GB9927320D0 - Exosome separation - Google Patents

Exosome separation

Info

Publication number
GB9927320D0
GB9927320D0 GBGB9927320.3A GB9927320A GB9927320D0 GB 9927320 D0 GB9927320 D0 GB 9927320D0 GB 9927320 A GB9927320 A GB 9927320A GB 9927320 D0 GB9927320 D0 GB 9927320D0
Authority
GB
United Kingdom
Prior art keywords
exosome separation
hepatitis
virus
separation
exosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB9927320.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron SRL filed Critical Chiron SRL
Priority to GBGB9927320.3A priority Critical patent/GB9927320D0/en
Publication of GB9927320D0 publication Critical patent/GB9927320D0/en
Priority to US10/130,467 priority patent/US7198923B1/en
Priority to PT00979837T priority patent/PT1230347E/pt
Priority to EP00979837A priority patent/EP1230347B1/en
Priority to ES00979837T priority patent/ES2292489T3/es
Priority to JP2001538480A priority patent/JP4675017B2/ja
Priority to CA2392075A priority patent/CA2392075C/en
Priority to PCT/IB2000/001801 priority patent/WO2001036601A1/en
Priority to DE60036403T priority patent/DE60036403T2/de
Priority to DK00979837T priority patent/DK1230347T3/da
Priority to AT00979837T priority patent/ATE373084T1/de
Priority to AU17218/01A priority patent/AU1721801A/en
Priority to US11/699,925 priority patent/US7807438B2/en
Priority to CY20071101559T priority patent/CY1107521T1/el
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GBGB9927320.3A 1999-11-18 1999-11-18 Exosome separation Ceased GB9927320D0 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GBGB9927320.3A GB9927320D0 (en) 1999-11-18 1999-11-18 Exosome separation
AU17218/01A AU1721801A (en) 1999-11-18 2000-11-20 Method for the preparation of purified hcv rna by exosome separation
CA2392075A CA2392075C (en) 1999-11-18 2000-11-20 Method for the preparation of purified hcv rna by exosome separation
DE60036403T DE60036403T2 (de) 1999-11-18 2000-11-20 Verfahren zur Herstellung von gereinigter HCV-RNA durch Isolierung von Exosomen
EP00979837A EP1230347B1 (en) 1999-11-18 2000-11-20 Method for the preparation of purified hcv rna by exosome separation
ES00979837T ES2292489T3 (es) 1999-11-18 2000-11-20 Procedimiento para la preparacion de arn de vhc purificado por separacion de exosomas.
JP2001538480A JP4675017B2 (ja) 1999-11-18 2000-11-20 エキソソーム分離によって精製hcvrnaを調製するための方法
US10/130,467 US7198923B1 (en) 1999-11-18 2000-11-20 Method for the preparation of purified HCV RNA by exosome separation
PCT/IB2000/001801 WO2001036601A1 (en) 1999-11-18 2000-11-20 Method for the preparation of purified hcv rna by exosome separation
PT00979837T PT1230347E (pt) 1999-11-18 2000-11-20 Método de preparação de rna do hcv purificado por separação de exossomas
DK00979837T DK1230347T3 (da) 1999-11-18 2000-11-20 Fremgangsmåde til fremstilling af oprenset HCV-RNA ved exosomseparering
AT00979837T ATE373084T1 (de) 1999-11-18 2000-11-20 Verfahren zur herstellung von gereinigtem hcv rna durch isolierung von exosomen
US11/699,925 US7807438B2 (en) 1999-11-18 2007-01-30 Preparation of purified exosomes comprising HCV RNA
CY20071101559T CY1107521T1 (el) 1999-11-18 2007-12-07 Μεθοδος για την παρασκευη καθαρισμενου hcv rna με διαχωρισμο εξωσωματων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9927320.3A GB9927320D0 (en) 1999-11-18 1999-11-18 Exosome separation

Publications (1)

