ATE435909T1 - Nachweis von rna - Google Patents
Nachweis von rnaInfo
- Publication number
- ATE435909T1 ATE435909T1 AT01937745T AT01937745T ATE435909T1 AT E435909 T1 ATE435909 T1 AT E435909T1 AT 01937745 T AT01937745 T AT 01937745T AT 01937745 T AT01937745 T AT 01937745T AT E435909 T1 ATE435909 T1 AT E435909T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid sequences
- cleavage
- detection
- polymerases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/577,304 US6759226B1 (en) | 2000-05-24 | 2000-05-24 | Enzymes for the detection of specific nucleic acid sequences |
| US09/758,282 US6635463B2 (en) | 2000-05-24 | 2001-01-11 | Enzymes for the detection of nucleic acid sequences |
| US09/864,426 US20040018489A1 (en) | 1991-09-09 | 2001-05-24 | Detection of RNA |
| US09/864,636 US7045289B2 (en) | 1991-09-09 | 2001-05-24 | Detection of RNA Sequences |
| PCT/US2001/017086 WO2001090337A2 (en) | 2000-05-24 | 2001-05-24 | Detection of rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435909T1 true ATE435909T1 (de) | 2009-07-15 |
Family
ID=24308153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01937745T ATE435909T1 (de) | 2000-05-24 | 2001-05-24 | Nachweis von rna |
Country Status (3)
| Country | Link |
|---|---|
| US (5) | US6759226B1 (de) |
| AT (1) | ATE435909T1 (de) |
| DE (1) | DE60139200D1 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7118860B2 (en) * | 1999-10-29 | 2006-10-10 | Stratagene California | Methods for detection of a target nucleic acid by capture |
| JP4310599B2 (ja) * | 2000-07-05 | 2009-08-12 | 東洋紡績株式会社 | 塩基多型を検出する方法 |
| US7678541B2 (en) * | 2000-11-21 | 2010-03-16 | Hologic, Inc. | Methods and compositions for the detection of a nucleic acid using a non-invasive cleavage reaction |
| US7309573B2 (en) * | 2000-11-21 | 2007-12-18 | Stratagene California | Methods for detection of a nucleic acid by sequential amplification |
| CA2459718A1 (en) * | 2001-09-14 | 2003-08-14 | Applera Corporation | Thermus scotoductus nucleic acid polymerases |
| US20050042629A1 (en) * | 2002-09-13 | 2005-02-24 | Applera Corporation | Thermus scotoductus nucleic acid polymerases |
| EP1436385A4 (de) * | 2001-09-14 | 2005-12-14 | Invitrogen Corp | Dna-polymerasen und mutanten davon |
| WO2003048308A2 (en) | 2001-11-30 | 2003-06-12 | Applera Corporation | Thermus brockianus nucleic acid polymerases |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US7700750B2 (en) * | 2003-01-09 | 2010-04-20 | Third Wave Technologies, Inc. | Connexin allele detection assays |
| US20050053990A1 (en) * | 2003-09-08 | 2005-03-10 | Roberts Richard J. | Cleavage of RNA by restriction endonucleases |
| GB0325653D0 (en) * | 2003-11-03 | 2003-12-10 | Medical Res Council | CST emulsions |
| AU2004288017B2 (en) * | 2003-11-03 | 2009-10-08 | United Kingdom Research And Innovation | Polymerase |
| US20060029954A1 (en) * | 2004-06-30 | 2006-02-09 | Applera Corporation | Compositions and methods for identifying nucleotides in polynucleotide sequences |
| US7109297B2 (en) * | 2004-09-13 | 2006-09-19 | The Hong Kong Polytechnic University | Biomarkers for toxic algae |
| US7772390B1 (en) | 2006-07-18 | 2010-08-10 | The Regents Of The University Of California | Lipid mediated nucleic acid synthesis |
| US20090075259A1 (en) * | 2007-08-31 | 2009-03-19 | Carsten-Peter Carstens | Analyte detection via antibody-associated enzyme assay |
| BRPI0908748A2 (pt) | 2008-03-15 | 2015-07-28 | Hologic Inc | Composições e métodos para análise de moléculas de ácido nucleico durante reações de amplificação |
| WO2009155271A1 (en) * | 2008-06-17 | 2009-12-23 | Sigma-Aldrich Co. | Real time polymerase chain reaction process using a universal detection system |
