AU1721801A - Method for the preparation of purified hcv rna by exosome separation - Google Patents
Method for the preparation of purified hcv rna by exosome separationInfo
- Publication number
- AU1721801A AU1721801A AU17218/01A AU1721801A AU1721801A AU 1721801 A AU1721801 A AU 1721801A AU 17218/01 A AU17218/01 A AU 17218/01A AU 1721801 A AU1721801 A AU 1721801A AU 1721801 A AU1721801 A AU 1721801A
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- hcv rna
- purified hcv
- exosome separation
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000001808 exosome Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24251—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9927320 | 1999-11-18 | ||
| GBGB9927320.3A GB9927320D0 (en) | 1999-11-18 | 1999-11-18 | Exosome separation |
| PCT/IB2000/001801 WO2001036601A1 (en) | 1999-11-18 | 2000-11-20 | Method for the preparation of purified hcv rna by exosome separation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU1721801A true AU1721801A (en) | 2001-05-30 |
Family
ID=10864765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU17218/01A Abandoned AU1721801A (en) | 1999-11-18 | 2000-11-20 | Method for the preparation of purified hcv rna by exosome separation |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7198923B1 (enExample) |
| EP (1) | EP1230347B1 (enExample) |
| JP (1) | JP4675017B2 (enExample) |
| AT (1) | ATE373084T1 (enExample) |
| AU (1) | AU1721801A (enExample) |
| CA (1) | CA2392075C (enExample) |
| CY (1) | CY1107521T1 (enExample) |
| DE (1) | DE60036403T2 (enExample) |
| DK (1) | DK1230347T3 (enExample) |
| ES (1) | ES2292489T3 (enExample) |
| GB (1) | GB9927320D0 (enExample) |
| PT (1) | PT1230347E (enExample) |
| WO (1) | WO2001036601A1 (enExample) |
Families Citing this family (89)
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|---|---|---|---|---|
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| EP1766053A4 (en) * | 2004-06-02 | 2007-12-12 | Sourcepharm Inc | MICROVESICLES CONTAINING RNA AND METHODS |
| US8021847B2 (en) | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| ES2736726T3 (es) * | 2006-03-09 | 2020-01-07 | Aethlon Medical Inc | Eliminación extracorpórea de partículas microvesiculares |
| US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
| US8617806B2 (en) * | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
| EP2604704B1 (en) * | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
| US20110195426A1 (en) | 2009-07-16 | 2011-08-11 | The General Hospital Corporation | Nucleic acids analysis |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| EP2310529A2 (en) * | 2008-06-20 | 2011-04-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| US10545149B2 (en) * | 2008-10-06 | 2020-01-28 | Morehouse School Of Medicine | Detection of HIV-related proteins in urine |
| US9487837B2 (en) | 2008-10-06 | 2016-11-08 | Morehouse School Of Medicine | Exosome-mediated diagnosis of hepatitis virus infections and diseases |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| ES2927225T3 (es) | 2009-04-17 | 2022-11-03 | Univ Oxford Innovation Ltd | Composición para entrega de material genético |
| BRPI0900815A2 (pt) * | 2009-04-23 | 2010-12-28 | Sociedade Benef Israelita Bras Hospital Albert Einstein | método para isolamento de exossomos a partir de soluções biológicas utilizando nanopartìculas de óxido de ferro |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| EP3461912B1 (en) | 2009-09-09 | 2022-07-13 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| JPWO2011049059A1 (ja) * | 2009-10-22 | 2013-03-14 | 国立大学法人岐阜大学 | Rna内包キャリア組成物 |
| EP2507393A4 (en) | 2009-11-30 | 2013-05-01 | Caris Life Sciences Luxembourg Holdings | METHODS AND SYSTEMS FOR ISOLATING, STORING AND ANALYZING VESICLES |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| WO2011156734A2 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
