ES2362214T3 - Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). - Google Patents

Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). Download PDF

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Publication number
ES2362214T3
ES2362214T3 ES08702101T ES08702101T ES2362214T3 ES 2362214 T3 ES2362214 T3 ES 2362214T3 ES 08702101 T ES08702101 T ES 08702101T ES 08702101 T ES08702101 T ES 08702101T ES 2362214 T3 ES2362214 T3 ES 2362214T3
Authority
ES
Spain
Prior art keywords
compound
pharmaceutically acceptable
indazol
cancer
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08702101T
Other languages
English (en)
Spanish (es)
Inventor
Philip Jones
Jesus Maria Ontoria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Original Assignee
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2362214(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto di Ricerche di Biologia Molecolare P Angeletti SpA filed Critical Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Application granted granted Critical
Publication of ES2362214T3 publication Critical patent/ES2362214T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES08702101T 2007-01-10 2008-01-08 Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). Active ES2362214T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0700432 2007-01-10
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
US921310P 2007-04-02

Publications (1)

Publication Number Publication Date
ES2362214T3 true ES2362214T3 (es) 2011-06-29

Family

ID=37809722

Family Applications (3)

Application Number Title Priority Date Filing Date
ES11157369.7T Active ES2509115T3 (es) 2007-01-10 2008-01-08 Combinaciones que contienen indazoles sustituidos con amida como inhibidores de poli(ADP-ribosa) polimerasa (PARP)
ES14176452T Active ES2728199T3 (es) 2007-01-10 2008-01-08 Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP)
ES08702101T Active ES2362214T3 (es) 2007-01-10 2008-01-08 Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES11157369.7T Active ES2509115T3 (es) 2007-01-10 2008-01-08 Combinaciones que contienen indazoles sustituidos con amida como inhibidores de poli(ADP-ribosa) polimerasa (PARP)
ES14176452T Active ES2728199T3 (es) 2007-01-10 2008-01-08 Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP)

Country Status (21)

Country Link
CN (1) CN101578279B (da)
AT (1) ATE502933T1 (da)
CR (1) CR10910A (da)
DE (1) DE602008005711D1 (da)
DK (2) DK2109608T3 (da)
ES (3) ES2509115T3 (da)
GB (1) GB0700432D0 (da)
HN (1) HN2009001260A (da)
HU (1) HUE044513T2 (da)
LT (1) LT2805945T (da)
LU (1) LUC00072I2 (da)
ME (1) ME03481B (da)
MY (1) MY147789A (da)
NI (1) NI200900135A (da)
NZ (1) NZ578256A (da)
PE (1) PE20081558A1 (da)
PT (3) PT2805945T (da)
SI (2) SI2336120T1 (da)
TW (1) TWI528961B (da)
UA (1) UA97658C2 (da)
ZA (1) ZA200903898B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法
CN106432188A (zh) * 2016-09-17 2017-02-22 青岛辰达生物科技有限公司 一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106432187A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106632244A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种制备抗癌药物Niraparib的新型合成方法
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
CN108201537A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种尼拉帕尼缓控释药物组合物及其用途
CA3058372A1 (en) * 2017-03-27 2018-10-04 Tesaro, Inc. Niraparib formulations
CN109081828B (zh) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 聚(adp-核糖)聚合酶抑制剂、制备方法及用途
CA3076907A1 (en) 2017-09-26 2019-04-04 Tesaro, Inc. Niraparib formulations
CN108084157A (zh) * 2018-02-12 2018-05-29 安庆奇创药业有限公司 一种尼拉帕尼的合成方法
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
JP2023514794A (ja) 2020-02-24 2023-04-10 フーカン（シャンハイ） ヘルス テクノロジー カンパニー、 リミテッド ポリａｄｐリボースポリメラーゼ阻害剤の抗コロナウイルス応用

Also Published As

Publication number Publication date
ATE502933T1 (de) 2011-04-15
ES2728199T3 (es) 2019-10-22
GB0700432D0 (en) 2007-02-21
CN101578279B (zh) 2013-07-17
PT2336120E (pt) 2014-10-01
ME03481B (me) 2020-01-20
UA97658C2 (ru) 2012-03-12
NZ578256A (en) 2011-12-22
PT2805945T (pt) 2019-06-06
SI2336120T1 (sl) 2014-10-30
DK2109608T3 (da) 2011-07-11
CR10910A (es) 2010-01-19
LT2805945T (lt) 2019-06-25
NI200900135A (es) 2010-08-30
HN2009001260A (es) 2012-03-26
PE20081558A1 (es) 2008-10-30
MY147789A (en) 2013-01-31
DK2336120T3 (da) 2014-10-06
LUC00072I2 (fr) 2018-07-04
SI2109608T1 (sl) 2011-07-29
ZA200903898B (en) 2010-04-28
TW200836731A (en) 2008-09-16
HUE044513T2 (hu) 2019-10-28
PT2109608E (pt) 2011-05-30
CN101578279A (zh) 2009-11-11
ES2509115T3 (es) 2014-10-17
TWI528961B (zh) 2016-04-11
DE602008005711D1 (de) 2011-05-05

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