ATE488579T1 - Rna-nachweisenzyme - Google Patents
Rna-nachweisenzymeInfo
- Publication number
- ATE488579T1 ATE488579T1 AT03743221T AT03743221T ATE488579T1 AT E488579 T1 ATE488579 T1 AT E488579T1 AT 03743221 T AT03743221 T AT 03743221T AT 03743221 T AT03743221 T AT 03743221T AT E488579 T1 ATE488579 T1 AT E488579T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid sequences
- zymes
- cleavage
- rna detection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L9/00—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols
- H04L9/40—Network security protocols
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L65/00—Network arrangements, protocols or services for supporting real-time applications in data packet communication
- H04L65/1066—Session management
- H04L65/1101—Session protocols
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L69/00—Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass
- H04L69/30—Definitions, standards or architectural aspects of layered protocol stacks
- H04L69/32—Architecture of open systems interconnection [OSI] 7-layer type protocol stacks, e.g. the interfaces between the data link level and the physical level
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Computer Security & Cryptography (AREA)
- Computer Networks & Wireless Communication (AREA)
- Signal Processing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/084,839 US7150982B2 (en) | 1991-09-09 | 2002-02-26 | RNA detection assays |
PCT/US2003/005613 WO2003073067A2 (en) | 2002-02-26 | 2003-02-26 | Rna detection enzymes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE488579T1 true ATE488579T1 (de) | 2010-12-15 |
Family
ID=27765329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03743221T ATE488579T1 (de) | 2002-02-26 | 2003-02-26 | Rna-nachweisenzyme |
Country Status (11)
Country | Link |
---|---|
US (1) | US7150982B2 (de) |
EP (2) | EP1504093B1 (de) |
JP (1) | JP4363988B2 (de) |
CN (1) | CN1302104C (de) |
AT (1) | ATE488579T1 (de) |
AU (3) | AU2003216392A1 (de) |
CA (1) | CA2477698C (de) |
DE (1) | DE60334985D1 (de) |
ES (1) | ES2354874T3 (de) |
HK (1) | HK1081593A1 (de) |
WO (1) | WO2003073067A2 (de) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6759226B1 (en) * | 2000-05-24 | 2004-07-06 | Third Wave Technologies, Inc. | Enzymes for the detection of specific nucleic acid sequences |
US7118860B2 (en) * | 1999-10-29 | 2006-10-10 | Stratagene California | Methods for detection of a target nucleic acid by capture |
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
US8206904B2 (en) | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
EP1573009B1 (de) | 2002-12-18 | 2011-09-21 | Third Wave Technologies, Inc. | Nachweis kleiner nukleinsäuren |
US7700750B2 (en) * | 2003-01-09 | 2010-04-20 | Third Wave Technologies, Inc. | Connexin allele detection assays |
CA2552949C (en) * | 2004-01-07 | 2012-10-02 | Third Wave Technologies, Inc. | Determination of hepatitis c virus genotype |
US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
GB2416538B (en) * | 2004-07-26 | 2008-07-30 | Bioline Ltd | Chimeric DNA polymerase |
US7482127B2 (en) * | 2005-11-03 | 2009-01-27 | Third Wave Technologies, Inc. | Nucleic acid detection assays employing blocker oligonucleotides |
KR101105564B1 (ko) | 2006-06-01 | 2012-01-17 | 써드 웨이브 테크놀로지스, 아이앤씨. | 핵산의 검출 |
US7772390B1 (en) | 2006-07-18 | 2010-08-10 | The Regents Of The University Of California | Lipid mediated nucleic acid synthesis |
CA2665188C (en) | 2006-10-04 | 2014-08-19 | Third Wave Technologies, Inc. | Snap-back primers and detectable hairpin structures |
EP2132549B1 (de) * | 2007-03-30 | 2013-09-11 | Roche Diagnostics GmbH | Alkylamine zur verbesserten erkennung von komponenten formaldehyd-fixierter biologischer proben |