| WO2010062777A2 (en) * | 2008-11-03 | 2010-06-03 | Kapabiosystems | Modified type a dna polymerases |
| EP2524036B1 (de) * | 2009-07-31 | 2019-06-12 | Agilent Technologies, Inc. | Wärmestabile dna-polymerasemutanten vom typ a mit erhöhter polymerisationsrate und resistenz gegenüber inhibitoren |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8715937B2 (en) | 2010-11-15 | 2014-05-06 | Exact Sciences Corporation | Mutation detection assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| US9315787B2 (en) | 2011-01-14 | 2016-04-19 | Kapa Biosystems, Inc. | Modified DNA polymerases for improved amplification |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| WO2014158628A1 (en) | 2013-03-14 | 2014-10-02 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules |
| WO2014210225A1 (en) | 2013-06-25 | 2014-12-31 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| US9409139B2 (en) | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| JP6267217B2 (ja) * | 2013-09-30 | 2018-01-24 | Ｎｅｃソリューションイノベータ株式会社 | ターゲットの分析方法および分析キット |
| CN106232814B (zh) | 2014-02-13 | 2021-05-11 | 宝生物工程（美国)有限公司 | 从核酸的初始集合中耗尽靶分子的方法、以及用于实践其的组合物和试剂盒 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| EP3530752B1 (de) | 2015-04-10 | 2021-03-24 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| AU2016324296A1 (en) | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| US11512347B2 (en) | 2015-09-22 | 2022-11-29 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
| US20210254035A1 (en) * | 2016-11-22 | 2021-08-19 | Toyobo Co., Ltd. | Modified heat-resistant dna polymerase |
| US10907274B2 (en) | 2016-12-16 | 2021-02-02 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| EP3595674A4 (de) | 2017-03-15 | 2020-12-16 | Twist Bioscience Corporation | Variante bibliotheken der immunologischen synapse und synthese davon |
| US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| EP3681906A4 (de) | 2017-09-11 | 2021-06-09 | Twist Bioscience Corporation | Gpcr-bindende proteine und deren synthese |
| GB2583590A (en) | 2017-10-20 | 2020-11-04 | Twist Bioscience Corp | Heated nanowells for polynucleotide synthesis |
| KR20200106067A (ko) | 2018-01-04 | 2020-09-10 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| WO2019143622A1 (en) * | 2018-01-19 | 2019-07-25 | Bio-Rad Laboratories, Inc. | Mutant dna polymerases |
| SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| EP3894587A1 (de) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Auflösung von räumlichen anordnungen durch nähebasierte dekonvolution |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| KR20210143766A (ko) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| WO2020176680A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| US11613738B2 (en) | 2019-05-14 | 2023-03-28 | Abclonal Science, Inc. | Mutant Taq polymerase resistant to inhibition of amplification in the presence of cyanine dye |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| EP4025711A2 (de) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Erhöhung der spezifität einer analytbindung |
| EP3891300B1 (de) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Verfahren zur räumlichen analyse mittels rna-template-ligation |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| WO2021216708A1 (en) | 2020-04-22 | 2021-10-28 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021237087A1 (en) * | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| EP4162074B1 (de) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon |
| WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| CN116034166A (zh) | 2020-06-25 | 2023-04-28 | 10X基因组学有限公司 | Dna甲基化的空间分析 |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| WO2022076415A1 (en) * | 2020-10-06 | 2022-04-14 | University Of Maryland, Baltimore | Rapid diagnostic electrochemical biosensing targeted with antisense oligonucleotides |