| JP5755326B2 (ja) | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| WO2012006476A2 (en) | 2010-07-07 | 2012-01-12 | Aethlon Medical, Inc. | Methods and compositions for quantifying exosomes |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| EP2638057B1 (en) | 2010-11-10 | 2019-03-06 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| EP3569607A1 (en) * | 2011-05-11 | 2019-11-20 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| WO2012170037A1 (en) | 2011-06-10 | 2012-12-13 | Hitachi Chemical Co., Ltd. | Vesicle capturing devices and methods for using same |
| CA2839896A1 (en) | 2011-06-21 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
| EP2748335B1 (en) | 2011-08-22 | 2018-10-03 | Exosome Diagnostics, Inc. | Urine biomarkers |
| EP2758774A4 (en) * | 2011-09-22 | 2015-04-29 | Univ Los Andes | METHOD FOR MONITORING, DIAGNOSIS AND / OR FORECASTING ACUTE CHILDIER INJURY IN AN EARLY STAGE |
| US10174361B2 (en) | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
| GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
| EP3299814A3 (en) * | 2012-07-19 | 2018-04-11 | Atlantic Cancer Research Institute | Method for the isolation of microvesicles |
| CN104995311A (zh) | 2012-08-30 | 2015-10-21 | 外来体诊断公司 | 用于核酸测定的对照 |
| CN105025878A (zh) | 2012-10-03 | 2015-11-04 | 外来体诊断公司 | 微泡在医学疾病和病况的诊断、预后和治疗中的用途 |
| DK2906717T3 (en) | 2012-10-11 | 2019-04-01 | Vin De Bona Trading Company Pte Ltd | PROCEDURE FOR PAINTING MICROVESICS |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| BR112015016136A2 (pt) | 2013-01-03 | 2017-07-11 | Exosome Diagnostics Inc | métodos para isolar microvesículas |
| CN105209881B (zh) | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| DE212013000295U1 (de) | 2013-05-06 | 2016-02-02 | Hitachi Chemical Co. America, Ltd. | Vorrichtungen zum Einfangen von Zielmolekülen |
| US10301681B2 (en) | 2013-08-06 | 2019-05-28 | Exosome Diagnostics, Inc. | Methods of treating a subject with a high gleason score prostate cancer |
| US20160319361A1 (en) | 2013-08-28 | 2016-11-03 | Caris Life Sciences Switzerland Holdings Gmbh | Oligonucleotide probes and uses thereof |
| TWI708058B (zh) * | 2013-10-24 | 2020-10-21 | 美商納諾索米克斯公司 | 阿茲海默症及其他神經退化性疾病之生物標記及診斷方法 |
| CN106029898B (zh) * | 2014-01-21 | 2020-02-28 | 莫尔豪斯医学院 | 外来体介导的感染和疾病的检测 |
| EP3125907A4 (en) | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| US11268085B2 (en) | 2014-05-27 | 2022-03-08 | Exosome Diagnostics, Inc. | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| CA2954576C (en) | 2014-07-09 | 2020-08-11 | Daniel ENDERLE | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| ES2825708T3 (es) | 2014-07-17 | 2021-05-17 | Univ Pennsylvania | Métodos para usar exosomas para monitorizar el estado de órgano trasplantado |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
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| EP3112474A1 (en) | 2015-06-29 | 2017-01-04 | Evonik Degussa GmbH | Method of detecting avian necrotic enteritis |
| WO2016145128A1 (en) | 2015-03-09 | 2016-09-15 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
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| US10590425B2 (en) | 2015-06-29 | 2020-03-17 | Caris Science, Inc. | Therapeutic oligonucleotides |
| US10941176B2 (en) | 2015-07-28 | 2021-03-09 | Caris Science, Inc. | Therapeutic oligonucleotides |
| WO2017040520A1 (en) | 2015-08-31 | 2017-03-09 | Hitachi Chemical Co., Ltd. | Molecular methods for assessing urothelial disease |
| EP3165926A1 (en) | 2015-11-06 | 2017-05-10 | Humanitas Mirasole S.p.A. | Method for characterization of cell specific microvesicles |
| US11702702B2 (en) | 2016-04-15 | 2023-07-18 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| KR20190020649A (ko) | 2016-04-15 | 2019-03-04 | 엑소좀 디아그노스틱스, 인크. | 역형성 림프종 키나아제(alk) 핵산 및 alk 융합 전사물의 혈장 기반 검출 및 암의 진단 및 치료에 있어 이의 용도 |
| KR102741603B1 (ko) | 2016-05-02 | 2024-12-16 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
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| CN110945145B (zh) | 2017-05-17 | 2024-06-11 | 外来体诊断公司 | 微泡核酸和/或蛋白及其作为肾移植排斥的标志物的应用 |
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| KR102556494B1 (ko) | 2017-10-31 | 2023-07-18 | 엔코디아, 인코포레이티드 | 핵산 암호화 및/또는 표지를 이용한 분석용 키트 |
| WO2019094578A1 (en) | 2017-11-09 | 2019-05-16 | Alnylam Pharmaceuticals Inc. | Assays and methods for determining expression of the lect2 gene |