WO2009117327A2 (en) | 2008-03-15 | 2009-09-24 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reactions |
US20110136118A1 (en) * | 2008-06-17 | 2011-06-09 | Sigma-Aldrich Co. | Real time polymerase chain reaction process using a universal detection system |
WO2010026450A1 (en) * | 2008-09-03 | 2010-03-11 | Quantumdx Group Limited | Sensing strategies and methods for nucleic acid detection using biosensors |
CN102245761A (zh) | 2008-11-03 | 2011-11-16 | 卡帕生物系统 | 修饰a型dna聚合酶 |
EP2524036B1 (de) | 2009-07-31 | 2019-06-12 | Agilent Technologies, Inc. | Wärmestabile dna-polymerasemutanten vom typ a mit erhöhter polymerisationsrate und resistenz gegenüber inhibitoren |
US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
US8715937B2 (en) | 2010-11-15 | 2014-05-06 | Exact Sciences Corporation | Mutation detection assay |
US9315787B2 (en) | 2011-01-14 | 2016-04-19 | Kapa Biosystems, Inc. | Modified DNA polymerases for improved amplification |
WO2012110060A1 (en) | 2011-02-15 | 2012-08-23 | Roche Diagnostics Gmbh | Dna polymerases with increased 3'-mismatch discrimination |
NZ728024A (en) | 2012-05-25 | 2019-05-31 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
CN104271771A (zh) * | 2012-06-20 | 2015-01-07 | 东丽株式会社 | 核酸的检测方法及核酸检测试剂盒 |
WO2014089290A1 (en) | 2012-12-06 | 2014-06-12 | Sigma-Aldrich Co. Llc | Crispr-based genome modification and regulation |
EP3434776A1 (de) | 2012-12-12 | 2019-01-30 | The Broad Institute, Inc. | Verfahren, modelle, systeme und vorrichtungen zur identifikation von zielsequenzen für cas-enzyme oder crispr-cas-systeme für zielsequenzen und förderresultate davon |
DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
DK2898075T3 (en) | 2012-12-12 | 2016-06-27 | Broad Inst Inc | CONSTRUCTION AND OPTIMIZATION OF IMPROVED SYSTEMS, PROCEDURES AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION |
EP2840140B2 (de) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | CRISPR-Cas verwendetes Verfahren zur Mutation von Prokaryonten |
PL2771468T3 (pl) * | 2012-12-12 | 2015-07-31 | Broad Inst Inc | Inżynieria systemów, metod i zoptymalizowanych kompozycji kierujących dla manipulacji sekwencjami |
IL293526A (en) | 2012-12-12 | 2022-08-01 | Harvard College | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
WO2014158628A1 (en) | 2013-03-14 | 2014-10-02 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules |
EP3011031B1 (de) | 2013-06-17 | 2020-09-30 | The Broad Institute Inc. | Abgabe und verwendung von crispr-cas-systemen, vektoren und zusammensetzungen für leber-targeting und -behandlung |
AU2014281031B2 (en) | 2013-06-17 | 2020-05-21 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components |
EP3011029B1 (de) | 2013-06-17 | 2019-12-11 | The Broad Institute, Inc. | Bereitstellung, technische konzeption und optimierung von tandemführungssystemen, verfahren und zusammensetzungen zur sequenzmanipulation |
CN105492611A (zh) | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
WO2014204727A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
ES2943498T3 (es) | 2013-08-05 | 2023-06-13 | Twist Bioscience Corp | Genotecas sintetizadas de novo |
WO2015045593A1 (ja) | 2013-09-30 | 2015-04-02 | Necソリューションイノベータ株式会社 | ターゲットの分析方法および分析キット |
WO2015065964A1 (en) | 2013-10-28 | 2015-05-07 | The Broad Institute Inc. | Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof |
US9834791B2 (en) | 2013-11-07 | 2017-12-05 | Editas Medicine, Inc. | CRISPR-related methods and compositions with governing gRNAS |
AU2014348323B2 (en) * | 2013-11-14 | 2020-09-24 | Integrated Dna Technologies, Inc. | DNA polymerase mutants having enhanced template discrimination activity |
