DK2336120T3 - Kombinationer, der indeholder amid-substituerede indazoler som poly(adp-ribose)polymerase (parp)-hæmmere - Google Patents

Kombinationer, der indeholder amid-substituerede indazoler som poly(adp-ribose)polymerase (parp)-hæmmere

Info

Publication number
DK2336120T3
DK2336120T3 DK11157369.7T DK11157369T DK2336120T3 DK 2336120 T3 DK2336120 T3 DK 2336120T3 DK 11157369 T DK11157369 T DK 11157369T DK 2336120 T3 DK2336120 T3 DK 2336120T3
Authority
DK
Denmark
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
DK11157369.7T
Other languages
English (en)
Inventor
Ontoria Jesus Maria Ontoria
Rita Scarpeli
Carsten Schultz-Fademrecht
Philip Jones
Original Assignee
Msd Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2336120(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Italia Srl filed Critical Msd Italia Srl
Priority claimed from EP08702101A external-priority patent/EP2109608B1/en
Application granted granted Critical
Publication of DK2336120T3 publication Critical patent/DK2336120T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK11157369.7T 2007-01-10 2008-01-08 Kombinationer, der indeholder amid-substituerede indazoler som poly(adp-ribose)polymerase (parp)-hæmmere DK2336120T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02
EP08702101A EP2109608B1 (en) 2007-01-10 2008-01-08 Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors

Publications (1)

Publication Number Publication Date
DK2336120T3 true DK2336120T3 (da) 2014-10-06

Family

ID=37809722

Family Applications (2)

Application Number Title Priority Date Filing Date
DK08702101.0T DK2109608T3 (da) 2007-01-10 2008-01-08 Amid-substituerede indazoler som poly(ADP-ribose)polymerase- (PARP) hæmmere
DK11157369.7T DK2336120T3 (da) 2007-01-10 2008-01-08 Kombinationer, der indeholder amid-substituerede indazoler som poly(adp-ribose)polymerase (parp)-hæmmere

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08702101.0T DK2109608T3 (da) 2007-01-10 2008-01-08 Amid-substituerede indazoler som poly(ADP-ribose)polymerase- (PARP) hæmmere

Country Status (21)

Country Link
CN (1) CN101578279B (da)
AT (1) ATE502933T1 (da)
CR (1) CR10910A (da)
DE (1) DE602008005711D1 (da)
DK (2) DK2109608T3 (da)
ES (3) ES2362214T3 (da)
GB (1) GB0700432D0 (da)
HN (1) HN2009001260A (da)
HU (1) HUE044513T2 (da)
LT (1) LT2805945T (da)
LU (1) LUC00072I2 (da)
ME (1) ME03481B (da)
MY (1) MY147789A (da)
NI (1) NI200900135A (da)
NZ (1) NZ578256A (da)
PE (1) PE20081558A1 (da)
PT (3) PT2336120E (da)
SI (2) SI2109608T1 (da)
TW (1) TWI528961B (da)
UA (1) UA97658C2 (da)
ZA (1) ZA200903898B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
JP2020512347A (ja) * 2017-03-27 2020-04-23 テサロ， インコーポレイテッド ニラパリブ製剤
CN109081828B (zh) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CN111278433A (zh) 2017-09-26 2020-06-12 特沙诺有限公司 尼拉帕尼制剂
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
WO2021169984A1 (zh) 2020-02-24 2021-09-02 甫康（上海）健康科技有限责任公司 聚adp核糖聚合酶抑制剂在抗冠状病毒中的应用
CN115611860A (zh) * 2021-07-13 2023-01-17 上海博璞诺科技发展有限公司 合成尼拉帕尼的方法

Also Published As

Publication number Publication date
NZ578256A (en) 2011-12-22
LUC00072I2 (fr) 2018-07-04
LT2805945T (lt) 2019-06-25
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
ES2362214T3 (es) 2011-06-29
PE20081558A1 (es) 2008-10-30
HN2009001260A (es) 2012-03-26
TW200836731A (en) 2008-09-16
CN101578279A (zh) 2009-11-11
CN101578279B (zh) 2013-07-17
GB0700432D0 (en) 2007-02-21
MY147789A (en) 2013-01-31
SI2109608T1 (sl) 2011-07-29
PT2109608E (pt) 2011-05-30
ES2509115T3 (es) 2014-10-17
ATE502933T1 (de) 2011-04-15
ZA200903898B (en) 2010-04-28
NI200900135A (es) 2010-08-30
TWI528961B (zh) 2016-04-11
CR10910A (es) 2010-01-19
DE602008005711D1 (de) 2011-05-05
ME03481B (me) 2020-01-20
UA97658C2 (ru) 2012-03-12
ES2728199T3 (es) 2019-10-22
DK2109608T3 (da) 2011-07-11
HUE044513T2 (hu) 2019-10-28
PT2336120E (pt) 2014-10-01

Similar Documents

Publication Publication Date Title
DK2336120T3 (da) Kombinationer, der indeholder amid-substituerede indazoler som poly(adp-ribose)polymerase (parp)-hæmmere
MX2009007200A (es) Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
MX2010005070A (es) Derivados de piridazinona como inhibidores de parp.
WO2007138351A3 (en) Pyridinone and pyridazinone derivatives as inhibitors of poly(adp-ribose)polymerase (parp)
CR20110077A (es) Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol
EA201190158A1 (ru) Производные бензофуранила для применения в качестве ингибиторов глюкокиназы
WO2008103277A3 (en) Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
MX2012002179A (es) Compuestos heterociclicos de oxima.
BR112015002293A2 (pt) di-hidropiridona pi como inibidores do fator xia
EA201100503A1 (ru) Глюкозидные производные и их применения
MX2013001204A (es) Compuesto para el tratamiento/prevencion de enfermedades inflamatorias oculares.
WO2008017883A3 (en) 4-oxo-4,5-dihydropyrrolo[1,2-a] quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
MX2012007582A (es) Compuestos de 4-fenoxi-nicotinamida o 4-fenoxi-pirimidina-5-carbox amida.
WO2011147951A8 (en) Cycloamino derivatives as gpr119 agonists
MA32322B1 (fr) Dérivés d'urée macrocyclique et de sulfamide en tant qu'inhibiteurs de tafia
MX2011013869A (es) Agentes antihelminticos y su uso.
PH12015500418A1 (en) Pyridine derivative and medicine
GB201114389D0 (en) Novel compounds
TH105541B (th) อินดาโซลถูกแทนที่เอไมด์ในรูปสารยับยั้งโพลี(adp-ไรโบส)โพลีเมอเรส(parp)
TR201901937T4 (tr) 8-metil-1-fenil-imidazol[1,5-a]pirazin bileşikleri.