CA2466298A1 - Methods of increasing protein expression levels - Google Patents

Methods of increasing protein expression levels Download PDF

Info

Publication number
CA2466298A1
CA2466298A1 CA002466298A CA2466298A CA2466298A1 CA 2466298 A1 CA2466298 A1 CA 2466298A1 CA 002466298 A CA002466298 A CA 002466298A CA 2466298 A CA2466298 A CA 2466298A CA 2466298 A1 CA2466298 A1 CA 2466298A1
Authority
CA
Canada
Prior art keywords
tnfred
amino acid
proline
substituted
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002466298A
Other languages
English (en)
French (fr)
Inventor
William Brondyk
Xuliang Jiang
Rene Lynn Schweickhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2466298A1 publication Critical patent/CA2466298A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/144—Tumor necrosis factor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
CA002466298A 2001-11-30 2002-11-21 Methods of increasing protein expression levels Abandoned CA2466298A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34064801P 2001-11-30 2001-11-30
US60/340,648 2001-11-30
PCT/EP2002/013059 WO2003046160A2 (en) 2001-11-30 2002-11-21 Methods of increasing protein expression levels

Publications (1)

Publication Number Publication Date
CA2466298A1 true CA2466298A1 (en) 2003-06-05

Family

ID=23334343

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002466298A Abandoned CA2466298A1 (en) 2001-11-30 2002-11-21 Methods of increasing protein expression levels

Country Status (12)

Country Link
US (2) US7258997B2 (enExample)
EP (1) EP1448772B1 (enExample)
JP (1) JP2005535281A (enExample)
AT (1) ATE367438T1 (enExample)
AU (1) AU2002338947B2 (enExample)
CA (1) CA2466298A1 (enExample)
DE (1) DE60221273D1 (enExample)
DK (1) DK1448772T3 (enExample)
ES (1) ES2290337T3 (enExample)
IL (1) IL162133A0 (enExample)
PT (1) PT1448772E (enExample)
WO (1) WO2003046160A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7258997B2 (en) * 2001-11-30 2007-08-21 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels
WO2005063813A2 (en) * 2003-12-23 2005-07-14 Applied Research Systems Ars Holding N.V. Process for the production of tumor necrosis factor-binding proteins
US8722348B2 (en) * 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
PT2705143T (pt) 2011-05-02 2021-04-07 Univ Wayne State Tecnologia de células pluripotentes induzidas por proteínas e utilizações da mesma
KR102113829B1 (ko) 2013-10-25 2020-05-25 웨인 스테이트 유니버시티 단백질-유도 생체내 세포 재프로그래밍을 통한 세포 전환 방법, 시스템 및 조성물
CA3144637A1 (en) * 2019-06-21 2020-12-24 Kernal Biologics, Inc. Engineered oncoselective protein expression
JP2023522534A (ja) * 2020-02-03 2023-05-31 プレマス バイオテック プライベート リミテッド 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59010941D1 (de) 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
EP0614353A1 (en) * 1991-11-25 1994-09-14 Richardson-Vicks, Inc. Compositions for regulating skin wrinkles and/or skin atrophy
IL107268A0 (en) 1993-10-12 1994-01-25 Yeda Res & Dev Molecules influencing the shedding of the tnf receptor, their preparation and their use
WO2002094864A2 (en) * 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
US7258997B2 (en) * 2001-11-30 2007-08-21 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels

Also Published As

Publication number Publication date
US7258997B2 (en) 2007-08-21
IL162133A0 (en) 2005-11-20
ES2290337T3 (es) 2008-02-16
AU2002338947B2 (en) 2007-09-13
US20080014635A1 (en) 2008-01-17
DE60221273D1 (de) 2007-08-30
EP1448772B1 (en) 2007-07-18
PT1448772E (pt) 2007-10-02
AU2002338947A1 (en) 2003-06-10
US20050074840A1 (en) 2005-04-07
ATE367438T1 (de) 2007-08-15
EP1448772A2 (en) 2004-08-25
WO2003046160A2 (en) 2003-06-05
DK1448772T3 (da) 2007-11-19
WO2003046160A3 (en) 2003-07-31
JP2005535281A (ja) 2005-11-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued