ATE502933T1 - Amidsubstituierte indazole als poly-(adp-ribose)- polymerase (parp)-hemmer - Google Patents
Amidsubstituierte indazole als poly-(adp-ribose)- polymerase (parp)-hemmerInfo
- Publication number
- ATE502933T1 ATE502933T1 AT08702101T AT08702101T ATE502933T1 AT E502933 T1 ATE502933 T1 AT E502933T1 AT 08702101 T AT08702101 T AT 08702101T AT 08702101 T AT08702101 T AT 08702101T AT E502933 T1 ATE502933 T1 AT E502933T1
- Authority
- AT
- Austria
- Prior art keywords
- parp
- adp
- ribose
- polymerase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700432.8A GB0700432D0 (en) | 2007-01-10 | 2007-01-10 | Therapeutic compounds |
| US92131007P | 2007-04-02 | 2007-04-02 | |
| PCT/GB2008/050018 WO2008084261A1 (en) | 2007-01-10 | 2008-01-08 | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502933T1 true ATE502933T1 (de) | 2011-04-15 |
Family
ID=37809722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08702101T ATE502933T1 (de) | 2007-01-10 | 2008-01-08 | Amidsubstituierte indazole als poly-(adp-ribose)- polymerase (parp)-hemmer |
Country Status (21)
| Country | Link |
|---|---|
| CN (1) | CN101578279B (da) |
| AT (1) | ATE502933T1 (da) |
| CR (1) | CR10910A (da) |
| DE (1) | DE602008005711D1 (da) |
| DK (2) | DK2336120T3 (da) |
| ES (3) | ES2362214T3 (da) |
| GB (1) | GB0700432D0 (da) |
| HN (1) | HN2009001260A (da) |
| HU (1) | HUE044513T2 (da) |
| LT (1) | LT2805945T (da) |
| LU (1) | LUC00072I2 (da) |
| ME (1) | ME03481B (da) |
| MY (1) | MY147789A (da) |
| NI (1) | NI200900135A (da) |
| NZ (1) | NZ578256A (da) |
| PE (1) | PE20081558A1 (da) |
| PT (3) | PT2805945T (da) |
| SI (2) | SI2109608T1 (da) |
| TW (1) | TWI528961B (da) |
| UA (1) | UA97658C2 (da) |
| ZA (1) | ZA200903898B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106496187A (zh) * | 2016-09-14 | 2017-03-15 | 陕西科技大学 | 一种制备PARP抑制剂Niraparib的合成方法 |
| CN106432188A (zh) * | 2016-09-17 | 2017-02-22 | 青岛辰达生物科技有限公司 | 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法 |
| CN106432187A (zh) * | 2016-09-17 | 2017-02-22 | 青岛云天生物技术有限公司 | 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法 |
| CN106467513A (zh) * | 2016-09-30 | 2017-03-01 | 陕西科技大学 | 一种制备Niraparib的合成方法 |
| CN106632244A (zh) * | 2016-09-30 | 2017-05-10 | 陕西科技大学 | 一种制备抗癌药物Niraparib的新型合成方法 |
| CN108201537A (zh) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | 一种尼拉帕尼缓控释药物组合物及其用途 |
| WO2018183349A1 (en) * | 2017-03-27 | 2018-10-04 | Tesaro, Inc. | Niraparib formulations |
| CN109081828B (zh) | 2017-06-14 | 2021-03-26 | 上海时莱生物技术有限公司 | 聚(adp-核糖)聚合酶抑制剂、制备方法及用途 |
| MA50657A (fr) | 2017-09-26 | 2020-08-05 | Tesaro Inc | Formulations de niraparib |
| CN108084157A (zh) * | 2018-02-12 | 2018-05-29 | 安庆奇创药业有限公司 | 一种尼拉帕尼的合成方法 |
| CN108203404A (zh) * | 2018-03-02 | 2018-06-26 | 上海博邦医药科技有限公司 | (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法 |
| EP4112049A1 (en) | 2020-02-24 | 2023-01-04 | Fukang (Shanghai) Health Technology Co., Ltd. | Anti-coronavirus application of poly adp ribose polymerase inhibitor |
| CN115611860B (zh) * | 2021-07-13 | 2024-06-11 | 上海博璞诺科技发展有限公司 | 合成尼拉帕尼的方法 |
-
2007
- 2007-01-10 GB GBGB0700432.8A patent/GB0700432D0/en not_active Ceased
-
2008
- 2008-01-08 AT AT08702101T patent/ATE502933T1/de active
- 2008-01-08 DE DE602008005711T patent/DE602008005711D1/de active Active
- 2008-01-08 PT PT14176452T patent/PT2805945T/pt unknown
- 2008-01-08 ES ES08702101T patent/ES2362214T3/es active Active
- 2008-01-08 SI SI200830240T patent/SI2109608T1/sl unknown
- 2008-01-08 PT PT08702101T patent/PT2109608E/pt unknown
- 2008-01-08 LT LTEP14176452.2T patent/LT2805945T/lt unknown
- 2008-01-08 MY MYPI20092876A patent/MY147789A/en unknown
- 2008-01-08 ME MEP-2019-147A patent/ME03481B/me unknown
- 2008-01-08 TW TW097100730A patent/TWI528961B/zh active
- 2008-01-08 ES ES14176452T patent/ES2728199T3/es active Active
- 2008-01-08 DK DK11157369.7T patent/DK2336120T3/da active
- 2008-01-08 SI SI200831266T patent/SI2336120T1/sl unknown
- 2008-01-08 CN CN2008800019265A patent/CN101578279B/zh active Active
- 2008-01-08 NZ NZ578256A patent/NZ578256A/en unknown
- 2008-01-08 UA UAA200908335A patent/UA97658C2/ru unknown
- 2008-01-08 ES ES11157369.7T patent/ES2509115T3/es active Active
- 2008-01-08 PE PE2008000097A patent/PE20081558A1/es active IP Right Grant
- 2008-01-08 DK DK08702101.0T patent/DK2109608T3/da active
- 2008-01-08 PT PT111573697T patent/PT2336120E/pt unknown
- 2008-01-08 HU HUE14176452 patent/HUE044513T2/hu unknown
-
2009
- 2009-06-04 ZA ZA200903898A patent/ZA200903898B/xx unknown
- 2009-07-02 CR CR10910A patent/CR10910A/es unknown
- 2009-07-02 HN HN2009001260A patent/HN2009001260A/es unknown
- 2009-07-02 NI NI200900135A patent/NI200900135A/es unknown
-
2018
- 2018-05-03 LU LU00072C patent/LUC00072I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LUC00072I2 (fr) | 2018-07-04 |
| HUE044513T2 (hu) | 2019-10-28 |
| DK2336120T3 (da) | 2014-10-06 |
| CN101578279B (zh) | 2013-07-17 |
| NZ578256A (en) | 2011-12-22 |
| PE20081558A1 (es) | 2008-10-30 |
| ME03481B (me) | 2020-01-20 |
| UA97658C2 (ru) | 2012-03-12 |
| HN2009001260A (es) | 2012-03-26 |
| ZA200903898B (en) | 2010-04-28 |
| ES2509115T3 (es) | 2014-10-17 |
| ES2728199T3 (es) | 2019-10-22 |
| ES2362214T3 (es) | 2011-06-29 |
| TWI528961B (zh) | 2016-04-11 |
| LT2805945T (lt) | 2019-06-25 |
| MY147789A (en) | 2013-01-31 |
| TW200836731A (en) | 2008-09-16 |
| DE602008005711D1 (de) | 2011-05-05 |
| SI2109608T1 (sl) | 2011-07-29 |
| CN101578279A (zh) | 2009-11-11 |
| PT2109608E (pt) | 2011-05-30 |
| NI200900135A (es) | 2010-08-30 |
| DK2109608T3 (da) | 2011-07-11 |
| CR10910A (es) | 2010-01-19 |
| PT2336120E (pt) | 2014-10-01 |
| PT2805945T (pt) | 2019-06-06 |
| SI2336120T1 (sl) | 2014-10-30 |
| GB0700432D0 (en) | 2007-02-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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