JP2005535281A - タンパク質の発現レベルを増大させるための方法 - Google Patents

タンパク質の発現レベルを増大させるための方法 Download PDF

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JP2005535281A
JP2005535281A JP2003547592A JP2003547592A JP2005535281A JP 2005535281 A JP2005535281 A JP 2005535281A JP 2003547592 A JP2003547592 A JP 2003547592A JP 2003547592 A JP2003547592 A JP 2003547592A JP 2005535281 A JP2005535281 A JP 2005535281A
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tnfred
amino acid
proline
protein
substituted
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Japanese (ja)
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JP2005535281A5 (enExample
Inventor
ブロンダイク,ウィリアム
ジャン,シューリャン
リン シュバイクハート,レネ
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アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ
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Publication of JP2005535281A publication Critical patent/JP2005535281A/ja
Publication of JP2005535281A5 publication Critical patent/JP2005535281A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/144—Tumor necrosis factor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP2003547592A 2001-11-30 2002-11-21 タンパク質の発現レベルを増大させるための方法 Pending JP2005535281A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34064801P 2001-11-30 2001-11-30
PCT/EP2002/013059 WO2003046160A2 (en) 2001-11-30 2002-11-21 Methods of increasing protein expression levels

Publications (2)

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JP2005535281A true JP2005535281A (ja) 2005-11-24
JP2005535281A5 JP2005535281A5 (enExample) 2006-01-12

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JP2003547592A Pending JP2005535281A (ja) 2001-11-30 2002-11-21 タンパク質の発現レベルを増大させるための方法

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US (2) US7258997B2 (enExample)
EP (1) EP1448772B1 (enExample)
JP (1) JP2005535281A (enExample)
AT (1) ATE367438T1 (enExample)
AU (1) AU2002338947B2 (enExample)
CA (1) CA2466298A1 (enExample)
DE (1) DE60221273D1 (enExample)
DK (1) DK1448772T3 (enExample)
ES (1) ES2290337T3 (enExample)
IL (1) IL162133A0 (enExample)
PT (1) PT1448772E (enExample)
WO (1) WO2003046160A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023522534A (ja) * 2020-02-03 2023-05-31 プレマス バイオテック プライベート リミテッド 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7258997B2 (en) * 2001-11-30 2007-08-21 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels
WO2005063813A2 (en) * 2003-12-23 2005-07-14 Applied Research Systems Ars Holding N.V. Process for the production of tumor necrosis factor-binding proteins
US8722348B2 (en) * 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
PT2705143T (pt) 2011-05-02 2021-04-07 Univ Wayne State Tecnologia de células pluripotentes induzidas por proteínas e utilizações da mesma
KR102113829B1 (ko) 2013-10-25 2020-05-25 웨인 스테이트 유니버시티 단백질-유도 생체내 세포 재프로그래밍을 통한 세포 전환 방법, 시스템 및 조성물
CA3144637A1 (en) * 2019-06-21 2020-12-24 Kernal Biologics, Inc. Engineered oncoselective protein expression

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59010941D1 (de) 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
EP0614353A1 (en) * 1991-11-25 1994-09-14 Richardson-Vicks, Inc. Compositions for regulating skin wrinkles and/or skin atrophy
IL107268A0 (en) 1993-10-12 1994-01-25 Yeda Res & Dev Molecules influencing the shedding of the tnf receptor, their preparation and their use
WO2002094864A2 (en) * 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
US7258997B2 (en) * 2001-11-30 2007-08-21 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023522534A (ja) * 2020-02-03 2023-05-31 プレマス バイオテック プライベート リミテッド 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法
JP2025186250A (ja) * 2020-02-03 2025-12-23 プレマス バイオテック プライベート リミテッド 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法

Also Published As

Publication number Publication date
CA2466298A1 (en) 2003-06-05
US7258997B2 (en) 2007-08-21
IL162133A0 (en) 2005-11-20
ES2290337T3 (es) 2008-02-16
AU2002338947B2 (en) 2007-09-13
US20080014635A1 (en) 2008-01-17
DE60221273D1 (de) 2007-08-30
EP1448772B1 (en) 2007-07-18
PT1448772E (pt) 2007-10-02
AU2002338947A1 (en) 2003-06-10
US20050074840A1 (en) 2005-04-07
ATE367438T1 (de) 2007-08-15
EP1448772A2 (en) 2004-08-25
WO2003046160A2 (en) 2003-06-05
DK1448772T3 (da) 2007-11-19
WO2003046160A3 (en) 2003-07-31

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