LT2805945T - Amidu pakeistieji indazolai, kaip poli(adp-ribozės)polimerazės (parp) inhibitoriai - Google Patents

Amidu pakeistieji indazolai, kaip poli(adp-ribozės)polimerazės (parp) inhibitoriai

Info

Publication number
LT2805945T
LT2805945T LTEP14176452.2T LT14176452T LT2805945T LT 2805945 T LT2805945 T LT 2805945T LT 14176452 T LT14176452 T LT 14176452T LT 2805945 T LT2805945 T LT 2805945T
Authority
LT
Lithuania
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
LTEP14176452.2T
Other languages
English (en)
Inventor
Jesus Maria Ontoria Ontoria
Rita Scarpeli
Carsten Schultz-Fademrecht
Philip Jones
Original Assignee
Msd Italia S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2805945(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Italia S.R.L. filed Critical Msd Italia S.R.L.
Publication of LT2805945T publication Critical patent/LT2805945T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTEP14176452.2T 2007-01-10 2008-01-08 Amidu pakeistieji indazolai, kaip poli(adp-ribozės)polimerazės (parp) inhibitoriai LT2805945T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US92131007P 2007-04-02 2007-04-02

Publications (1)

Publication Number Publication Date
LT2805945T true LT2805945T (lt) 2019-06-25

Family

ID=37809722

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14176452.2T LT2805945T (lt) 2007-01-10 2008-01-08 Amidu pakeistieji indazolai, kaip poli(adp-ribozės)polimerazės (parp) inhibitoriai

Country Status (21)

Country Link
CN (1) CN101578279B (lt)
AT (1) ATE502933T1 (lt)
CR (1) CR10910A (lt)
DE (1) DE602008005711D1 (lt)
DK (2) DK2109608T3 (lt)
ES (3) ES2509115T3 (lt)
GB (1) GB0700432D0 (lt)
HN (1) HN2009001260A (lt)
HU (1) HUE044513T2 (lt)
LT (1) LT2805945T (lt)
LU (1) LUC00072I2 (lt)
ME (1) ME03481B (lt)
MY (1) MY147789A (lt)
NI (1) NI200900135A (lt)
NZ (1) NZ578256A (lt)
PE (1) PE20081558A1 (lt)
PT (3) PT2805945T (lt)
SI (2) SI2336120T1 (lt)
TW (1) TWI528961B (lt)
UA (1) UA97658C2 (lt)
ZA (1) ZA200903898B (lt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
CA3058372A1 (en) * 2017-03-27 2018-10-04 Tesaro, Inc. Niraparib formulations
CN109081828B (zh) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CA3076907A1 (en) 2017-09-26 2019-04-04 Tesaro, Inc. Niraparib formulations
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
JP2023514794A (ja) 2020-02-24 2023-04-10 フーカン（シャンハイ） ヘルス テクノロジー カンパニー、 リミテッド ポリａｄｐリボースポリメラーゼ阻害剤の抗コロナウイルス応用

Also Published As

Publication number Publication date
ATE502933T1 (de) 2011-04-15
ES2728199T3 (es) 2019-10-22
GB0700432D0 (en) 2007-02-21
CN101578279B (zh) 2013-07-17
PT2336120E (pt) 2014-10-01
ME03481B (me) 2020-01-20
UA97658C2 (ru) 2012-03-12
NZ578256A (en) 2011-12-22
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
DK2109608T3 (da) 2011-07-11
CR10910A (es) 2010-01-19
NI200900135A (es) 2010-08-30
HN2009001260A (es) 2012-03-26
PE20081558A1 (es) 2008-10-30
MY147789A (en) 2013-01-31
DK2336120T3 (da) 2014-10-06
LUC00072I2 (fr) 2018-07-04
SI2109608T1 (sl) 2011-07-29
ZA200903898B (en) 2010-04-28
TW200836731A (en) 2008-09-16
HUE044513T2 (hu) 2019-10-28
PT2109608E (pt) 2011-05-30
CN101578279A (zh) 2009-11-11
ES2509115T3 (es) 2014-10-17
TWI528961B (zh) 2016-04-11
ES2362214T3 (es) 2011-06-29
DE602008005711D1 (de) 2011-05-05

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