| CN110123838B (zh) * | 2018-02-02 | 2022-04-01 | 上海睿泰生物科技股份有限公司 | 负载白藜芦醇的人多能干细胞外泌体及其制备方法与用途 |
| CN110123841A (zh) * | 2018-02-09 | 2019-08-16 | 上海市第六人民医院 | 负载白藜芦醇的人多能干细胞外泌体在制备治疗生殖系统疾病药物的用途 |
| CA3092472A1 (en) | 2018-03-02 | 2019-09-06 | Evonik Operations Gmbh | In vitro method for detecting intestinal barrier failure in animals |
| US12378608B2 (en) | 2018-06-06 | 2025-08-05 | Exosome Diagnostics, Inc. | Methods for developing urine biomarkers and for detecting bladder cancer |
| WO2020106853A1 (en) | 2018-11-20 | 2020-05-28 | Exosome Diagnostics, Inc. | Compositions and methods for internal controls of microvesicle isolations |
| ES2938227T3 (es) | 2018-12-14 | 2023-04-05 | Evonik Operations Gmbh | Método in vitro de detección de disbiosis intestinal aviar |
| EP3963070A4 (en) | 2019-04-30 | 2023-02-22 | Encodia, Inc. | METHODS OF PREPARATION OF ANALYTES AND RELATED KITS |
| WO2021055770A2 (en) * | 2019-09-18 | 2021-03-25 | Exosome Diagnostics, Inc. | Compositions, methods, and kits for the isolation of extracellular vesicles |
| AU2021255132A1 (en) | 2020-04-13 | 2022-12-08 | Exoprother Medical Ltd. | Cell-derived vesicles comprising wild-type P53 protein for antiviral therapy |
| US20210322483A1 (en) | 2020-04-16 | 2021-10-21 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
| IL277743A (en) | 2020-10-01 | 2022-04-01 | Yeda Res & Dev | A method for diagnosing breast cancer |
| TW202214851A (zh) * | 2020-10-07 | 2022-04-16 | 國立中央大學 | 外泌體核酸萃取方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0185373B1 (ko) * | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| WO1991015574A1 (en) | 1990-04-03 | 1991-10-17 | Southwest Foundation For Biomedical Research | Purified hcv and hcv proteins and peptides |
| GB9416671D0 (en) | 1994-08-17 | 1994-10-12 | Biocine Spa | Assay |
| EP0841945B1 (en) * | 1995-08-03 | 2006-03-08 | Rijksuniversiteit te Leiden | Cell derived antigen presenting vesicles |
| GB9517926D0 (en) | 1995-09-01 | 1995-11-01 | Biocine Spa | Binding protein |
| FR2766205B1 (fr) * | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| DE69841322D1 (de) * | 1997-10-06 | 2010-01-07 | Novartis Vaccines & Diagnostic | Hepatitis c rezeptorprotein cd81 |
| DE69836758T2 (de) * | 1997-11-06 | 2007-10-11 | Innogenetics N.V. | Apo b, annexin v und tubulin: medizinische und diagnostische verwendung und verwendung zur purifikation von hcv |
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
-
1999
- 1999-11-18 GB GBGB9927320.3A patent/GB9927320D0/en not_active Ceased
-
2000
- 2000-11-20 US US10/130,467 patent/US7198923B1/en not_active Expired - Lifetime
- 2000-11-20 EP EP00979837A patent/EP1230347B1/en not_active Expired - Lifetime
- 2000-11-20 CA CA2392075A patent/CA2392075C/en not_active Expired - Lifetime
- 2000-11-20 WO PCT/IB2000/001801 patent/WO2001036601A1/en not_active Ceased
- 2000-11-20 DK DK00979837T patent/DK1230347T3/da active
- 2000-11-20 JP JP2001538480A patent/JP4675017B2/ja not_active Expired - Fee Related
- 2000-11-20 AU AU17218/01A patent/AU1721801A/en not_active Abandoned
- 2000-11-20 AT AT00979837T patent/ATE373084T1/de active
- 2000-11-20 PT PT00979837T patent/PT1230347E/pt unknown
- 2000-11-20 DE DE60036403T patent/DE60036403T2/de not_active Expired - Lifetime
- 2000-11-20 ES ES00979837T patent/ES2292489T3/es not_active Expired - Lifetime
-
2007
- 2007-01-30 US US11/699,925 patent/US7807438B2/en not_active Expired - Fee Related
- 2007-12-07 CY CY20071101559T patent/CY1107521T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1230347B1 (en) | 2007-09-12 |
| DE60036403T2 (de) | 2008-06-12 |
| US7807438B2 (en) | 2010-10-05 |
| CA2392075C (en) | 2011-01-04 |
| JP4675017B2 (ja) | 2011-04-20 |
| DE60036403D1 (de) | 2007-10-25 |
| DK1230347T3 (da) | 2007-11-05 |
| JP2003514523A (ja) | 2003-04-22 |
| ATE373084T1 (de) | 2007-09-15 |
| US7198923B1 (en) | 2007-04-03 |
| GB9927320D0 (en) | 2000-01-12 |
| EP1230347A1 (en) | 2002-08-14 |
| WO2001036601A1 (en) | 2001-05-25 |
| CY1107521T1 (el) | 2013-03-13 |
| ES2292489T3 (es) | 2008-03-16 |
| CA2392075A1 (en) | 2001-05-25 |
| PT1230347E (pt) | 2007-12-20 |
| US20070254351A1 (en) | 2007-11-01 |
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