Publication Number Publication Date
GB9927320D0 true GB9927320D0 (en) 2000-01-12

Family

ID=10864765

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9927320.3A Ceased GB9927320D0 (en) 1999-11-18 1999-11-18 Exosome separation

Country Status (13)

Country Link
US (2) US7198923B1 (enExample)
EP (1) EP1230347B1 (enExample)
JP (1) JP4675017B2 (enExample)
AT (1) ATE373084T1 (enExample)
AU (1) AU1721801A (enExample)
CA (1) CA2392075C (enExample)
CY (1) CY1107521T1 (enExample)
DE (1) DE60036403T2 (enExample)
DK (1) DK1230347T3 (enExample)
ES (1) ES2292489T3 (enExample)
GB (1) GB9927320D0 (enExample)
PT (1) PT1230347E (enExample)
WO (1) WO2001036601A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110123841A (zh) * 2018-02-09 2019-08-16 上海市第六人民医院 负载白藜芦醇的人多能干细胞外泌体在制备治疗生殖系统疾病药物的用途
CN110123838A (zh) * 2018-02-02 2019-08-16 上海睿泰生物科技股份有限公司 负载白藜芦醇的人多能干细胞外泌体及其制备方法与用途

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
ES2736726T3 (es) * 2006-03-09 2020-01-07 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
EP2604704B1 (en) * 2008-02-01 2018-10-03 The General Hospital Corporation Use of microvesicles in diagnosis and prognosis of brain tumor
US20110195426A1 (en) 2009-07-16 2011-08-11 The General Hospital Corporation Nucleic acids analysis
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
EP2310529A2 (en) * 2008-06-20 2011-04-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US10545149B2 (en) * 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
US9487837B2 (en) 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US7888035B2 (en) 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
EP3181705A1 (en) * 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
ES2927225T3 (es) 2009-04-17 2022-11-03 Univ Oxford Innovation Ltd Composición para entrega de material genético
BRPI0900815A2 (pt) * 2009-04-23 2010-12-28 Sociedade Benef Israelita Bras Hospital Albert Einstein método para isolamento de exossomos a partir de soluções biológicas utilizando nanopartìculas de óxido de ferro
EP2475989A4 (en) 2009-09-09 2013-02-27 Gen Hospital Corp USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS
EP3461912B1 (en) 2009-09-09 2022-07-13 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
JPWO2011049059A1 (ja) * 2009-10-22 2013-03-14 国立大学法人岐阜大学 Rna内包キャリア組成物
EP2507393A4 (en) 2009-11-30 2013-05-01 Caris Life Sciences Luxembourg Holdings METHODS AND SYSTEMS FOR ISOLATING, STORING AND ANALYZING VESICLES
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
JP5755326B2 (ja) 2010-06-11 2015-07-29 日立化成株式会社 腎機能の特徴を決定する方法
WO2012006476A2 (en) 2010-07-07 2012-01-12 Aethlon Medical, Inc. Methods and compositions for quantifying exosomes
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
EP2638057B1 (en) 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
EP3569607A1 (en) * 2011-05-11 2019-11-20 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
WO2012170037A1 (en) 2011-06-10 2012-12-13 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
CA2839896A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
EP2748335B1 (en) 2011-08-22 2018-10-03 Exosome Diagnostics, Inc. Urine biomarkers
EP2758774A4 (en) * 2011-09-22 2015-04-29 Univ Los Andes METHOD FOR MONITORING, DIAGNOSIS AND / OR FORECASTING ACUTE CHILDIER INJURY IN AN EARLY STAGE
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
EP3299814A3 (en) * 2012-07-19 2018-04-11 Atlantic Cancer Research Institute Method for the isolation of microvesicles
