ATE500345T1 - Kunitz-domäne-bibliothek - Google Patents
Kunitz-domäne-bibliothekInfo
- Publication number
- ATE500345T1 ATE500345T1 AT04700617T AT04700617T ATE500345T1 AT E500345 T1 ATE500345 T1 AT E500345T1 AT 04700617 T AT04700617 T AT 04700617T AT 04700617 T AT04700617 T AT 04700617T AT E500345 T1 ATE500345 T1 AT E500345T1
- Authority
- AT
- Austria
- Prior art keywords
- kunitz domain
- domain library
- libraries
- kunitz
- phage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Gyroscopes (AREA)
- Optical Communication System (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43849103P | 2003-01-07 | 2003-01-07 | |
| PCT/US2004/000333 WO2004063337A2 (en) | 2003-01-07 | 2004-01-07 | Kunitz domain library |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500345T1 true ATE500345T1 (de) | 2011-03-15 |
Family
ID=32713336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04700617T ATE500345T1 (de) | 2003-01-07 | 2004-01-07 | Kunitz-domäne-bibliothek |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040209243A1 (enExample) |
| EP (2) | EP1587907B1 (enExample) |
| JP (2) | JP2007524348A (enExample) |
| AT (1) | ATE500345T1 (enExample) |
| AU (1) | AU2004204095B2 (enExample) |
| CA (1) | CA2512590A1 (enExample) |
| DE (1) | DE602004031589D1 (enExample) |
| DK (1) | DK1587907T3 (enExample) |
| ES (1) | ES2362424T3 (enExample) |
| PT (1) | PT1587907E (enExample) |
| WO (1) | WO2004063337A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4137997B2 (ja) * | 1994-01-11 | 2008-08-20 | ダイアックス コープ. | クニッツドメインから誘導されたヒトプラスミンの阻害剤 |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| EP1531791B1 (en) * | 2002-06-07 | 2010-08-11 | Dyax Corp. | Prevention and reduction of ischemia |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| AU2005309722B2 (en) * | 2004-11-22 | 2011-10-20 | Dyax Corp. | Plasmin-inhibitory therapies |
| TW200745159A (en) * | 2005-07-13 | 2007-12-16 | Avidia Inc | IL-6 binding proteins |
| EP2195010A4 (en) * | 2007-08-21 | 2012-03-14 | Genzyme Corp | TREATMENT WITH INHIBITORS OF KALLIKREINE |
| KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Tfpi 억제제 및 사용 방법 |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
| KR102107695B1 (ko) | 2011-01-06 | 2020-05-07 | 다이액스 코포레이션 | 혈장 칼리크레인 결합 단백질 |
| AU2013235741C1 (en) | 2012-03-21 | 2017-12-21 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| CA2881431C (en) | 2012-08-08 | 2021-10-19 | Daiichi Sankyo Company, Limited | Peptide library and use thereof |
| IL247942B (en) | 2014-03-27 | 2022-09-01 | Dyax Corp | Compositions and methods for drops in macular edema as a result of diabetes |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| SG11201700672YA (en) | 2014-08-05 | 2017-02-27 | MabQuest SA | Immunological reagents binding to pd-1 |
| KR102582035B1 (ko) | 2014-12-24 | 2023-09-22 | 넥스이뮨, 인크. | 면역요법을 위한 나노입자 조성물 및 방법 |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| EP3377080B1 (en) | 2015-11-19 | 2024-02-14 | Asclepix Therapeutics, LLC | Peptides with anti-angiogenic, anti-lymphangiogenic, and anti-edemic properties and nanoparticle formulations |
| CA2994447A1 (en) | 2015-12-11 | 2017-06-15 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| US10294299B2 (en) | 2016-01-22 | 2019-05-21 | MabQuest SA | Immunological reagents |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| ES2877568T3 (es) | 2016-02-05 | 2021-11-17 | Orionis Biosciences Nv | Agentes de unión de Clec9A |
| CN109069573B (zh) | 2016-03-07 | 2022-04-05 | 弗拉芒区生物技术研究所 | 结合cd20的单结构域抗体 |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| EP3454887B1 (en) | 2016-05-13 | 2021-01-20 | Orionis Biosciences BV | Targeted mutant interferon-beta and uses thereof |
| EP3522906B1 (en) | 2016-10-04 | 2022-03-23 | Asclepix Therapeutics, Inc. | Compounds and methods for activating tie2 signaling |
| ES2917000T3 (es) | 2016-10-24 | 2022-07-06 | Orionis Biosciences BV | Interferón-gamma mutante diana y usos del mismo |
| CN110573172A (zh) | 2017-02-06 | 2019-12-13 | 奥里尼斯生物科学有限公司 | 靶向的工程化干扰素及其用途 |
| KR102642385B1 (ko) | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
| CA3050601A1 (en) | 2017-02-07 | 2018-08-16 | Vib Vzm | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| US11674959B2 (en) | 2017-08-03 | 2023-06-13 | The Johns Hopkins University | Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors |
| US12059476B2 (en) | 2017-10-10 | 2024-08-13 | The Johns Hopkins University | Biodegradable biomimetic particles |
| WO2019094648A1 (en) | 2017-11-08 | 2019-05-16 | L.E.A.F. Holdings Group Llc | Platinum complexes and uses thereof |
| IL274677B2 (en) | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| US20200354424A1 (en) | 2018-01-26 | 2020-11-12 | Orionis Biosciences, Inc. | Xcr1 binding agents and uses thereof |
| EP3749295A4 (en) | 2018-02-05 | 2022-04-27 | Orionis Biosciences, Inc. | FIBROBLAST BINDING AGENTS AND USES THEREOF |
| US12410225B2 (en) | 2018-11-08 | 2025-09-09 | Orionis Biosciences, Inc | Modulation of dendritic cell lineages |
| CA3129834A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Claudin 6 antibodies and uses thereof |
| WO2020168024A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| CN114555127A (zh) | 2019-08-06 | 2022-05-27 | L.E.A.F.控股集团公司 | 制备聚谷氨酸化抗叶酸剂的方法以及它们的组合物的用途 |
| GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
| MX2023004280A (es) | 2020-10-14 | 2023-06-23 | Viridian Therapeutics Inc | Composiciones y metodos para el tratamiento de la enfermedad ocular tiroidea. |
| JP2024512590A (ja) | 2021-03-26 | 2024-03-19 | アーセルクス インコーポレイテッド | 多機能免疫細胞療法 |
| US20230084477A1 (en) | 2021-08-10 | 2023-03-16 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
| US20250304677A1 (en) | 2022-07-04 | 2025-10-02 | Vib Vzw | Blood-Cerebrospinal Fluid Barrier Crossing Antibodies |
| EP4598635A2 (en) | 2022-10-06 | 2025-08-13 | Bicara Therapeutics Inc. | Multispecific proteins and related methods |
| WO2024118771A1 (en) | 2022-11-30 | 2024-06-06 | Integral Molecular, Inc. | Antibodies directed to claudin 6, including bispecific formats thereof |
| WO2024208816A1 (en) | 2023-04-03 | 2024-10-10 | Vib Vzw | Blood-brain barrier crossing antibodies |
| TW202509078A (zh) | 2023-07-07 | 2025-03-01 | 美商維里迪恩醫療股份有限公司 | 治療慢性甲狀腺眼病之方法 |
| WO2025024334A1 (en) | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
| WO2025093683A1 (en) | 2023-11-03 | 2025-05-08 | Neuvasq Biotechnologies Sa | Wnt7 signaling agonists |
| WO2025136985A1 (en) | 2023-12-17 | 2025-06-26 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
| WO2025151492A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Compositions and methods for treatment of thyroid eye disease |
| WO2025151502A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Modified antibodies |
| WO2025151496A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Compositions and methods for treatment of thyroid eye disease |
| WO2025160334A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| US20250353881A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
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-
2004
- 2004-01-07 WO PCT/US2004/000333 patent/WO2004063337A2/en not_active Ceased
- 2004-01-07 US US10/753,544 patent/US20040209243A1/en not_active Abandoned
- 2004-01-07 DE DE602004031589T patent/DE602004031589D1/de not_active Expired - Lifetime
- 2004-01-07 CA CA002512590A patent/CA2512590A1/en not_active Abandoned
- 2004-01-07 ES ES04700617T patent/ES2362424T3/es not_active Expired - Lifetime
- 2004-01-07 JP JP2006500832A patent/JP2007524348A/ja active Pending
- 2004-01-07 EP EP04700617A patent/EP1587907B1/en not_active Expired - Lifetime
- 2004-01-07 DK DK04700617.6T patent/DK1587907T3/da active
- 2004-01-07 AU AU2004204095A patent/AU2004204095B2/en not_active Ceased
- 2004-01-07 AT AT04700617T patent/ATE500345T1/de active
- 2004-01-07 EP EP10012620A patent/EP2290107A1/en not_active Withdrawn
- 2004-01-07 PT PT04700617T patent/PT1587907E/pt unknown
-
2007
- 2007-07-09 US US11/774,964 patent/US20080020394A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036225A patent/JP2010162030A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004204095B2 (en) | 2009-07-30 |
| WO2004063337A2 (en) | 2004-07-29 |
| EP1587907A4 (en) | 2007-11-14 |
| DE602004031589D1 (de) | 2011-04-14 |
| JP2010162030A (ja) | 2010-07-29 |
| PT1587907E (pt) | 2011-04-08 |
| JP2007524348A (ja) | 2007-08-30 |
| US20080020394A1 (en) | 2008-01-24 |
| ES2362424T3 (es) | 2011-07-05 |
| EP1587907A2 (en) | 2005-10-26 |
| CA2512590A1 (en) | 2004-07-29 |
| AU2004204095A1 (en) | 2004-07-29 |
| DK1587907T3 (da) | 2011-04-04 |
| US20040209243A1 (en) | 2004-10-21 |
| EP1587907B1 (en) | 2011-03-02 |
| EP2290107A1 (en) | 2011-03-02 |
| WO2004063337A3 (en) | 2007-01-25 |
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