AU2001272597B9 - Coumarin derivatives with comt inhibiting activity - Google Patents

Coumarin derivatives with comt inhibiting activity Download PDF

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Publication number
AU2001272597B9
AU2001272597B9 AU2001272597A AU2001272597A AU2001272597B9 AU 2001272597 B9 AU2001272597 B9 AU 2001272597B9 AU 2001272597 A AU2001272597 A AU 2001272597A AU 2001272597 A AU2001272597 A AU 2001272597A AU 2001272597 B9 AU2001272597 B9 AU 2001272597B9
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AU
Australia
Prior art keywords
alkyl
compound
cooh
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001272597A
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English (en)
Other versions
AU2001272597B2 (en
AU2001272597A1 (en
Inventor
Timo Lotta
Martti Ovaska
Jarmo Pystynen
Jukka Vidgren
Marjo Yliperttula-Ikonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of AU2001272597A1 publication Critical patent/AU2001272597A1/en
Publication of AU2001272597B2 publication Critical patent/AU2001272597B2/en
Application granted granted Critical
Publication of AU2001272597B9 publication Critical patent/AU2001272597B9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001272597A 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity Ceased AU2001272597B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20001593A FI20001593A7 (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
FI20001593 2000-07-03
PCT/FI2001/000613 WO2002002548A1 (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Publications (3)

Publication Number Publication Date
AU2001272597A1 AU2001272597A1 (en) 2002-04-11
AU2001272597B2 AU2001272597B2 (en) 2005-07-21
AU2001272597B9 true AU2001272597B9 (en) 2005-08-11

Family

ID=8558717

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001272597A Ceased AU2001272597B9 (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity
AU7259701A Pending AU7259701A (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU7259701A Pending AU7259701A (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Country Status (27)

Country Link
US (1) US6951870B2 (enExample)
EP (1) EP1301503B1 (enExample)
JP (1) JP4851051B2 (enExample)
KR (1) KR20030040225A (enExample)
CN (1) CN1199963C (enExample)
AT (1) ATE260268T1 (enExample)
AU (2) AU2001272597B9 (enExample)
BG (1) BG107513A (enExample)
BR (1) BR0111969A (enExample)
CA (1) CA2414787C (enExample)
DE (1) DE60102161T2 (enExample)
DK (1) DK1301503T3 (enExample)
EE (1) EE200300008A (enExample)
ES (1) ES2215919T3 (enExample)
FI (1) FI20001593A7 (enExample)
HU (1) HUP0301706A3 (enExample)
IL (2) IL153352A0 (enExample)
MX (1) MXPA02012657A (enExample)
NO (1) NO328699B1 (enExample)
NZ (1) NZ523121A (enExample)
PL (1) PL359068A1 (enExample)
PT (1) PT1301503E (enExample)
RU (1) RU2282627C2 (enExample)
SK (1) SK18452002A3 (enExample)
TR (1) TR200400802T4 (enExample)
WO (1) WO2002002548A1 (enExample)
ZA (1) ZA200210161B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
CN1506359A (zh) 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
CN101056868B (zh) 2004-09-21 2012-05-02 马休爱德华兹股份有限公司 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
RU2396244C1 (ru) * 2008-12-23 2010-08-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Способ получения пурпурогаллина
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
WO2012061409A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
PT3253208T (pt) 2015-02-02 2021-06-17 The Spanish National Cancer Res Centre Terapêuticas de combinação para utilização no tratamento do cancro da mama
JP7007292B2 (ja) * 2015-12-18 2022-02-10 ケスター、ヒューバート 薬剤としての使用のため、特にパーキンソン病の治療のための新規二環式化合物
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺
CN116064607B (zh) * 2022-08-22 2025-04-18 西南大学 一种高活性o-甲基转移酶基因制备滨蒿内酯的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5035393A (enExample) * 1973-08-01 1975-04-04
US3973608A (en) 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) * 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors
HRP970529B1 (en) * 1997-10-02 2003-06-30 Pliva Pharm & Chem Works Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Also Published As

Publication number Publication date
NZ523121A (en) 2004-08-27
JP2004502684A (ja) 2004-01-29
ZA200210161B (en) 2004-03-15
TR200400802T4 (tr) 2004-07-21
BG107513A (bg) 2003-06-30
US20030186975A1 (en) 2003-10-02
AU7259701A (en) 2002-01-14
EE200300008A (et) 2004-08-16
SK18452002A3 (sk) 2004-04-06
CN1440399A (zh) 2003-09-03
FI20001593A0 (fi) 2000-07-03
US6951870B2 (en) 2005-10-04
AU2001272597B2 (en) 2005-07-21
RU2282627C2 (ru) 2006-08-27
ATE260268T1 (de) 2004-03-15
CA2414787C (en) 2010-12-14
HUP0301706A2 (hu) 2003-09-29
KR20030040225A (ko) 2003-05-22
BR0111969A (pt) 2003-07-01
US20040110750A9 (en) 2004-06-10
DK1301503T3 (da) 2004-06-28
NO328699B1 (no) 2010-04-26
EP1301503B1 (en) 2004-02-25
EP1301503A1 (en) 2003-04-16
ES2215919T3 (es) 2004-10-16
PT1301503E (pt) 2004-06-30
DE60102161D1 (de) 2004-04-01
NO20026095L (no) 2003-03-03
FI20001593A7 (fi) 2002-01-04
NO20026095D0 (no) 2002-12-18
HUP0301706A3 (en) 2005-12-28
CN1199963C (zh) 2005-05-04
IL153352A (en) 2009-05-04
DE60102161T2 (de) 2004-09-16
JP4851051B2 (ja) 2012-01-11
PL359068A1 (pl) 2004-08-23
CA2414787A1 (en) 2002-01-10
IL153352A0 (en) 2003-07-06
MXPA02012657A (es) 2003-05-14
WO2002002548A1 (en) 2002-01-10

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Legal Events

Date Code Title Description
SREP Specification republished
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired