ATE508119T1 - Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer - Google Patents
Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmerInfo
- Publication number
- ATE508119T1 ATE508119T1 AT07812739T AT07812739T ATE508119T1 AT E508119 T1 ATE508119 T1 AT E508119T1 AT 07812739 T AT07812739 T AT 07812739T AT 07812739 T AT07812739 T AT 07812739T AT E508119 T1 ATE508119 T1 AT E508119T1
- Authority
- AT
- Austria
- Prior art keywords
- bipyrimidinyl
- protein kinase
- kinase inhibitors
- diamine derivatives
- diamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83049206P | 2006-07-12 | 2006-07-12 | |
PCT/US2007/073111 WO2008008747A1 (en) | 2006-07-12 | 2007-07-10 | [4,5']bipyrimidinyl-6,4'-diamine derivatives as protein kinase inhbitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE508119T1 true ATE508119T1 (de) | 2011-05-15 |
Family
ID=38617203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07812739T ATE508119T1 (de) | 2006-07-12 | 2007-07-10 | Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer |
Country Status (21)
Country | Link |
---|---|
US (1) | US8026243B2 (pl) |
EP (1) | EP2044036B1 (pl) |
JP (1) | JP2009543798A (pl) |
KR (1) | KR20090029832A (pl) |
CN (1) | CN101511798B (pl) |
AR (1) | AR061867A1 (pl) |
AT (1) | ATE508119T1 (pl) |
AU (1) | AU2007272646A1 (pl) |
BR (1) | BRPI0714291A2 (pl) |
CA (1) | CA2657381A1 (pl) |
CL (1) | CL2007002017A1 (pl) |
DE (1) | DE602007014374D1 (pl) |
ES (1) | ES2367666T3 (pl) |
MX (1) | MX2009000429A (pl) |
PE (1) | PE20080548A1 (pl) |
PL (1) | PL2044036T3 (pl) |
PT (1) | PT2044036E (pl) |
RU (1) | RU2009104340A (pl) |
TW (1) | TW200811134A (pl) |
UY (1) | UY30477A1 (pl) |
WO (1) | WO2008008747A1 (pl) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
EP2516423A1 (en) | 2009-12-21 | 2012-10-31 | Bayer CropScience AG | Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
WO2012175513A1 (en) | 2011-06-20 | 2012-12-27 | Bayer Intellectual Property Gmbh | Thienylpyri(mi)dinylpyrazole |
UA114410C2 (uk) | 2011-10-06 | 2017-06-12 | Байєр Інтеллектуал Проперті Гмбх | Гетероциклілпіри(mi)динілпіразол |
JP6042896B2 (ja) | 2011-10-06 | 2016-12-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 殺菌剤としての複素環ピリ(ミ)ジニルピラゾール |
LT2841428T (lt) | 2012-04-24 | 2018-12-10 | Vertex Pharmaceuticals Incorporated | Dnr-pk inhibitoriai |
RS55908B1 (sr) | 2012-06-13 | 2017-09-29 | Incyte Holdings Corp | Substituisana triciklična jedinjenja kao inhibitori fgfr |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
EA031631B1 (ru) * | 2012-09-27 | 2019-01-31 | Чугаи Сеияку Кабушики Каиша | Способ лечения или предупреждения злокачественного новообразования, способ отбора пациента, способ тестирования предрасположенности к злокачественному новообразованию у субъекта, гибридный полипептид и его применения |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
DK2970218T3 (en) | 2013-03-12 | 2019-03-25 | Vertex Pharma | DNA-PK inhibitors |
MX367878B (es) | 2013-04-19 | 2019-09-10 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
EP3424920B1 (en) | 2013-10-17 | 2020-04-15 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
BR112017002268B1 (pt) | 2014-08-18 | 2022-11-08 | Eisai R&D Management Co., Ltd | Sal de derivado de piridina monocíclica e cristal do mesmo |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
ES2751669T3 (es) | 2015-02-20 | 2020-04-01 | Incyte Corp | Heterociclos bicíclicos como inhibidores FGFR |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
AU2017335648B2 (en) | 2016-09-27 | 2022-02-17 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
KR102613433B1 (ko) * | 2017-10-11 | 2023-12-13 | 주식회사 대웅제약 | 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물 |
MX2020008610A (es) | 2018-03-28 | 2020-09-21 | Eisai R&D Man Co Ltd | Agente terapeutico para carcinoma hepatocelular. |
AU2019262195B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
KR102133595B1 (ko) | 2019-05-31 | 2020-07-13 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
KR102112336B1 (ko) | 2019-08-12 | 2020-05-18 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
CN115835908A (zh) | 2019-10-14 | 2023-03-21 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
US11407750B2 (en) | 2019-12-04 | 2022-08-09 | Incyte Corporation | Derivatives of an FGFR inhibitor |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CA3215903A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
MXPA05012281A (es) | 2003-05-14 | 2006-05-19 | Torreypines Therapeutics Inc | Compuestos y uso de los mismos en la modulacion beta amiloide. |
US7189729B2 (en) * | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
EP1751136B1 (en) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
US20090069327A1 (en) | 2006-02-06 | 2009-03-12 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
-
2007
- 2007-07-04 TW TW096124311A patent/TW200811134A/zh unknown
- 2007-07-10 EP EP07812739A patent/EP2044036B1/en not_active Not-in-force
- 2007-07-10 BR BRPI0714291-9A2A patent/BRPI0714291A2/pt not_active Application Discontinuation
- 2007-07-10 KR KR1020097002815A patent/KR20090029832A/ko not_active Application Discontinuation
- 2007-07-10 RU RU2009104340/04A patent/RU2009104340A/ru not_active Application Discontinuation
- 2007-07-10 MX MX2009000429A patent/MX2009000429A/es not_active Application Discontinuation
- 2007-07-10 CN CN2007800337140A patent/CN101511798B/zh not_active Expired - Fee Related
- 2007-07-10 AT AT07812739T patent/ATE508119T1/de active
- 2007-07-10 JP JP2009519623A patent/JP2009543798A/ja active Pending
- 2007-07-10 PL PL07812739T patent/PL2044036T3/pl unknown
- 2007-07-10 WO PCT/US2007/073111 patent/WO2008008747A1/en active Application Filing
- 2007-07-10 ES ES07812739T patent/ES2367666T3/es active Active
- 2007-07-10 PT PT07812739T patent/PT2044036E/pt unknown
- 2007-07-10 AR ARP070103061A patent/AR061867A1/es unknown
- 2007-07-10 AU AU2007272646A patent/AU2007272646A1/en not_active Abandoned
- 2007-07-10 DE DE602007014374T patent/DE602007014374D1/de active Active
- 2007-07-10 US US12/373,441 patent/US8026243B2/en not_active Expired - Fee Related
- 2007-07-10 PE PE2007000885A patent/PE20080548A1/es not_active Application Discontinuation
- 2007-07-10 CA CA002657381A patent/CA2657381A1/en not_active Abandoned
- 2007-07-11 UY UY30477A patent/UY30477A1/es not_active Application Discontinuation
- 2007-07-11 CL CL200702017A patent/CL2007002017A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20100234376A1 (en) | 2010-09-16 |
AR061867A1 (es) | 2008-09-24 |
AU2007272646A1 (en) | 2008-01-17 |
CN101511798B (zh) | 2011-11-02 |
WO2008008747A1 (en) | 2008-01-17 |
EP2044036A1 (en) | 2009-04-08 |
DE602007014374D1 (de) | 2011-06-16 |
TW200811134A (en) | 2008-03-01 |
PE20080548A1 (es) | 2008-06-24 |
KR20090029832A (ko) | 2009-03-23 |
RU2009104340A (ru) | 2010-08-20 |
EP2044036B1 (en) | 2011-05-04 |
JP2009543798A (ja) | 2009-12-10 |
BRPI0714291A2 (pt) | 2014-10-21 |
CA2657381A1 (en) | 2008-01-17 |
MX2009000429A (es) | 2009-01-29 |
PL2044036T3 (pl) | 2011-09-30 |
CN101511798A (zh) | 2009-08-19 |
UY30477A1 (es) | 2009-04-30 |
ES2367666T3 (es) | 2011-11-07 |
CL2007002017A1 (es) | 2008-06-13 |
US8026243B2 (en) | 2011-09-27 |
PT2044036E (pt) | 2011-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE508119T1 (de) | Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer | |
ATE518860T1 (de) | Pyrroloä2,3-büpyridinderivate als proteinkinaseinhibitoren | |
ATE520671T1 (de) | Pyrimidin-harnstoff-derivate als kinase-hemmer | |
ATE492544T1 (de) | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer | |
DE602005020465D1 (de) | Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer | |
DE602007008837D1 (de) | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine | |
LTC2091918I2 (lt) | Junginiai ir kompozicijos, kaip proteinkinazės inhibitoriai | |
ATE400271T1 (de) | Aryl-pyridinderivate als 11-beta-hsd1-hemmer | |
ATE420076T1 (de) | Indozolonderivate als 11b-hsd1-inhibitoren | |
DE602004025258D1 (de) | Aminotriazol-verbindungen als proteinkinase-hemmer | |
ATE524467T1 (de) | Neuartige aza-heterozyklen als kinase-inhibitoren | |
ATE404564T1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
ATE452631T1 (de) | N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer | |
ATE490254T1 (de) | Imidazoä1,2-aüpyridin-verbindungen als vegf-r2- hemmer | |
DE602006015607D1 (de) | Thiazol-4-carboxamid-derivate als mglur5-antagonisten | |
ATE452891T1 (de) | Pyrimidopyrimidone als kinaseinhibitoren | |
DE602004012154D1 (de) | Pyridoä2,3-düpyrimidin-2,4-diamine als pde-2-inhibitoren | |
ATE509011T1 (de) | Pyrimidinderivate als 11beta-hsd1-inhibitoren | |
DE602006019624D1 (de) | Piperidin-4-yl-pyridazin-3-yl-aminderivate als schnell dissoziierende antagonisten des dopamin-2-rezeptors | |
ATE452132T1 (de) | Benzimidazolthiophenverbindungen als plk- inhibitoren | |
ATE396724T1 (de) | 1h-thieno 2,3-c-pyrazol-derivate als kinase-i- hemmer | |
DE602004026905D1 (de) | 2-aminoaryloxazol-verbindungen als tyrosinkinase-hemmer | |
ATE472532T1 (de) | Oxindole als kinaseinhibitoren | |
ATE435865T1 (de) | Als pde5-inhibitoren verwendete pyrazoloä4,3- düpyrimidin-5-ylderivate | |
ATE521603T1 (de) | Chinazolinderivate als tyrosinkinaseinhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 2044036 Country of ref document: EP |