EP3080271B1 (de) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systeme, verfahren und zusammensetzungen zur sequenzmanipulation mit optimierten funktionellen crispr-cas-systemen |
WO2015089351A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
EP3079725B1 (de) | 2013-12-12 | 2019-10-16 | The Broad Institute, Inc. | Abgabe, verwendung und therapeutische anwendungen der crispr-cas-systeme und zusammensetzungen zur genomeditierung |
WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
CA2932439A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute, Inc. | Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes |
US11028388B2 (en) | 2014-03-05 | 2021-06-08 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa |
WO2015138510A1 (en) | 2014-03-10 | 2015-09-17 | Editas Medicine., Inc. | Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10) |
US11339437B2 (en) | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
WO2015148863A2 (en) | 2014-03-26 | 2015-10-01 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
EP3985115A1 (de) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Geschützte guide-rnas (pgrnas) |
DE102014225789A1 (de) | 2014-12-15 | 2016-06-16 | Henkel Ag & Co. Kgaa | Wasch- und Reinigungsmittel |
CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
KR102535217B1 (ko) | 2015-04-24 | 2023-05-19 | 에디타스 메디신, 인코포레이티드 | Cas9 분자/가이드 rna 분자 복합체의 평가 |
JP6688318B2 (ja) | 2015-05-01 | 2020-04-28 | ジェン−プローブ・インコーポレーテッド | 多重侵入切断アッセイ |
CN108290933A (zh) | 2015-06-18 | 2018-07-17 | 布罗德研究所有限公司 | 降低脱靶效应的crispr酶突变 |
WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
IL258164B (en) | 2015-09-18 | 2022-09-01 | Twist Bioscience Corp | Methods to regulate the activity of proteins and cells and a method for the production of nucleic acids |
CN113604546A (zh) | 2015-09-22 | 2021-11-05 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
EP3384077A4 (de) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | Funktionalisierte oberflächen und herstellung davon |
WO2017165862A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency |
US11566263B2 (en) | 2016-08-02 | 2023-01-31 | Editas Medicine, Inc. | Compositions and methods for treating CEP290 associated disease |
AU2017315294B2 (en) | 2016-08-22 | 2023-12-21 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
EA201991262A1 (ru) | 2016-12-16 | 2020-04-07 | Твист Байосайенс Корпорейшн | Библиотеки вариантов иммунологического синапса и их синтез |
EP3586255A4 (de) | 2017-02-22 | 2021-03-31 | Twist Bioscience Corporation | Nukleinsäurebasierte datenspeicherung |
EP3596217A1 (de) | 2017-03-14 | 2020-01-22 | Editas Medicine, Inc. | Systeme und verfahren zur behandlung von hämoglobinopathien |
EP3595674A4 (de) | 2017-03-15 | 2020-12-16 | Twist Bioscience Corporation | Variante bibliotheken der immunologischen synapse und synthese davon |
WO2018209158A2 (en) | 2017-05-10 | 2018-11-15 | Editas Medicine, Inc. | Crispr/rna-guided nuclease systems and methods |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
JP7169999B2 (ja) | 2017-06-12 | 2022-11-11 | ツイスト バイオサイエンス コーポレーション | シームレス核酸アセンブリのための方法 |
WO2019026884A1 (ja) | 2017-07-31 | 2019-02-07 | 凸版印刷株式会社 | 核酸検出方法および検出用試薬 |
EP4219766A3 (de) | 2017-08-11 | 2023-10-11 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von staphylococcus aureus |
GB2581620A (en) | 2017-09-11 | 2020-08-26 | Twist Bioscience Corp | GPCR binding proteins and synthesis thereof |
JP7066840B2 (ja) | 2017-10-20 | 2022-05-13 | ツイスト バイオサイエンス コーポレーション | ポリヌクレオチド合成のための加熱されたナノウェル |
WO2019118550A1 (en) | 2017-12-13 | 2019-06-20 | Gen-Probe Incorporated | Methods for biological sample processing |
US20200318171A1 (en) | 2017-12-15 | 2020-10-08 | Gen-Probe Incorporated | Compositions and Methods for Detecting Toxigenic Clostridium Difficile |
