AU2002227495B2 - Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy - Google Patents

Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy Download PDF

Info

Publication number
AU2002227495B2
AU2002227495B2 AU2002227495A AU2002227495A AU2002227495B2 AU 2002227495 B2 AU2002227495 B2 AU 2002227495B2 AU 2002227495 A AU2002227495 A AU 2002227495A AU 2002227495 A AU2002227495 A AU 2002227495A AU 2002227495 B2 AU2002227495 B2 AU 2002227495B2
Authority
AU
Australia
Prior art keywords
compound
group
ala ester
composition
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002227495A
Other languages
English (en)
Other versions
AU2002227495A1 (en
Inventor
Jon Erik Braenden
Aslak Godal
Jo Klaveness
Nils Olav Nilsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photocure ASA
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of AU2002227495A1 publication Critical patent/AU2002227495A1/en
Application granted granted Critical
Publication of AU2002227495B2 publication Critical patent/AU2002227495B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002227495A 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy Ceased AU2002227495B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018528.0 2000-07-27
GBGB0018528.0A GB0018528D0 (en) 2000-07-27 2000-07-27 Compounds
PCT/GB2001/003336 WO2002010120A1 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Publications (2)

Publication Number Publication Date
AU2002227495A1 AU2002227495A1 (en) 2002-05-09
AU2002227495B2 true AU2002227495B2 (en) 2006-01-05

Family

ID=9896500

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002227495A Ceased AU2002227495B2 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
AU2749502A Pending AU2749502A (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2749502A Pending AU2749502A (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Country Status (19)

