NZ578256A - Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors - Google Patents
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitorsInfo
- Publication number
- NZ578256A NZ578256A NZ578256A NZ57825608A NZ578256A NZ 578256 A NZ578256 A NZ 578256A NZ 578256 A NZ578256 A NZ 578256A NZ 57825608 A NZ57825608 A NZ 57825608A NZ 578256 A NZ578256 A NZ 578256A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- indazole
- piperidin
- pharmaceutically acceptable
- carboxamide
- Prior art date
Links
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- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 title claims abstract description 41
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- PCHKPVIQAHNQLW-AWEZNQCLSA-N 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@H]1CCCNC1 PCHKPVIQAHNQLW-AWEZNQCLSA-N 0.000 claims 1
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- NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
- 229960000922 vinflunine Drugs 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229940053890 zanosar Drugs 0.000 description 1
- 229940072168 zocor Drugs 0.000 description 1
- 229940061261 zolinza Drugs 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- 229950005752 zosuquidar Drugs 0.000 description 1
- IHOVFYSQUDPMCN-QKUIIBHLSA-N zosuquidar Chemical compound C([C@H](COC=1C2=CC=CN=C2C=CC=1)O)N(CC1)CCN1C1C2=CC=CC=C2C2C(F)(F)C2C2=CC=CC=C12 IHOVFYSQUDPMCN-QKUIIBHLSA-N 0.000 description 1
- 229940088909 zyloprim Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0700432.8A GB0700432D0 (en) | 2007-01-10 | 2007-01-10 | Therapeutic compounds |
US92131007P | 2007-04-02 | 2007-04-02 | |
PCT/GB2008/050018 WO2008084261A1 (en) | 2007-01-10 | 2008-01-08 | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ578256A true NZ578256A (en) | 2011-12-22 |
Family
ID=37809722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ578256A NZ578256A (en) | 2007-01-10 | 2008-01-08 | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
Country Status (21)
Country | Link |
---|---|
CN (1) | CN101578279B (en) |
AT (1) | ATE502933T1 (en) |
CR (1) | CR10910A (en) |
DE (1) | DE602008005711D1 (en) |
DK (2) | DK2336120T3 (en) |
ES (3) | ES2509115T3 (en) |
GB (1) | GB0700432D0 (en) |
HN (1) | HN2009001260A (en) |
HU (1) | HUE044513T2 (en) |
LT (1) | LT2805945T (en) |
LU (1) | LUC00072I2 (en) |
ME (1) | ME03481B (en) |
MY (1) | MY147789A (en) |
NI (1) | NI200900135A (en) |
NZ (1) | NZ578256A (en) |
PE (1) | PE20081558A1 (en) |
PT (3) | PT2336120E (en) |
SI (2) | SI2109608T1 (en) |
TW (1) | TWI528961B (en) |
UA (1) | UA97658C2 (en) |
ZA (1) | ZA200903898B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106496187A (en) * | 2016-09-14 | 2017-03-15 | 陕西科技大学 | A kind of synthetic method for preparing PARP inhibitor Niraparib |
CN106432187A (en) * | 2016-09-17 | 2017-02-22 | 青岛云天生物技术有限公司 | Chiral resolution method of 2-[4-(-3-piperidyl)phenyl]-2H-indazole-7-formamide |
CN106432188A (en) * | 2016-09-17 | 2017-02-22 | 青岛辰达生物科技有限公司 | Preparation method of anti-cancer drug 2-[4-((3S)-3-Piperidinyl) phenyl]-2H-Indazole-7-Formamide |
CN106467513A (en) * | 2016-09-30 | 2017-03-01 | 陕西科技大学 | A kind of synthetic method preparing Niraparib |
CN106632244A (en) * | 2016-09-30 | 2017-05-10 | 陕西科技大学 | A novel synthetic method for preparing an anticancer medicine Niraparib |