CN104995311A (zh) 2012-08-30 2015-10-21 外来体诊断公司 用于核酸测定的对照
CN105025878A (zh) 2012-10-03 2015-11-04 外来体诊断公司 微泡在医学疾病和病况的诊断、预后和治疗中的用途
DK2906717T3 (en) 2012-10-11 2019-04-01 Vin De Bona Trading Company Pte Ltd PROCEDURE FOR PAINTING MICROVESICS
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
BR112015016136A2 (pt) 2013-01-03 2017-07-11 Exosome Diagnostics Inc métodos para isolar microvesículas
CN105209881B (zh) 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
DE212013000295U1 (de) 2013-05-06 2016-02-02 Hitachi Chemical Co. America, Ltd. Vorrichtungen zum Einfangen von Zielmolekülen
US10301681B2 (en) 2013-08-06 2019-05-28 Exosome Diagnostics, Inc. Methods of treating a subject with a high gleason score prostate cancer
US20160319361A1 (en) 2013-08-28 2016-11-03 Caris Life Sciences Switzerland Holdings Gmbh Oligonucleotide probes and uses thereof
TWI708058B (zh) * 2013-10-24 2020-10-21 美商納諾索米克斯公司 阿茲海默症及其他神經退化性疾病之生物標記及診斷方法
CN106029898B (zh) * 2014-01-21 2020-02-28 莫尔豪斯医学院 外来体介导的感染和疾病的检测
EP3125907A4 (en) 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US11268085B2 (en) 2014-05-27 2022-03-08 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
CA2954576C (en) 2014-07-09 2020-08-11 Daniel ENDERLE Methods for isolating microvesicles and extracting nucleic acids from biological samples
ES2825708T3 (es) 2014-07-17 2021-05-17 Univ Pennsylvania Métodos para usar exosomas para monitorizar el estado de órgano trasplantado
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
WO2016077537A1 (en) 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
EP3112474A1 (en) 2015-06-29 2017-01-04 Evonik Degussa GmbH Method of detecting avian necrotic enteritis
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
CA2988585A1 (en) 2015-06-10 2016-12-15 Raghu Kalluri Use of exosomes for the treatment of disease
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
WO2017040520A1 (en) 2015-08-31 2017-03-09 Hitachi Chemical Co., Ltd. Molecular methods for assessing urothelial disease
EP3165926A1 (en) 2015-11-06 2017-05-10 Humanitas Mirasole S.p.A. Method for characterization of cell specific microvesicles
US11702702B2 (en) 2016-04-15 2023-07-18 Predicine, Inc. Systems and methods for detecting genetic alterations
KR20190020649A (ko) 2016-04-15 2019-03-04 엑소좀 디아그노스틱스, 인크. 역형성 림프종 키나아제(alk) 핵산 및 alk 융합 전사물의 혈장 기반 검출 및 암의 진단 및 치료에 있어 이의 용도
KR102741603B1 (ko) 2016-05-02 2024-12-16 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
US11214833B2 (en) 2016-05-05 2022-01-04 Exosome Diagnostics, Inc. Profiling microvesicle nucleic acids and uses thereof as signatures in diagnosis of renal transplant rejection
WO2017197399A1 (en) 2016-05-13 2017-11-16 Exosome Diagnostics, Inc. Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free dna from biofluids
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
EP3515453A1 (en) 2016-09-22 2019-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
CN110191962A (zh) 2016-10-21 2019-08-30 外来体诊断公司 外来体相关核酸的测序和分析
AU2017366813B2 (en) 2016-11-30 2023-04-20 Exosome Diagnostics, Inc. Methods and compositions to detect mutations in plasma using exosomal RNA and cell free DNA from non-small cell lung cancer patients
GB2559319B (en) 2016-12-23 2019-01-16 Cs Genetics Ltd Reagents and methods for the analysis of linked nucleic acids
WO2018126278A2 (en) 2017-01-02 2018-07-05 Exosome Diagnostics, Inc. Methods to distinguish rna and dna in a combined preparation