Country Link
US (2) US7217736B2 (OSRAM)
EP (1) EP1313695B1 (OSRAM)
JP (1) JP5010088B2 (OSRAM)
KR (1) KR20030028554A (OSRAM)
CN (1) CN1318388C (OSRAM)
AT (1) ATE349417T1 (OSRAM)
AU (2) AU2002227495B2 (OSRAM)
CA (1) CA2416307C (OSRAM)
CZ (1) CZ2003260A3 (OSRAM)
DE (1) DE60125555T2 (OSRAM)
DK (1) DK1313695T3 (OSRAM)
ES (1) ES2276844T3 (OSRAM)
GB (1) GB0018528D0 (OSRAM)
HU (1) HUP0301427A2 (OSRAM)
NO (1) NO20030398L (OSRAM)
NZ (1) NZ523927A (OSRAM)
PT (1) PT1313695E (OSRAM)
RU (1) RU2246483C2 (OSRAM)
WO (1) WO2002010120A1 (OSRAM)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492420B2 (en) * 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
CA2348871C (en) * 1998-11-02 2009-04-14 John G. Devane Multiparticulate modified release composition
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
EP1404324B2 (en) 2001-06-11 2011-04-06 XenoPort, Inc. Prodrugs of gaba analogs, compositions and uses thereof
GB0118251D0 (en) * 2001-07-26 2001-09-19 Photocure Asa Method
JP2006501936A (ja) * 2002-10-04 2006-01-19 エラン ファーマ インターナショナル，リミティド 固体ナノ粒子活性薬剤のガンマ線照射
DE10312659A1 (de) * 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
CA2523035C (en) * 2003-05-22 2011-04-26 Elan Pharma International Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
GB0406917D0 (en) * 2004-03-26 2004-04-28 Photocure Asa Compounds
JP2005350418A (ja) * 2004-06-11 2005-12-22 Shibuya Kogyo Co Ltd 標的細胞の死滅方法と標的細胞を死滅させるための薬剤及び該薬剤の製造装置
WO2006025286A1 (ja) 2004-09-02 2006-03-09 Cosmo Oil Co., Ltd. 健康機能向上剤
BRPI0517227B8 (pt) 2004-11-04 2021-05-25 Xenoport Inc comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
EP1855651A4 (en) * 2005-03-03 2011-06-15 Elan Pharma Int Ltd NANOPARTICLE COMPOSITIONS OF HETEROCYCLIC AMID DERIVATIVES
JP4934293B2 (ja) * 2005-07-05 2012-05-16 コスモ石油株式会社 植物活力剤組成物
JP4934292B2 (ja) * 2005-07-05 2012-05-16 コスモ石油株式会社 ５−アミノレブリン酸エステルリン酸類塩、その製造方法及びその用途
GB0609809D0 (en) * 2006-05-17 2006-06-28 Photocure Asa Product
BRPI0714173A2 (pt) * 2006-07-12 2012-12-25 Elan Pharma Int Ltd composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
GB0700580D0 (en) * 2007-01-11 2007-02-21 Photocure Asa Use
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100883560B1 (ko) * 2007-08-23 2009-02-17 (주) 위디어 신규한 5-아미노레불린 산 유도체 및 이의 제조방법
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
AU2008337067A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods
GB0804190D0 (en) * 2008-03-06 2008-04-16 Ge Healthcare Ltd Ester imaging agents
CN102014890B (zh) 2008-05-14 2015-08-05 思佰益药业股份有限公司 男性不育治疗剂
CA2735426A1 (en) * 2008-09-01 2010-03-04 Swedish Pharma Ab New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis
GB0823472D0 (en) 2008-12-23 2009-01-28 Photocure Asa Product
GB0900461D0 (en) 2009-01-12 2009-02-11 Photocure Asa Photodynamic therapy device
US20120136055A1 (en) 2009-06-11 2012-05-31 Photocure Asa Semi-solid compositions and pharmaceutical products
CN102802612A (zh) * 2009-06-11 2012-11-28 光治疗Asa公司 含有5-氨基酮戊酸的固态组合物
WO2011107478A1 (en) 2010-03-01 2011-09-09 Photocure Asa Cosmetic compositions
EP2394642A1 (en) 2010-06-10 2011-12-14 Universite De Geneve 5-ALA ester formulations and use thereof
WO2011161220A1 (en) 2010-06-23 2011-12-29 Photocure Asa Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent
ES2620780T3 (es) 2010-07-09 2017-06-29 Photocure Asa Dispositivos que contienen composiciones secas para su uso en terapia fotodinámica
WO2012086802A1 (ja) 2010-12-24 2012-06-28 アークレイ株式会社 癌細胞の検出方法
US20130289089A1 (en) 2011-01-13 2013-10-31 Jerome A. Morris Pharmaceutical Compositions for Topical Delivery of Photosensitizers and Uses Thereof
EP2779956A1 (en) 2011-10-14 2014-09-24 Photocure ASA Stent
WO2013053927A1 (en) 2011-10-14 2013-04-18 Photocure Asa Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester
KR102057349B1 (ko) 2011-12-19 2019-12-18 포토큐어 에이에스에이 광 조사 기구
WO2013092936A2 (en) 2011-12-20 2013-06-27 Galderma Research & Development Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne
CA2878846A1 (en) 2012-07-11 2014-01-16 Delphine Caroline Imbert Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof
AU2013298525B2 (en) 2012-08-03 2017-12-14 Photocure Asa Compounds
GB201215675D0 (en) 2012-09-03 2012-10-17 Univ Exeter Compound
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
GB201306369D0 (en) 2013-04-09 2013-05-22 Photocure As Irradiation device
CN105899201A (zh) 2013-12-20 2016-08-24 盖尔德马研究及发展公司 光损伤的皮肤的脉冲光动力治疗
SG11201606351VA (en) 2014-02-03 2016-09-29 Quadriga Biosciences Inc Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
EP3095464A1 (en) 2015-05-19 2016-11-23 Universite De Geneve 5-ala derivatives and use thereof
EP3331851A1 (en) 2015-08-03 2018-06-13 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN112010772A (zh) 2016-01-26 2020-12-01 赵鸣 5-氨基酮戊酸及其衍生物的盐化合物和应用
ES2981753T3 (es) 2017-02-06 2024-10-10 3Skin As Composición de filtro solar
EP3641882B1 (en) * 2017-06-21 2023-09-27 Photocure ASA Method for preparing a liquid pharmaceutical composition and device for use in such method
EP3868372A1 (en) 2020-02-19 2021-08-25 JLP Health GmbH A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer
CN111635464B (zh) * 2020-05-12 2022-03-25 上海易全化学有限公司 一种5-氨基酮戊酸葡聚糖酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753487A (ja) * 1993-08-19 1995-02-28 Cosmo Sogo Kenkyusho:Kk 植物成長調節剤
WO1996028412A1 (en) * 1995-03-10 1996-09-19 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
DE2411382C3 (de) 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
GB2058077B (en) 1979-06-08 1983-03-09 Szelke M Enkephalin analogues
CA1236029A (en) 1984-05-14 1988-05-03 Edmund Sandborn Pharmaceutical solutions comprising dimethyl sulfoxide
SE460947B (sv) 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
JPS6452778A (en) * 1987-05-30 1989-02-28 Tokuyama Soda Kk Fulgide compound and production thereof
JPH0745502B2 (ja) * 1987-11-10 1995-05-17 株式会社トクヤマ 新規化合物及びそれを含む組成物
US5422093A (en) 1989-07-28 1995-06-06 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5234940A (en) 1989-07-28 1993-08-10 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5079262A (en) 1989-07-28 1992-01-07 Queen's University At Kingston Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US5955490A (en) 1989-07-28 1999-09-21 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
JP2767318B2 (ja) 1990-04-11 1998-06-18 株式会社コスモ総合研究所 ５―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤
US5219878A (en) 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
CA2093361C (en) 1990-10-05 2002-04-23 Michel Ringuet Porphyrin derivative
GB9318841D0 (en) 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
JP2896963B2 (ja) 1994-11-28 1999-05-31 株式会社コスモ総合研究所 植物の耐塩性向上剤
GB9504948D0 (en) * 1995-03-10 1995-04-26 Norwegian Radium Hospital Rese Compounds
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) * 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
GB9700396D0 (en) * 1997-01-10 1997-02-26 Photocure As Photochemotherapeutic compositions
FR2777782B1 (fr) 1998-04-22 2001-05-18 Alexandre Marti Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires
GB0018527D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Composition
GB0118251D0 (en) 2001-07-26 2001-09-19 Photocure Asa Method
GB0128052D0 (en) 2001-11-22 2002-01-16 Drug Discovery Lab As Compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753487A (ja) * 1993-08-19 1995-02-28 Cosmo Sogo Kenkyusho:Kk 植物成長調節剤
WO1996028412A1 (en) * 1995-03-10 1996-09-19 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Also Published As