AU2019205269A1 (en) | 2018-01-04 | 2020-07-30 | Twist Bioscience Corporation | DNA-based digital information storage |
CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
WO2020154513A1 (en) | 2019-01-25 | 2020-07-30 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
KR20210143766A (ko) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
EP3987019A4 (de) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-basierte nukleinsäuresequenzanordnung |
CN115803434A (zh) | 2020-05-29 | 2023-03-14 | 基诺泰科有限公司 | 具有提高的对基因变异的辨别性的dna聚合酶变体 |
AU2022357542A1 (en) | 2021-09-30 | 2024-03-14 | Gen-Probe Incorporated | Temperature-selectable fret cassette signaling |
DE102021214680A1 (de) | 2021-12-20 | 2023-06-22 | Henkel Ag & Co. Kgaa | Neue Tensidkombination und Wasch- und Reinigungsmittel, welche diese enthalten |
WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466591A (en) * | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
US5795762A (en) * | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
US5244797B1 (en) * | 1988-01-13 | 1998-08-25 | Life Technologies Inc | Cloned genes encoding reverse transcriptase lacking rnase h activity |
US6037120A (en) | 1995-10-12 | 2000-03-14 | Benner; Steven Albert | Recognition of oligonucleotides containing non-standard base pairs |
US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
US6140496A (en) | 1990-10-09 | 2000-10-31 | Benner; Steven Albert | Precursors for deoxyribonucleotides containing non-standard nucleosides |
US5846717A (en) * | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
US5459055A (en) * | 1991-12-27 | 1995-10-17 | Epicentre Technologies Corporation | Thermostable ribonuclease H isolated from Thermus flavus |
US5268289A (en) * | 1991-12-27 | 1993-12-07 | Epicentre Technologies Corp. | Thermostable ribonuclease H |
US5541311A (en) * | 1992-12-07 | 1996-07-30 | Third Wave Technologies, Inc. | Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
US5614402A (en) * | 1992-12-07 | 1997-03-25 | Third Wave Technologies, Inc. | 5' nucleases derived from thermostable DNA polymerase |
US5837458A (en) * | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5874283A (en) * | 1995-05-30 | 1999-02-23 | John Joseph Harrington | Mammalian flap-specific endonuclease |
US5912340A (en) | 1995-10-04 | 1999-06-15 | Epoch Pharmaceuticals, Inc. | Selective binding complementary oligonucleotides |
EP0904286A4 (de) | 1996-01-24 | 2004-01-14 | Third Wave Tech Inc | Invasive spaltung von nukleinsäuren |
US5985557A (en) * | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
US6090606A (en) * | 1996-01-24 | 2000-07-18 | Third Wave Technologies, Inc. | Cleavage agents |
AU737449B2 (en) | 1996-11-29 | 2001-08-23 | Third Wave Technologies, Inc. | FEN-1 endonucleases, mixtures and cleavage methods |
EP1007732B1 (de) | 1997-01-17 | 2006-07-26 | Maxygen, Inc. | EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION |
US6143877A (en) | 1997-04-30 | 2000-11-07 | Epoch Pharmaceuticals, Inc. | Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids |
US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
KR20010052894A (ko) | 1998-06-17 | 2001-06-25 | 맥시겐, 인크. | 목적하는 특성을 보유한 폴리뉴클레오티드를 생성하는 방법 |
EP1117777A2 (de) | 1998-09-29 | 2001-07-25 | Maxygen, Inc. | Shuffling von gene mit veränderten kodons |
JP2004521606A (ja) * | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Rnaの検出法 |
-
2002
- 2002-02-26 US US10/084,839 patent/US7150982B2/en not_active Expired - Fee Related
-
2003
- 2003-02-26 ES ES03743221T patent/ES2354874T3/es not_active Expired - Lifetime
- 2003-02-26 WO PCT/US2003/005613 patent/WO2003073067A2/en active Application Filing
- 2003-02-26 AT AT03743221T patent/ATE488579T1/de not_active IP Right Cessation
- 2003-02-26 CN CNB038091593A patent/CN1302104C/zh not_active Expired - Lifetime