DK3622082T3 (da) 2017-05-12 2023-06-12 Evonik Operations Gmbh Fremgangsmåde til påvisning af c. perfringens-inducerede sygdomme i en fugleflok
CN110945145B (zh) 2017-05-17 2024-06-11 外来体诊断公司 微泡核酸和/或蛋白及其作为肾移植排斥的标志物的应用
EP3652315A4 (en) * 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHODS FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLE POPULATIONS DERIVED FROM BIOFLUIDS, AND ASSOCIATED METHODS OF USE
EP3655531B1 (en) 2017-07-18 2024-09-04 Exosome Diagnostics, Inc. Sequencing of nucleic acids associated with exosomal isolation from patients with glioblastoma multiforme
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
WO2019094578A1 (en) 2017-11-09 2019-05-16 Alnylam Pharmaceuticals Inc. Assays and methods for determining expression of the lect2 gene
CA3092472A1 (en) 2018-03-02 2019-09-06 Evonik Operations Gmbh In vitro method for detecting intestinal barrier failure in animals
US12378608B2 (en) 2018-06-06 2025-08-05 Exosome Diagnostics, Inc. Methods for developing urine biomarkers and for detecting bladder cancer
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
ES2938227T3 (es) 2018-12-14 2023-04-05 Evonik Operations Gmbh Método in vitro de detección de disbiosis intestinal aviar
EP3963070A4 (en) 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
WO2021055770A2 (en) * 2019-09-18 2021-03-25 Exosome Diagnostics, Inc. Compositions, methods, and kits for the isolation of extracellular vesicles
AU2021255132A1 (en) 2020-04-13 2022-12-08 Exoprother Medical Ltd. Cell-derived vesicles comprising wild-type P53 protein for antiviral therapy
US20210322483A1 (en) 2020-04-16 2021-10-21 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
IL277743A (en) 2020-10-01 2022-04-01 Yeda Res & Dev A method for diagnosing breast cancer
TW202214851A (zh) * 2020-10-07 2022-04-16 國立中央大學 外泌體核酸萃取方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
WO1991015574A1 (en) 1990-04-03 1991-10-17 Southwest Foundation For Biomedical Research Purified hcv and hcv proteins and peptides
GB9416671D0 (en) 1994-08-17 1994-10-12 Biocine Spa Assay
EP0841945B1 (en) * 1995-08-03 2006-03-08 Rijksuniversiteit te Leiden Cell derived antigen presenting vesicles
GB9517926D0 (en) 1995-09-01 1995-11-01 Biocine Spa Binding protein
FR2766205B1 (fr) * 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
DE69841322D1 (de) * 1997-10-06 2010-01-07 Novartis Vaccines & Diagnostic Hepatitis c rezeptorprotein cd81
DE69836758T2 (de) * 1997-11-06 2007-10-11 Innogenetics N.V. Apo b, annexin v und tubulin: medizinische und diagnostische verwendung und verwendung zur purifikation von hcv
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110123838A (zh) * 2018-02-02 2019-08-16 上海睿泰生物科技股份有限公司 负载白藜芦醇的人多能干细胞外泌体及其制备方法与用途
CN110123841A (zh) * 2018-02-09 2019-08-16 上海市第六人民医院 负载白藜芦醇的人多能干细胞外泌体在制备治疗生殖系统疾病药物的用途

Also Published As

Publication number Publication date
AU1721801A (en) 2001-05-30
EP1230347B1 (en) 2007-09-12
DE60036403T2 (de) 2008-06-12
US7807438B2 (en) 2010-10-05
CA2392075C (en) 2011-01-04
JP4675017B2 (ja) 2011-04-20
DE60036403D1 (de) 2007-10-25
DK1230347T3 (da) 2007-11-05
JP2003514523A (ja) 2003-04-22
ATE373084T1 (de) 2007-09-15
US7198923B1 (en) 2007-04-03
EP1230347A1 (en) 2002-08-14
WO2001036601A1 (en) 2001-05-25
CY1107521T1 (el) 2013-03-13
ES2292489T3 (es) 2008-03-16
CA2392075A1 (en) 2001-05-25
PT1230347E (pt) 2007-12-20
US20070254351A1 (en) 2007-11-01

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