JP5010088B2 - 光化学治療における光増感剤としての5−アミノレブリン酸のエステル - Google Patents

光化学治療における光増感剤としての5−アミノレブリン酸のエステル Download PDF

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JP5010088B2
JP5010088B2 JP2002516252A JP2002516252A JP5010088B2 JP 5010088 B2 JP5010088 B2 JP 5010088B2 JP 2002516252 A JP2002516252 A JP 2002516252A JP 2002516252 A JP2002516252 A JP 2002516252A JP 5010088 B2 JP5010088 B2 JP 5010088B2
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ala
ester
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alkyl group
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JP2004505105A (ja
JP2004505105A5 (OSRAM
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ジョー クラベネス
ニルズ オラブ ニルセン
ジョン エリック ブリーンデン
アスラック ゴーダル
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フォトキュア エイエスエイ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/00615-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002516252A 2000-07-27 2001-07-25 光化学治療における光増感剤としての5−アミノレブリン酸のエステル Expired - Fee Related JP5010088B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018528.0 2000-07-27
GBGB0018528.0A GB0018528D0 (en) 2000-07-27 2000-07-27 Compounds
PCT/GB2001/003336 WO2002010120A1 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Publications (3)

Publication Number Publication Date
JP2004505105A JP2004505105A (ja) 2004-02-19
JP2004505105A5 JP2004505105A5 (OSRAM) 2005-04-14
JP5010088B2 true JP5010088B2 (ja) 2012-08-29

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JP2002516252A Expired - Fee Related JP5010088B2 (ja) 2000-07-27 2001-07-25 光化学治療における光増感剤としての5−アミノレブリン酸のエステル

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US (2) US7217736B2 (OSRAM)
EP (1) EP1313695B1 (OSRAM)
JP (1) JP5010088B2 (OSRAM)
KR (1) KR20030028554A (OSRAM)
CN (1) CN1318388C (OSRAM)
AT (1) ATE349417T1 (OSRAM)
AU (2) AU2002227495B2 (OSRAM)
CA (1) CA2416307C (OSRAM)
CZ (1) CZ2003260A3 (OSRAM)
DE (1) DE60125555T2 (OSRAM)
DK (1) DK1313695T3 (OSRAM)
ES (1) ES2276844T3 (OSRAM)
GB (1) GB0018528D0 (OSRAM)
HU (1) HUP0301427A2 (OSRAM)
NO (1) NO20030398L (OSRAM)
NZ (1) NZ523927A (OSRAM)
PT (1) PT1313695E (OSRAM)
RU (1) RU2246483C2 (OSRAM)
WO (1) WO2002010120A1 (OSRAM)

Cited By (1)

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US9645154B2 (en) 2010-12-24 2017-05-09 Arkray, Inc. Method for detecting cancer cell

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ATE349417T1 (de) 2007-01-15
AU2749502A (en) 2002-02-13
DE60125555D1 (de) 2007-02-08
US7563819B1 (en) 2009-07-21
US20040106679A1 (en) 2004-06-03
GB0018528D0 (en) 2000-09-13
AU2002227495B2 (en) 2006-01-05
DK1313695T3 (da) 2007-04-30
NZ523927A (en) 2004-07-30
CZ2003260A3 (cs) 2003-06-18
DE60125555T2 (de) 2007-10-11
CA2416307A1 (en) 2002-02-07
RU2246483C2 (ru) 2005-02-20
JP2004505105A (ja) 2004-02-19
ES2276844T3 (es) 2007-07-01
KR20030028554A (ko) 2003-04-08
EP1313695B1 (en) 2006-12-27
EP1313695A1 (en) 2003-05-28
US7217736B2 (en) 2007-05-15
NO20030398L (no) 2003-03-12
CN1318388C (zh) 2007-05-30
CA2416307C (en) 2013-01-22
WO2002010120A1 (en) 2002-02-07
HUP0301427A2 (hu) 2003-09-29
CN1460099A (zh) 2003-12-03
NO20030398D0 (no) 2003-01-24
PT1313695E (pt) 2007-01-31

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