- 2003-02-26 EP EP03743221A patent/EP1504093B1/de not_active Expired - Lifetime
- 2003-02-26 JP JP2003571706A patent/JP4363988B2/ja not_active Expired - Lifetime
- 2003-02-26 AU AU2003216392A patent/AU2003216392A1/en not_active Abandoned
- 2003-02-26 DE DE60334985T patent/DE60334985D1/de not_active Expired - Lifetime
- 2003-02-26 CA CA2477698A patent/CA2477698C/en not_active Expired - Lifetime
- 2003-02-26 EP EP10178894A patent/EP2410049A1/de not_active Withdrawn
-
2006
- 2006-02-09 HK HK06101697A patent/HK1081593A1/xx not_active IP Right Cessation
-
2007
- 2007-12-21 AU AU2007254629A patent/AU2007254629B2/en not_active Expired
-
2010
- 2010-10-21 AU AU2010235947A patent/AU2010235947A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003216392A1 (en) | 2003-09-09 |
AU2007254629B2 (en) | 2010-07-22 |
EP1504093A2 (de) | 2005-02-09 |
ES2354874T3 (es) | 2011-03-18 |
EP1504093A4 (de) | 2006-08-30 |
EP1504093B1 (de) | 2010-11-17 |
HK1081593A1 (en) | 2006-05-19 |
US20030186238A1 (en) | 2003-10-02 |
CA2477698C (en) | 2011-04-26 |
AU2010235947A1 (en) | 2010-11-11 |
WO2003073067A3 (en) | 2004-11-18 |
AU2007254629A1 (en) | 2008-01-24 |
JP2005518223A (ja) | 2005-06-23 |
CN1653175A (zh) | 2005-08-10 |
DE60334985D1 (de) | 2010-12-30 |
US7150982B2 (en) | 2006-12-19 |
WO2003073067A2 (en) | 2003-09-04 |
JP4363988B2 (ja) | 2009-11-11 |
CN1302104C (zh) | 2007-02-28 |
CA2477698A1 (en) | 2003-09-04 |
EP2410049A1 (de) | 2012-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE488579T1 (de) | Rna-nachweisenzyme | |
ATE435909T1 (de) | Nachweis von rna | |
WO2001090337A3 (en) | Detection of rna | |
WO2002070755A3 (en) | Fen endonucleases | |
DK1634890T3 (da) | Invasiv klövning af nukleinsyrer | |
DE60131903D1 (de) | Direkte multiplex charakterisierung von genomischer dna | |
ATE414167T1 (de) | Fen-1 endonukleasen, gemische und spaltmethoden | |
ATE274587T1 (de) | 5'-nukleasen aus thermostabilen dna-polymerasen | |
WO2003048378A3 (en) | Methods and compositions for selectively cleaving dna containing duplex acids in a complex nucleic acid mixture | |
WO2001012862A3 (en) | Compositions and methods for preparing oligonucleotide solutions | |
DE60219579D1 (de) | Reversibel modifizierte thermostabile Enzyme für die in vitro-Synthese und -Amplifizierung von DNA | |
EP2058407A3 (de) | Invasive Spaltung von Nukleinsäuren | |
EA200401354A1 (ru) | Химерный олигонуклеотидный праймер для способа амплификации нуклеиновой кислоты; продукт для амплификации нуклеиновой кислоты; зонд для способа детекции нуклеиновой кислоты-мишени; материал с иммобилизованной амплифицированной нуклеиновой кислотой и способ его получения; способ определения нуклеотидной последовательности | |
ATE366822T1 (de) | Verfahren zum quantitativen nachweis von nukleinsäuren | |
ATE404695T1 (de) | Einfache katalytische dna-biosensoren für ionen auf grundlage von farbveränderungen | |
DE60335144D1 (de) | Nukleinsäureamplifikation | |
TW200700725A (en) | Detection of nucleic acid associated with disease | |
ATE484515T1 (de) | Dna-polymerase-mischungen und mutante dna- polymerasen | |
MXPA02010868A (es) | Secuencias de nucleotidos involucrados en el incremento o disminucion en la ovulacion mamifera. | |
PT1322753E (pt) | Novas redutases do acido 2,5-diceto-l-gluconico e metodos de utilizacao | |
ATE345390T1 (de) | Peptidylarginin deiminase 6 | |
ATE362986T1 (de) | High fidelity thermostabile ligase und ihre verwendung | |
BR0200030A (pt) | Sequências e métodos para detecção do hiv- 1 | |
Przykorska et al. | Structural specificity of Rn nuclease I as probed on yeast tRNAPhe and tRNAAsp | |
DE60127244D1 (de) | Spezifische multiplex-analyse von nukleinsäuren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |