PT1448772E - Método para aumentar os níveis de expressão do receptor de tnf humano - Google Patents

Método para aumentar os níveis de expressão do receptor de tnf humano Download PDF

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Publication number
PT1448772E
PT1448772E PT02777356T PT02777356T PT1448772E PT 1448772 E PT1448772 E PT 1448772E PT 02777356 T PT02777356 T PT 02777356T PT 02777356 T PT02777356 T PT 02777356T PT 1448772 E PT1448772 E PT 1448772E
Authority
PT
Portugal
Prior art keywords
tnfred
proline
mutant
amino acid
yeast
Prior art date
Application number
PT02777356T
Other languages
English (en)
Portuguese (pt)
Inventor
William Brondyk
Xuliang Jiang
Rene Lynn Schweickhardt
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of PT1448772E publication Critical patent/PT1448772E/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/144Tumor necrosis factor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
PT02777356T 2001-11-30 2002-11-21 Método para aumentar os níveis de expressão do receptor de tnf humano PT1448772E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34064801P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
PT1448772E true PT1448772E (pt) 2007-10-02

Family

ID=23334343

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02777356T PT1448772E (pt) 2001-11-30 2002-11-21 Método para aumentar os níveis de expressão do receptor de tnf humano

Country Status (12)

Country Link
US (2) US7258997B2 (enExample)
EP (1) EP1448772B1 (enExample)
JP (1) JP2005535281A (enExample)
AT (1) ATE367438T1 (enExample)
AU (1) AU2002338947B2 (enExample)
CA (1) CA2466298A1 (enExample)
DE (1) DE60221273D1 (enExample)
DK (1) DK1448772T3 (enExample)
ES (1) ES2290337T3 (enExample)
IL (1) IL162133A0 (enExample)
PT (1) PT1448772E (enExample)
WO (1) WO2003046160A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003046160A2 (en) * 2001-11-30 2003-06-05 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels
AU2004309114A1 (en) * 2003-12-23 2005-07-14 Laboratoires Serono Sa Process for the production of tumor necrosis factor-binding proteins
US8722348B2 (en) 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
WO2012151234A2 (en) 2011-05-02 2012-11-08 Wayne State University A protein-induced pluripotent cell technology uses thereof
PT3060237T (pt) 2013-10-25 2021-11-09 Univ Wayne State Proteína de reprogramação modificada para utilização no tratamento de um cancro
EP3987028A4 (en) * 2019-06-21 2023-07-19 Kernal Biologics, Inc. MODIFIED ONCOSELECTIVE PROTEIN EXPRESSION
JP2023522534A (ja) * 2020-02-03 2023-05-31 プレマス バイオテック プライベート リミテッド 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59010941D1 (de) * 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
AU3073692A (en) * 1991-11-25 1993-06-28 Richardson-Vicks Inc. Compositions for regulating skin wrinkles and/or skin atrophy
IL107268A0 (en) * 1993-10-12 1994-01-25 Yeda Res & Dev Molecules influencing the shedding of the tnf receptor, their preparation and their use
JP2005508141A (ja) * 2001-05-25 2005-03-31 セローノ ジェネティクス インスティテュート ソシエテ アニニム ヒトcDNAおよびタンパク質、ならびにそれらの使用
WO2003046160A2 (en) * 2001-11-30 2003-06-05 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels

Also Published As

Publication number Publication date
US20050074840A1 (en) 2005-04-07
EP1448772A2 (en) 2004-08-25
DK1448772T3 (da) 2007-11-19
WO2003046160A2 (en) 2003-06-05
US7258997B2 (en) 2007-08-21
JP2005535281A (ja) 2005-11-24
DE60221273D1 (de) 2007-08-30
ATE367438T1 (de) 2007-08-15
CA2466298A1 (en) 2003-06-05
EP1448772B1 (en) 2007-07-18
WO2003046160A3 (en) 2003-07-31
AU2002338947B2 (en) 2007-09-13
US20080014635A1 (en) 2008-01-17
ES2290337T3 (es) 2008-02-16
AU2002338947A1 (en) 2003-06-10
IL162133A0 (en) 2005-11-20

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