IL162133A0 - Method of increasing protein expression, proteins and polynucleotides - Google Patents
Method of increasing protein expression, proteins and polynucleotidesInfo
- Publication number
- IL162133A0 IL162133A0 IL16213302A IL16213302A IL162133A0 IL 162133 A0 IL162133 A0 IL 162133A0 IL 16213302 A IL16213302 A IL 16213302A IL 16213302 A IL16213302 A IL 16213302A IL 162133 A0 IL162133 A0 IL 162133A0
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- polynucleotides
- proline
- protein expression
- proteins
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 7
- 235000001014 amino acid Nutrition 0.000 abstract 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 4
- 108020004705 Codon Proteins 0.000 abstract 3
- 238000006467 substitution reaction Methods 0.000 abstract 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/144—Tumor necrosis factor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34064801P | 2001-11-30 | 2001-11-30 | |
| PCT/EP2002/013059 WO2003046160A2 (en) | 2001-11-30 | 2002-11-21 | Methods of increasing protein expression levels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL162133A0 true IL162133A0 (en) | 2005-11-20 |
Family
ID=23334343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16213302A IL162133A0 (en) | 2001-11-30 | 2002-11-21 | Method of increasing protein expression, proteins and polynucleotides |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7258997B2 (enExample) |
| EP (1) | EP1448772B1 (enExample) |
| JP (1) | JP2005535281A (enExample) |
| AT (1) | ATE367438T1 (enExample) |
| AU (1) | AU2002338947B2 (enExample) |
| CA (1) | CA2466298A1 (enExample) |
| DE (1) | DE60221273D1 (enExample) |
| DK (1) | DK1448772T3 (enExample) |
| ES (1) | ES2290337T3 (enExample) |
| IL (1) | IL162133A0 (enExample) |
| PT (1) | PT1448772E (enExample) |
| WO (1) | WO2003046160A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7258997B2 (en) * | 2001-11-30 | 2007-08-21 | Applied Research Systems Ars Holding N.V. | Methods of increasing protein expression levels |
| WO2005063813A2 (en) * | 2003-12-23 | 2005-07-14 | Applied Research Systems Ars Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| US8722348B2 (en) * | 2008-05-28 | 2014-05-13 | Wayne State University | Method and composition for a protein transduction technology and its applications |
| PT2705143T (pt) | 2011-05-02 | 2021-04-07 | Univ Wayne State | Tecnologia de células pluripotentes induzidas por proteínas e utilizações da mesma |
| KR102113829B1 (ko) | 2013-10-25 | 2020-05-25 | 웨인 스테이트 유니버시티 | 단백질-유도 생체내 세포 재프로그래밍을 통한 세포 전환 방법, 시스템 및 조성물 |
| CA3144637A1 (en) * | 2019-06-21 | 2020-12-24 | Kernal Biologics, Inc. | Engineered oncoselective protein expression |
| JP2023522534A (ja) * | 2020-02-03 | 2023-05-31 | プレマス バイオテック プライベート リミテッド | 発現が困難なタンパク質を発現させるための、組換え発現プラットフォーム、構築物、および方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59010941D1 (de) | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
| EP0614353A1 (en) * | 1991-11-25 | 1994-09-14 | Richardson-Vicks, Inc. | Compositions for regulating skin wrinkles and/or skin atrophy |
| IL107268A0 (en) | 1993-10-12 | 1994-01-25 | Yeda Res & Dev | Molecules influencing the shedding of the tnf receptor, their preparation and their use |
| WO2002094864A2 (en) * | 2001-05-25 | 2002-11-28 | Genset S.A. | Human cdnas and proteins and uses thereof |
| US7258997B2 (en) * | 2001-11-30 | 2007-08-21 | Applied Research Systems Ars Holding N.V. | Methods of increasing protein expression levels |
-
2002
- 2002-11-21 US US10/496,218 patent/US7258997B2/en not_active Expired - Fee Related
- 2002-11-21 IL IL16213302A patent/IL162133A0/xx unknown
