genetics Institute S.A. Human CDNAs and proteins and uses thereof
EP1448772B1 (en) * 2001-11-30 2007-07-18 Applied Research Systems ARS Holding N.V. Methods of increasing expression levels of human tnf receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766917A (en) * 1993-10-12 1998-06-16 Yeda Research And Development Co. Ltd. Method for identifying and producing a protease capable of cleaving the TNF receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Aksentijevich I et al., The Am J of Human Genetics, 2001, 69(9), 301-314 *

Also Published As

Publication number Publication date
US7258997B2 (en) 2007-08-21
ES2290337T3 (es) 2008-02-16
EP1448772A2 (en) 2004-08-25
CA2466298A1 (en) 2003-06-05
PT1448772E (pt) 2007-10-02
WO2003046160A2 (en) 2003-06-05
ATE367438T1 (de) 2007-08-15
JP2005535281A (ja) 2005-11-24
US20080014635A1 (en) 2008-01-17
IL162133A0 (en) 2005-11-20
AU2002338947A1 (en) 2003-06-10
EP1448772B1 (en) 2007-07-18
WO2003046160A3 (en) 2003-07-31
US20050074840A1 (en) 2005-04-07
DK1448772T3 (da) 2007-11-19
DE60221273D1 (de) 2007-08-30

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: LABORATOIRES SERONO SA

Free format text: FORMER APPLICANT(S): APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired