AU2001270928A1 - Process for the preparation of highly pure crystalline (R,S) - cefuroxime axetil - Google Patents

Process for the preparation of highly pure crystalline (R,S) - cefuroxime axetil

Info

Publication number
AU2001270928A1
AU2001270928A1 AU2001270928A AU7092801A AU2001270928A1 AU 2001270928 A1 AU2001270928 A1 AU 2001270928A1 AU 2001270928 A AU2001270928 A AU 2001270928A AU 7092801 A AU7092801 A AU 7092801A AU 2001270928 A1 AU2001270928 A1 AU 2001270928A1
Authority
AU
Australia
Prior art keywords
solvent
cefuroxime
group
amine
cefuroxime axetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001270928A
Other languages
English (en)
Inventor
Vijay Kumar Handa
Om Dutt Tyagi
Gyan Chand Yadav
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of AU2001270928A1 publication Critical patent/AU2001270928A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001270928A 2000-07-17 2001-07-16 Process for the preparation of highly pure crystalline (R,S) - cefuroxime axetil Abandoned AU2001270928A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN653/DEL/2000 2000-07-17
IN653DE2000 IN190849B (enExample) 2000-07-17 2000-07-17
PCT/IB2001/001259 WO2002006289A1 (en) 2000-07-17 2001-07-16 Process for the preparation of highly pure crystalline (r,s) - cefuroxime axetil

Publications (1)

Publication Number Publication Date
AU2001270928A1 true AU2001270928A1 (en) 2002-01-30

Family

ID=11097069

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001270928A Abandoned AU2001270928A1 (en) 2000-07-17 2001-07-16 Process for the preparation of highly pure crystalline (R,S) - cefuroxime axetil

Country Status (10)

Country Link
US (1) US6833452B2 (enExample)
EP (1) EP1303523A1 (enExample)
JP (1) JP2004504325A (enExample)
CN (1) CN1447812A (enExample)
AU (1) AU2001270928A1 (enExample)
BR (1) BR0112598A (enExample)
CA (1) CA2416695A1 (enExample)
IN (1) IN190849B (enExample)
WO (1) WO2002006289A1 (enExample)
ZA (1) ZA200300472B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
CA2433067C (en) * 2001-07-25 2010-04-27 Lupin Limited An improved method for preparation of cefuroxime axetil
US6537985B1 (en) 2001-11-30 2003-03-25 Phoenix Scientific, Inc. Antibiotic formulation and a method of making this formulation
US20030135041A1 (en) 2002-01-04 2003-07-17 Orchid Chemicals & Pharmaceuticals Limited, India Synthesis of ceftiofur intermediate
CN100448879C (zh) 2004-07-22 2009-01-07 北京化工大学 一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
ITMI20050871A1 (it) * 2005-05-13 2006-11-14 Acs Dobfar Spa Solvato cristallino di cefuroxima acido
DE102006019619A1 (de) * 2006-04-25 2007-10-31 Grünenthal GmbH Kristalline Modifikation von Cefuroximaxetil
CN103435632B (zh) * 2013-09-12 2016-03-02 广东立国制药有限公司 一种头孢呋辛酯的制备方法
CN105131016A (zh) * 2015-08-04 2015-12-09 江苏正大清江制药有限公司 一种头孢呋辛酯的制备方法
CN106554361B (zh) * 2016-09-30 2018-10-09 华北制药河北华民药业有限责任公司 一种头孢呋辛酯口服制剂的制备方法
CN108586493A (zh) * 2017-12-18 2018-09-28 蚌埠丰原医药科技发展有限公司 一种结晶型头孢呋辛酯的制备方法
CN109705143A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯提纯的方法
CN109705144A (zh) * 2019-03-05 2019-05-03 安徽丰原利康制药有限公司 一种头孢呋辛酯高得率的生产方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1094545A (en) 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
YU44680B (en) 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
JPH02104590A (ja) * 1987-06-15 1990-04-17 Toyohiko Kikuchi 抗生物質の製造方法
US5063224A (en) 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
JP3121903B2 (ja) * 1992-02-07 2001-01-09 塩野義製薬株式会社 デアセチルセファロスポラン酸のカルバモイル化方法
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
DE59900787D1 (de) * 1998-02-20 2002-03-14 Fako Ilaclari A S Verfahren zur Herstellung vom löslichen kristallinen Cefuroxim axetil
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
CA2433067C (en) * 2001-07-25 2010-04-27 Lupin Limited An improved method for preparation of cefuroxime axetil

Also Published As

Publication number Publication date
EP1303523A1 (en) 2003-04-23
US6833452B2 (en) 2004-12-21
WO2002006289A1 (en) 2002-01-24
CN1447812A (zh) 2003-10-08
CA2416695A1 (en) 2002-01-24
JP2004504325A (ja) 2004-02-12
IN190849B (enExample) 2003-08-23
ZA200300472B (en) 2003-10-16
BR0112598A (pt) 2003-08-12
US20020016456A1 (en) 2002-02-07

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application