ES2362424T3 - Biblioteca del dominio kunitz. - Google Patents
Biblioteca del dominio kunitz. Download PDFInfo
- Publication number
- ES2362424T3 ES2362424T3 ES04700617T ES04700617T ES2362424T3 ES 2362424 T3 ES2362424 T3 ES 2362424T3 ES 04700617 T ES04700617 T ES 04700617T ES 04700617 T ES04700617 T ES 04700617T ES 2362424 T3 ES2362424 T3 ES 2362424T3
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- Prior art keywords
- phage
- library
- protein
- kunitz domain
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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Applications Claiming Priority (2)
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|---|---|---|---|
| US43849103P | 2003-01-07 | 2003-01-07 | |
| US438491P | 2003-01-07 |
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| ES2362424T3 true ES2362424T3 (es) | 2011-07-05 |
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| EP (2) | EP1587907B1 (enExample) |
| JP (2) | JP2007524348A (enExample) |
| AT (1) | ATE500345T1 (enExample) |
| AU (1) | AU2004204095B2 (enExample) |
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| DK (1) | DK1587907T3 (enExample) |
| ES (1) | ES2362424T3 (enExample) |
| PT (1) | PT1587907E (enExample) |
| WO (1) | WO2004063337A2 (enExample) |
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| PT737207E (pt) * | 1994-01-11 | 2005-02-28 | Dyax Corp | Inibidores de plasmina humana derivados de dominios kunitz |
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| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US7064107B2 (en) | 2002-06-07 | 2006-06-20 | Dyax Corp. | Prevention and reduction of blood loss |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP2008520729A (ja) * | 2004-11-22 | 2008-06-19 | ダイアックス コーポレーション | プラスミン阻害療法 |
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| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| NZ593815A (en) | 2008-12-19 | 2013-05-31 | Tissue factor pathway inhibitor (tfpi) inhibitors and methods of use | |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| AU2011204349C1 (en) | 2010-01-06 | 2017-02-16 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| NZ623576A (en) | 2010-03-19 | 2015-11-27 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
| WO2012094587A1 (en) | 2011-01-06 | 2012-07-12 | Dyax Corp. | Plasma kallikrein binding proteins |
| WO2013141965A1 (en) | 2012-03-21 | 2013-09-26 | Baxter International Inc. | Tfpi inhibitors and methods of use |
| ES2813867T3 (es) * | 2012-08-08 | 2021-03-25 | Daiichi Sankyo Co Ltd | Biblioteca de péptidos y su uso |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| AU2015298356B2 (en) | 2014-08-05 | 2020-11-19 | MabQuest SA | Immunological reagents binding to pd-1 |
| MX391015B (es) | 2014-12-24 | 2025-03-21 | Neximmune Inc | Composiciones de nanoparticulas y usos de las mismas |
| WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| KR20180081608A (ko) | 2015-11-19 | 2018-07-16 | 아스클리픽스 테라퓨틱스, 엘엘씨. | 항-혈관형성, 항-림프관신생, 및 항-부종성 특성을 가진 펩티드 및 나노입자 제제 |
| IL311156A (en) | 2015-12-11 | 2024-04-01 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| FI3964529T3 (fi) | 2016-01-22 | 2025-06-13 | MabQuest SA | Ei-estäviä PD1-spesifisiä vasta-aineita |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| CA3013558C (en) | 2016-02-05 | 2024-11-12 | Universiteit Gent | CD8 LIAISON OFFICERS |
| WO2017153402A1 (en) | 2016-03-07 | 2017-09-14 | Vib Vzw | Cd20 binding single domain antibodies |
| WO2017194783A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| EP3455245A2 (en) | 2016-05-13 | 2019-03-20 | Orionis Biosciences NV | Therapeutic targeting of non-cellular structures |
| AU2017339970A1 (en) | 2016-10-04 | 2019-04-18 | Asclepix Therapeutics, Llc | Compounds and methods for activating Tie2 signaling |
| WO2018077893A1 (en) | 2016-10-24 | 2018-05-03 | Orionis Biosciences Nv | Targeted mutant interferon-gamma and uses thereof |
| KR102642385B1 (ko) | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
| CN110573172A (zh) | 2017-02-06 | 2019-12-13 | 奥里尼斯生物科学有限公司 | 靶向的工程化干扰素及其用途 |
| CA3050601A1 (en) | 2017-02-07 | 2018-08-16 | Vib Vzm | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| WO2019028427A1 (en) | 2017-08-03 | 2019-02-07 | Asclepix Therapeutics, Llc. | METHODS OF IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS TO ACTIVATE TIE2 RECEPTOR |
