PT2109608E - Indazoles amida-substitu?dos como inibidores de poli(adpribose) polimerase (parp) - Google Patents

Indazoles amida-substitu?dos como inibidores de poli(adpribose) polimerase (parp) Download PDF

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Publication number
PT2109608E
PT2109608E PT08702101T PT08702101T PT2109608E PT 2109608 E PT2109608 E PT 2109608E PT 08702101 T PT08702101 T PT 08702101T PT 08702101 T PT08702101 T PT 08702101T PT 2109608 E PT2109608 E PT 2109608E
Authority
PT
Portugal
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
PT08702101T
Other languages
English (en)
Inventor
Rita Scarpelli
Philip Jones
Jesus Maria Ontoria Ontoria
Carsten Schultz-Fademrecht
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2109608(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of PT2109608E publication Critical patent/PT2109608E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT08702101T 2007-01-10 2008-01-08 Indazoles amida-substitu?dos como inibidores de poli(adpribose) polimerase (parp) PT2109608E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02

Publications (1)

Publication Number Publication Date
PT2109608E true PT2109608E (pt) 2011-05-30

Family

ID=37809722

Family Applications (3)

Application Number Title Priority Date Filing Date
PT08702101T PT2109608E (pt) 2007-01-10 2008-01-08 Indazoles amida-substitu?dos como inibidores de poli(adpribose) polimerase (parp)
PT111573697T PT2336120E (pt) 2007-01-10 2008-01-08 Combinações contendo indazoles amida-substituídos como inibidores de poli(adp-ribose) polimerase (parp)
PT14176452T PT2805945T (pt) 2007-01-10 2008-01-08 Indazoles amida- substituídos como inibidores de poli ( adpribose) polimerase (parp)

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT111573697T PT2336120E (pt) 2007-01-10 2008-01-08 Combinações contendo indazoles amida-substituídos como inibidores de poli(adp-ribose) polimerase (parp)
PT14176452T PT2805945T (pt) 2007-01-10 2008-01-08 Indazoles amida- substituídos como inibidores de poli ( adpribose) polimerase (parp)

Country Status (21)

Country Link
CN (1) CN101578279B (pt)
AT (1) ATE502933T1 (pt)
CR (1) CR10910A (pt)
DE (1) DE602008005711D1 (pt)
DK (2) DK2336120T3 (pt)
ES (3) ES2728199T3 (pt)
GB (1) GB0700432D0 (pt)
HN (1) HN2009001260A (pt)
HU (1) HUE044513T2 (pt)
LT (1) LT2805945T (pt)
LU (1) LUC00072I2 (pt)
ME (1) ME03481B (pt)
MY (1) MY147789A (pt)
NI (1) NI200900135A (pt)
NZ (1) NZ578256A (pt)
PE (1) PE20081558A1 (pt)
PT (3) PT2109608E (pt)
SI (2) SI2109608T1 (pt)
TW (1) TWI528961B (pt)
UA (1) UA97658C2 (pt)
ZA (1) ZA200903898B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
KR20190130625A (ko) * 2017-03-27 2019-11-22 테사로, 인코포레이티드 니라파립 제제
CN109081828B (zh) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CA3076907A1 (en) 2017-09-26 2019-04-04 Tesaro, Inc. Niraparib formulations
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
US20240016775A1 (en) 2020-02-24 2024-01-18 Fukang (Shanghai) Health Technology Co., Ltd Anti-coronavirus application of poly adp ribose polymerase inhibitor
CN115611860B (zh) * 2021-07-13 2024-06-11 上海博璞诺科技发展有限公司 合成尼拉帕尼的方法

Also Published As

Publication number Publication date
LT2805945T (lt) 2019-06-25
TW200836731A (en) 2008-09-16
ATE502933T1 (de) 2011-04-15
NZ578256A (en) 2011-12-22
GB0700432D0 (en) 2007-02-21
CN101578279A (zh) 2009-11-11
SI2109608T1 (sl) 2011-07-29
DE602008005711D1 (de) 2011-05-05
LUC00072I2 (fr) 2018-07-04
MY147789A (en) 2013-01-31
CR10910A (es) 2010-01-19
HUE044513T2 (hu) 2019-10-28
ES2509115T3 (es) 2014-10-17
ME03481B (me) 2020-01-20
UA97658C2 (ru) 2012-03-12
ZA200903898B (en) 2010-04-28
PT2336120E (pt) 2014-10-01
DK2109608T3 (da) 2011-07-11
HN2009001260A (es) 2012-03-26
PE20081558A1 (es) 2008-10-30
ES2728199T3 (es) 2019-10-22
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
NI200900135A (es) 2010-08-30
ES2362214T3 (es) 2011-06-29
DK2336120T3 (da) 2014-10-06
TWI528961B (zh) 2016-04-11
CN101578279B (zh) 2013-07-17

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