AU2002248910A1 - Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines - Google Patents
Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidinesInfo
- Publication number
- AU2002248910A1 AU2002248910A1 AU2002248910A AU4891002A AU2002248910A1 AU 2002248910 A1 AU2002248910 A1 AU 2002248910A1 AU 2002248910 A AU2002248910 A AU 2002248910A AU 4891002 A AU4891002 A AU 4891002A AU 2002248910 A1 AU2002248910 A1 AU 2002248910A1
- Authority
- AU
- Australia
- Prior art keywords
- aryl
- alkyl
- halogen
- cycloalkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24953200P | 2000-11-17 | 2000-11-17 | |
US60/249532 | 2000-11-17 | ||
PCT/US2001/045652 WO2002040021A2 (fr) | 2000-11-17 | 2001-11-19 | Procedes d'inhibition de la transmission du vih au moyen de 6-benzyl-4-oxopyrimidines substituees a application topique |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002248910A1 true AU2002248910A1 (en) | 2002-05-27 |
Family
ID=22943884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002248910A Abandoned AU2002248910A1 (en) | 2000-11-17 | 2001-11-19 | Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines |
Country Status (6)
Country | Link |
---|---|
US (4) | US6545007B2 (fr) |
EP (1) | EP1343502A2 (fr) |
AU (1) | AU2002248910A1 (fr) |
BR (1) | BR0115474A (fr) |
CA (1) | CA2428753C (fr) |
WO (1) | WO2002040021A2 (fr) |
Families Citing this family (34)
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IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
US6752929B1 (en) * | 1999-05-26 | 2004-06-22 | Johnson Matthey Pharmaceutical Materials, Inc. | Methods of separating FTC isomers and derivatives thereof |
TW200303302A (en) * | 2001-12-19 | 2003-09-01 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
PL212929B1 (pl) * | 2002-10-31 | 2012-12-31 | Metabasis Therapeutics Inc | Pochodna cytarabiny, jej zastosowania oraz kompozycja farmaceutyczna zawierajaca ta pochodna |
WO2004056727A2 (fr) * | 2002-12-19 | 2004-07-08 | Atherogenics, Inc. | Procede de fabrication de derives de chalcone |
EP1620407A2 (fr) * | 2003-04-28 | 2006-02-01 | Idenix (Cayman) Limited | Composes d'oxo-pyrimidine |
US7173129B2 (en) * | 2003-06-06 | 2007-02-06 | Athero Genics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
CA2559552A1 (fr) * | 2004-03-23 | 2005-09-29 | F. Hoffmann-La Roche Ag | Derives benzyl-pyridazinone servant d'inhibiteurs d'une transcriptase inverse non nucleosidique |
WO2006004903A2 (fr) * | 2004-06-28 | 2006-01-12 | Atherogenics, Inc. | 1,2-bis-(phenyl-substitue)-2-propen-1-ones et des compositions pharmaceutiques en contenant |
EP1768660A4 (fr) * | 2004-07-01 | 2009-05-13 | Atherogenics Inc | Composes et methodes de traitement des maladies vasculaires diabetiques |
JP4675959B2 (ja) | 2004-07-27 | 2011-04-27 | エフ.ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としてのベンジルトリアゾロン化合物 |
US8293778B2 (en) | 2004-07-27 | 2012-10-23 | Roche Palo Alto Llc | Heterocyclic antiviral compounds |
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AU2006206274A1 (en) * | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
US7524831B2 (en) * | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
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ITRM20050512A1 (it) * | 2005-10-13 | 2007-04-14 | Univ Siena | Derivati 6-pirimidinici e pirimidinonici, e loro uso. |
US7790364B2 (en) * | 2006-01-27 | 2010-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for high throughput screening of pharmacological chaperones |
CA2681420A1 (fr) * | 2007-03-20 | 2008-09-25 | Cadila Pharmaceuticals Limited | Inhibiteurs de p38 |
BRPI0813709A2 (pt) | 2007-07-09 | 2015-01-06 | Eastern Virginia Med School | Derivados de nucleosídeo substituído com propriedades antiviral e antimicrobiana |
CN102670628B (zh) | 2008-01-25 | 2015-11-25 | 奇默里克斯公司 | 治疗病毒感染的方法 |
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US8367315B2 (en) * | 2010-03-05 | 2013-02-05 | Adan Rios | Inactivation of reverse transcriptases by azido-diarylpyrimidines |
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-
2001
- 2001-11-19 BR BR0115474-5A patent/BR0115474A/pt not_active Application Discontinuation
- 2001-11-19 CA CA2428753A patent/CA2428753C/fr not_active Expired - Fee Related
- 2001-11-19 US US10/001,868 patent/US6545007B2/en not_active Expired - Lifetime
- 2001-11-19 AU AU2002248910A patent/AU2002248910A1/en not_active Abandoned
- 2001-11-19 WO PCT/US2001/045652 patent/WO2002040021A2/fr not_active Application Discontinuation
- 2001-11-19 EP EP01996382A patent/EP1343502A2/fr not_active Withdrawn
-
2003
- 2003-01-24 US US10/350,772 patent/US20030225114A1/en not_active Abandoned
- 2003-05-21 US US10/443,470 patent/US7078431B2/en not_active Expired - Fee Related
-
2006
- 2006-01-05 US US11/327,672 patent/US20060106044A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030008887A1 (en) | 2003-01-09 |
BR0115474A (pt) | 2006-01-31 |
CA2428753A1 (fr) | 2002-05-23 |
CA2428753C (fr) | 2013-05-21 |
US20030236298A1 (en) | 2003-12-25 |
US20030225114A1 (en) | 2003-12-04 |
US7078431B2 (en) | 2006-07-18 |
US6545007B2 (en) | 2003-04-08 |
WO2002040021A3 (fr) | 2002-08-22 |
US20060106044A1 (en) | 2006-05-18 |
EP1343502A2 (fr) | 2003-09-17 |
WO2002040021A2 (fr) | 2002-05-23 |
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