CN108201537A (en) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof |
EA201992162A1 (en) * | 2017-03-27 | 2020-02-28 | Тесаро, Инк. | COMPOSITIONS BASED ON NIRAPARIB |
CN109081828B (en) * | 2017-06-14 | 2021-03-26 | 上海时莱生物技术有限公司 | Poly (ADP-ribose) polymerase inhibitor, preparation method and application |
EA202090573A1 (en) | 2017-09-26 | 2020-09-07 | Тесаро, Инк. | COMPOSITIONS OF NIRAPARIBA |
CN108084157A (en) * | 2018-02-12 | 2018-05-29 | 安庆奇创药业有限公司 | A kind of synthetic method of Ni Lapani |
CN108203404A (en) * | 2018-03-02 | 2018-06-26 | 上海博邦医药科技有限公司 | (R) synthetic method of -3- Phenylpiperidines or/and the chiral intermediate of (S) -3- Phenylpiperidines and Ni Lapani |
US20240016775A1 (en) | 2020-02-24 | 2024-01-18 | Fukang (Shanghai) Health Technology Co., Ltd | Anti-coronavirus application of poly adp ribose polymerase inhibitor |
CN115611860B (en) * | 2021-07-13 | 2024-06-11 | 上海博璞诺科技发展有限公司 | Method for synthesizing nilaparib |
-
2007
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2008
- 2008-01-08 LT LTEP14176452.2T patent/LT2805945T/en unknown
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- 2008-01-08 ES ES11157369.7T patent/ES2509115T3/en active Active
- 2008-01-08 PT PT111573697T patent/PT2336120E/en unknown
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- 2008-01-08 DK DK08702101.0T patent/DK2109608T3/en active
- 2008-01-08 PE PE2008000097A patent/PE20081558A1/en active IP Right Grant
- 2008-01-08 PT PT14176452T patent/PT2805945T/en unknown
- 2008-01-08 CN CN2008800019265A patent/CN101578279B/en active Active
- 2008-01-08 ES ES14176452T patent/ES2728199T3/en active Active
- 2008-01-08 PT PT08702101T patent/PT2109608E/en unknown
- 2008-01-08 UA UAA200908335A patent/UA97658C2/en unknown
- 2008-01-08 DE DE602008005711T patent/DE602008005711D1/en active Active
- 2008-01-08 NZ NZ578256A patent/NZ578256A/en unknown
- 2008-01-08 SI SI200831266T patent/SI2336120T1/en unknown
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2009
- 2009-06-04 ZA ZA200903898A patent/ZA200903898B/en unknown
- 2009-07-02 HN HN2009001260A patent/HN2009001260A/en unknown
- 2009-07-02 NI NI200900135A patent/NI200900135A/en unknown
- 2009-07-02 CR CR10910A patent/CR10910A/en unknown
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2018
- 2018-05-03 LU LU00072C patent/LUC00072I2/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200836731A (en) | 2008-09-16 |
CR10910A (en) | 2010-01-19 |
ZA200903898B (en) | 2010-04-28 |
CN101578279A (en) | 2009-11-11 |
GB0700432D0 (en) | 2007-02-21 |
DK2109608T3 (en) | 2011-07-11 |
PE20081558A1 (en) | 2008-10-30 |
ATE502933T1 (en) | 2011-04-15 |
SI2109608T1 (en) | 2011-07-29 |
PT2336120E (en) | 2014-10-01 |
LT2805945T (en) | 2019-06-25 |
HN2009001260A (en) | 2012-03-26 |
PT2109608E (en) | 2011-05-30 |
TWI528961B (en) | 2016-04-11 |
PT2805945T (en) | 2019-06-06 |
SI2336120T1 (en) | 2014-10-30 |
LUC00072I2 (en) | 2018-07-04 |
MY147789A (en) | 2013-01-31 |
ES2362214T3 (en) | 2011-06-29 |
NI200900135A (en) | 2010-08-30 |
CN101578279B (en) | 2013-07-17 |
HUE044513T2 (en) | 2019-10-28 |
DE602008005711D1 (en) | 2011-05-05 |
DK2336120T3 (en) | 2014-10-06 |
ES2509115T3 (en) | 2014-10-17 |
ES2728199T3 (en) | 2019-10-22 |
ME03481B (en) | 2020-01-20 |
UA97658C2 (en) | 2012-03-12 |
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