| CN112301020B (zh) * | 2020-10-19 | 2024-04-12 | 复旦大学附属肿瘤医院 | Iii类脱氧核酶突变体及其制备方法与应用 |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4196605A1 (de) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung |
| WO2023056345A1 (en) | 2021-09-30 | 2023-04-06 | Gen-Probe Incorporated | Temperature-selectable fret cassette signaling |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5795762A (en) | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5244797B1 (en) | 1988-01-13 | 1998-08-25 | Life Technologies Inc | Cloned genes encoding reverse transcriptase lacking rnase h activity |
| US7150982B2 (en) * | 1991-09-09 | 2006-12-19 | Third Wave Technologies, Inc. | RNA detection assays |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5459055A (en) | 1991-12-27 | 1995-10-17 | Epicentre Technologies Corporation | Thermostable ribonuclease H isolated from Thermus flavus |
| US5268289A (en) | 1991-12-27 | 1993-12-07 | Epicentre Technologies Corp. | Thermostable ribonuclease H |
| US5614402A (en) * | 1992-12-07 | 1997-03-25 | Third Wave Technologies, Inc. | 5' nucleases derived from thermostable DNA polymerase |
| US5541311A (en) | 1992-12-07 | 1996-07-30 | Third Wave Technologies, Inc. | Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5874283A (en) | 1995-05-30 | 1999-02-23 | John Joseph Harrington | Mammalian flap-specific endonuclease |
| EP0904286A4 (de) | 1996-01-24 | 2004-01-14 | Third Wave Tech Inc | Invasive spaltung von nukleinsäuren |
| US6090606A (en) | 1996-01-24 | 2000-07-18 | Third Wave Technologies, Inc. | Cleavage agents |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US5972603A (en) * | 1996-02-09 | 1999-10-26 | President And Fellows Of Harvard College | DNA polymerase with modified processivity |
| EP2374890B1 (de) | 1996-11-29 | 2012-11-14 | Third Wave Technologies, Inc. | FEN-1-Endonucleasen, Mischungen und Spaltungsverfahren |
| IL130635A0 (en) | 1997-01-17 | 2000-06-01 | Maxygen Inc | Evolution of whole cells and organisms by recursive sequence recombination |
| US6228628B1 (en) | 1997-07-09 | 2001-05-08 | Roche Molecular Systems | Mutant chimeric DNA polymerase |
| JP2002517995A (ja) | 1998-06-17 | 2002-06-25 | マキシジェン， インコーポレイテッド | 所望の特性を有するポリヌクレオチドを生成するための方法 |
| EP1117777A2 (de) | 1998-09-29 | 2001-07-25 | Maxygen, Inc. | Shuffling von gene mit veränderten kodons |
| US6659293B1 (en) | 1999-07-07 | 2003-12-09 | Odwalla, Inc. | Pull-out shelf stocking system |
| WO2001090337A2 (en) | 2000-05-24 | 2001-11-29 | Third Wave Technologies, Inc. | Detection of rna |
-
2000
- 2000-05-24 US US09/577,304 patent/US6759226B1/en not_active Expired - Lifetime
-
2001
- 2001-01-11 US US09/758,282 patent/US6635463B2/en not_active Expired - Lifetime
- 2001-05-24 DE DE60139200T patent/DE60139200D1/de not_active Expired - Lifetime
- 2001-05-24 AT AT01937745T patent/ATE435909T1/de not_active IP Right Cessation
-
2006
- 2006-12-19 US US11/642,815 patent/US7935800B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/929,404 patent/US7807806B2/en not_active Expired - Fee Related
-
2010
- 2010-10-05 US US12/898,490 patent/US8063184B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6759226B1 (en) | 2004-07-06 |
| US20030134349A1 (en) | 2003-07-17 |
| US7807806B2 (en) | 2010-10-05 |
| US6635463B2 (en) | 2003-10-21 |
| US8063184B2 (en) | 2011-11-22 |
| US20080293046A1 (en) | 2008-11-27 |
| US20110104682A1 (en) | 2011-05-05 |
| DE60139200D1 (de) | 2009-08-20 |
| US7935800B2 (en) | 2011-05-03 |
| US20090142754A1 (en) | 2009-06-04 |
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