| US12059476B2 (en) | 2017-10-10 | 2024-08-13 | The Johns Hopkins University | Biodegradable biomimetic particles |
| EP3706801B1 (en) | 2017-11-08 | 2026-01-14 | L.E.A.F Holdings Group LLC | Platinum complexes and uses thereof |
| IL274677B2 (en) | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| WO2019148089A1 (en) | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| JP2021513361A (ja) | 2018-02-05 | 2021-05-27 | オリオニス バイオサイエンシーズ，インコーポレイテッド | 線維芽細胞結合物質およびその使用 |
| US12410225B2 (en) | 2018-11-08 | 2025-09-09 | Orionis Biosciences, Inc | Modulation of dendritic cell lineages |
| JP2022520632A (ja) | 2019-02-15 | 2022-03-31 | インテグラル・モレキュラー・インコーポレイテッド | 共通軽鎖を含む抗体及びその使用 |
| KR20210128443A (ko) | 2019-02-15 | 2021-10-26 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6 항체 및 이의 용도 |
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| GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
| CA3195512A1 (en) | 2020-10-14 | 2022-04-21 | Vahe Bedian | Compositions and methods for treatment of thyroid eye disease |
| GB202019817D0 (en) * | 2020-12-15 | 2021-01-27 | Univ Oxford Innovation Ltd | Ligand-binding polypeptides and uses thereof |
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| TW202320850A (zh) | 2021-08-10 | 2023-06-01 | 美商維里迪恩醫療股份有限公司 | 用於治療甲狀腺眼病之組合物、劑量及方法 |
| US20250304677A1 (en) | 2022-07-04 | 2025-10-02 | Vib Vzw | Blood-Cerebrospinal Fluid Barrier Crossing Antibodies |
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| KR20250114330A (ko) | 2022-11-30 | 2025-07-29 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6을 표적하는 항체 및 이의 이중특이적 형식 |
| WO2024208816A1 (en) | 2023-04-03 | 2024-10-10 | Vib Vzw | Blood-brain barrier crossing antibodies |
| TW202509078A (zh) | 2023-07-07 | 2025-03-01 | 美商維里迪恩醫療股份有限公司 | 治療慢性甲狀腺眼病之方法 |
| WO2025024334A1 (en) | 2023-07-21 | 2025-01-30 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
| WO2025093683A1 (en) | 2023-11-03 | 2025-05-08 | Neuvasq Biotechnologies Sa | Wnt7 signaling agonists |
| WO2025136985A1 (en) | 2023-12-17 | 2025-06-26 | Viridian Therapeutics, Inc. | Compositions, doses, and methods for treatment of thyroid eye disease |
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| WO2025151502A1 (en) | 2024-01-09 | 2025-07-17 | Viridian Therapeutics, Inc. | Modified antibodies |
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| WO2025160334A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| US20250353881A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
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2004
- 2004-01-07 DE DE602004031589T patent/DE602004031589D1/de not_active Expired - Lifetime
- 2004-01-07 EP EP04700617A patent/EP1587907B1/en not_active Expired - Lifetime
- 2004-01-07 ES ES04700617T patent/ES2362424T3/es not_active Expired - Lifetime
- 2004-01-07 WO PCT/US2004/000333 patent/WO2004063337A2/en not_active Ceased
- 2004-01-07 DK DK04700617.6T patent/DK1587907T3/da active
- 2004-01-07 AU AU2004204095A patent/AU2004204095B2/en not_active Ceased
- 2004-01-07 EP EP10012620A patent/EP2290107A1/en not_active Withdrawn
- 2004-01-07 AT AT04700617T patent/ATE500345T1/de active
- 2004-01-07 JP JP2006500832A patent/JP2007524348A/ja active Pending
- 2004-01-07 US US10/753,544 patent/US20040209243A1/en not_active Abandoned
- 2004-01-07 PT PT04700617T patent/PT1587907E/pt unknown
- 2004-01-07 CA CA002512590A patent/CA2512590A1/en not_active Abandoned
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2007
- 2007-07-09 US US11/774,964 patent/US20080020394A1/en not_active Abandoned
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2010
- 2010-02-22 JP JP2010036225A patent/JP2010162030A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1587907A4 (en) | 2007-11-14 |
| PT1587907E (pt) | 2011-04-08 |
| WO2004063337A3 (en) | 2007-01-25 |
| AU2004204095A1 (en) | 2004-07-29 |
| US20080020394A1 (en) | 2008-01-24 |
| CA2512590A1 (en) | 2004-07-29 |
| AU2004204095B2 (en) | 2009-07-30 |
| ATE500345T1 (de) | 2011-03-15 |
| WO2004063337A2 (en) | 2004-07-29 |
| EP1587907A2 (en) | 2005-10-26 |
| EP2290107A1 (en) | 2011-03-02 |
| JP2010162030A (ja) | 2010-07-29 |
| DK1587907T3 (da) | 2011-04-04 |
| JP2007524348A (ja) | 2007-08-30 |
| US20040209243A1 (en) | 2004-10-21 |
| DE602004031589D1 (de) | 2011-04-14 |
| EP1587907B1 (en) | 2011-03-02 |
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