- 2002-11-21 WO PCT/EP2002/013059 patent/WO2003046160A2/en not_active Ceased
- 2002-11-21 DE DE60221273T patent/DE60221273D1/de not_active Expired - Lifetime
- 2002-11-21 CA CA002466298A patent/CA2466298A1/en not_active Abandoned
- 2002-11-21 DK DK02777356T patent/DK1448772T3/da active
- 2002-11-21 JP JP2003547592A patent/JP2005535281A/ja active Pending
- 2002-11-21 PT PT02777356T patent/PT1448772E/pt unknown
- 2002-11-21 ES ES02777356T patent/ES2290337T3/es not_active Expired - Lifetime
- 2002-11-21 AU AU2002338947A patent/AU2002338947B2/en not_active Ceased
- 2002-11-21 AT AT02777356T patent/ATE367438T1/de not_active IP Right Cessation
- 2002-11-21 EP EP02777356A patent/EP1448772B1/en not_active Expired - Lifetime
-
2007
- 2007-07-16 US US11/778,593 patent/US20080014635A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2466298A1 (en) | 2003-06-05 |
| US7258997B2 (en) | 2007-08-21 |
| ES2290337T3 (es) | 2008-02-16 |
| AU2002338947B2 (en) | 2007-09-13 |
| US20080014635A1 (en) | 2008-01-17 |
| DE60221273D1 (de) | 2007-08-30 |
| EP1448772B1 (en) | 2007-07-18 |
| PT1448772E (pt) | 2007-10-02 |
| AU2002338947A1 (en) | 2003-06-10 |
| US20050074840A1 (en) | 2005-04-07 |
| ATE367438T1 (de) | 2007-08-15 |
| EP1448772A2 (en) | 2004-08-25 |
| WO2003046160A2 (en) | 2003-06-05 |
| DK1448772T3 (da) | 2007-11-19 |
| WO2003046160A3 (en) | 2003-07-31 |
| JP2005535281A (ja) | 2005-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2002002627A3 (en) | Interferon-like protein zcyto21 | |
| DE60323210D1 (en) | Eukaryontische signalsequenzen für polypeptid-expr | |
| EA199900939A1 (ru) | Остеопротегерин-связывающие белки и рецепторы | |
| PL366826A1 (en) | Reducing the immunogenicity of fusion proteins | |
| IL184112A0 (en) | A method for producing polypeptides or proteins in a disulfide-bridged two-chain form | |
| ATE417595T1 (de) | Keratin-bindende polypeptide | |
| WO2002103024A3 (en) | Stabilized proteins with engineered disulfide bonds | |
| WO2002060951A3 (en) | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii | |
| UA97628C2 (ru) | Способ получения fc-фрагмента иммуноглобулина, свободного от начального метионинового остатка, в массовом масштабе | |
| PT1346034E (pt) | Polipéptido da protease de clivagem do factor de von willebrand (vwf), ácido nucleico que codifica o polipéptido e utilização do polipéptido | |
| EP0965637A4 (en) | Fas ANTIGEN DERIVATIVES | |
| WO2000071714A3 (en) | Methods of reducing factor viii clearance and compositions therefor | |
| DE60335726D1 (de) | Chromoprotein und fluoroproteine | |
| SG166117A1 (en) | Methods and compositions for treatment of interferon-resistant tumors | |
| FR2766191B1 (fr) | Peptides anti-microbiens de crustaces | |
| PE20020857A1 (es) | Proteinas de fusion cuya parte del n-terminal es un derivado de hirudina para la produccion de proteinas recombinantes a traves de la secresion por levaduras | |
| DK1098972T3 (da) | Protein med lighed med neuroendokrinspecifikt protein samt cDNA kodende derfor | |
| NZ508816A (en) | Bactericidal/permeability-increasing protein (BPI) deletion analogs | |
| DE60118359D1 (de) | Humanische pellino-polypeptide | |
| DE60221273D1 (de) | Verfahren zur steigerung der expression von menschlichen tnf-rezeptor | |
| NO971508L (no) | Analoger av sur fibroblastvekstfaktor med forökt stabilitet og biologisk aktivitet | |
| WO2000058465A3 (en) | Flint polypeptide analogs | |
| EA200400392A1 (ru) | Связывающий каспазу-8 белок, его получение и применение | |
| AU2676399A (en) | Novel cystine knot protein and materials and methods for making it | |
| WO2000000506A3 (en) | Human proteins having hydrophobic domains and dnas encoding these proteins |