Publication number Publication date
ATE349417T1 (de) 2007-01-15
AU2749502A (en) 2002-02-13
DE60125555D1 (de) 2007-02-08
US7563819B1 (en) 2009-07-21
US20040106679A1 (en) 2004-06-03
GB0018528D0 (en) 2000-09-13
DK1313695T3 (da) 2007-04-30
NZ523927A (en) 2004-07-30
CZ2003260A3 (cs) 2003-06-18
DE60125555T2 (de) 2007-10-11
CA2416307A1 (en) 2002-02-07
RU2246483C2 (ru) 2005-02-20
JP2004505105A (ja) 2004-02-19
ES2276844T3 (es) 2007-07-01
KR20030028554A (ko) 2003-04-08
EP1313695B1 (en) 2006-12-27
JP5010088B2 (ja) 2012-08-29
EP1313695A1 (en) 2003-05-28
US7217736B2 (en) 2007-05-15
NO20030398L (no) 2003-03-12
CN1318388C (zh) 2007-05-30
CA2416307C (en) 2013-01-22
WO2002010120A1 (en) 2002-02-07
HUP0301427A2 (hu) 2003-09-29
CN1460099A (zh) 2003-12-03
NO20030398D0 (no) 2003-01-24
PT1313695E (pt) 2007-01-31

Similar Documents

Publication Publication Date Title
AU2002227495B2 (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
AU2002227495A1 (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7287646B2 (en) Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
EP2308830B1 (en) Acid addition salts of 5-aminolevulinic acid or its derivatives
US6034267A (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7247655B2 (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired