DE602008005711D1 - Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer - Google Patents

Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer

Info

Publication number
DE602008005711D1
DE602008005711D1 DE602008005711T DE602008005711T DE602008005711D1 DE 602008005711 D1 DE602008005711 D1 DE 602008005711D1 DE 602008005711 T DE602008005711 T DE 602008005711T DE 602008005711 T DE602008005711 T DE 602008005711T DE 602008005711 D1 DE602008005711 D1 DE 602008005711D1
Authority
DE
Germany
Prior art keywords
parp
adp
ribose
polymerase
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008005711T
Other languages
English (en)
Inventor
Philip Jones
Ontoria Jesus Maria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Original Assignee
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602008005711(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto di Ricerche di Biologia Molecolare P Angeletti SpA filed Critical Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Priority claimed from PCT/GB2008/050018 external-priority patent/WO2008084261A1/en
Publication of DE602008005711D1 publication Critical patent/DE602008005711D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602008005711T 2007-01-10 2008-01-08 Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer Active DE602008005711D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02
PCT/GB2008/050018 WO2008084261A1 (en) 2007-01-10 2008-01-08 Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors

Publications (1)

Publication Number Publication Date
DE602008005711D1 true DE602008005711D1 (de) 2011-05-05

Family

ID=37809722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008005711T Active DE602008005711D1 (de) 2007-01-10 2008-01-08 Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer

Country Status (21)

Country Link
CN (1) CN101578279B (de)
AT (1) ATE502933T1 (de)
CR (1) CR10910A (de)
DE (1) DE602008005711D1 (de)
DK (2) DK2109608T3 (de)
ES (3) ES2362214T3 (de)
GB (1) GB0700432D0 (de)
HN (1) HN2009001260A (de)
HU (1) HUE044513T2 (de)
LT (1) LT2805945T (de)
LU (1) LUC00072I2 (de)
ME (1) ME03481B (de)
MY (1) MY147789A (de)
NI (1) NI200900135A (de)
NZ (1) NZ578256A (de)
PE (1) PE20081558A1 (de)
PT (3) PT2805945T (de)
SI (2) SI2109608T1 (de)
TW (1) TWI528961B (de)
UA (1) UA97658C2 (de)
ZA (1) ZA200903898B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
EA201992162A1 (ru) * 2017-03-27 2020-02-28 Тесаро, Инк. Составы на основе нирапариба
CN109081828B (zh) 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CN111278433A (zh) 2017-09-26 2020-06-12 特沙诺有限公司 尼拉帕尼制剂
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
WO2021169984A1 (zh) 2020-02-24 2021-09-02 甫康（上海）健康科技有限责任公司 聚adp核糖聚合酶抑制剂在抗冠状病毒中的应用
CN115611860B (zh) * 2021-07-13 2024-06-11 上海博璞诺科技发展有限公司 合成尼拉帕尼的方法

Also Published As

Publication number Publication date
HUE044513T2 (hu) 2019-10-28
SI2109608T1 (sl) 2011-07-29
LT2805945T (lt) 2019-06-25
MY147789A (en) 2013-01-31
GB0700432D0 (en) 2007-02-21
ES2362214T3 (es) 2011-06-29
CN101578279B (zh) 2013-07-17
PT2336120E (pt) 2014-10-01
DK2109608T3 (da) 2011-07-11
PE20081558A1 (es) 2008-10-30
ES2728199T3 (es) 2019-10-22
TWI528961B (zh) 2016-04-11
NI200900135A (es) 2010-08-30
NZ578256A (en) 2011-12-22
ES2509115T3 (es) 2014-10-17
ME03481B (de) 2020-01-20
UA97658C2 (ru) 2012-03-12
DK2336120T3 (da) 2014-10-06
PT2109608E (pt) 2011-05-30
CR10910A (es) 2010-01-19
CN101578279A (zh) 2009-11-11
ATE502933T1 (de) 2011-04-15
TW200836731A (en) 2008-09-16
ZA200903898B (en) 2010-04-28
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
HN2009001260A (es) 2012-03-26
LUC00072I2 (fr) 2018-07-04

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