ATE481378T1 - Verfahren zur herstellung von 1-alkoxycarbonyl-3- phenylpropylderivaten - Google Patents
Verfahren zur herstellung von 1-alkoxycarbonyl-3- phenylpropylderivatenInfo
- Publication number
- ATE481378T1 ATE481378T1 AT06005434T AT06005434T ATE481378T1 AT E481378 T1 ATE481378 T1 AT E481378T1 AT 06005434 T AT06005434 T AT 06005434T AT 06005434 T AT06005434 T AT 06005434T AT E481378 T1 ATE481378 T1 AT E481378T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- alkoxycarbonyl
- phenylpropyl
- producing
- ile
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11654596A JP3792777B2 (ja) | 1996-05-10 | 1996-05-10 | １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE481378T1 true ATE481378T1 (de) | 2010-10-15 |
Family
ID=14689775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06005434T ATE481378T1 (de) | 1996-05-10 | 1997-05-08 | Verfahren zur herstellung von 1-alkoxycarbonyl-3- phenylpropylderivaten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6118010A (forum.php) |
| EP (2) | EP0903337B1 (forum.php) |
| JP (1) | JP3792777B2 (forum.php) |
| KR (1) | KR100382633B1 (forum.php) |
| CN (1) | CN1159286C (forum.php) |
| AT (1) | ATE481378T1 (forum.php) |
| CA (1) | CA2254972C (forum.php) |
| DE (2) | DE69735667T2 (forum.php) |
| ES (2) | ES2353151T3 (forum.php) |
| HU (1) | HU227430B1 (forum.php) |
| IN (2) | IN183558B (forum.php) |
| SI (1) | SI9720039B (forum.php) |
| WO (1) | WO1997043246A1 (forum.php) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1200946C (zh) * | 1998-09-22 | 2005-05-11 | 钟渊化学工业株式会社 | 制备n2－(1(s)－羧基－3－苯基丙基)－l－赖氨酰－l－脯氨酸的方法 |
| AU2000239828A1 (en) * | 2000-04-18 | 2001-10-30 | Scinopharm Singapore Pte Ltd | Process for preparation of 3-((1'-(alkoxycarbonyl)-3'-phenylpropyl)amino)-2-oxo-(1)- benzazepine and its derivatives |
| AR033048A1 (es) | 2001-03-19 | 2003-12-03 | Kaneka Corp | Metodo para la purificacion de la n-(1(s)-etoxicarbonil-3-fenilpropil) -l-alanina |
| JP2003026644A (ja) * | 2001-07-11 | 2003-01-29 | Kanegafuchi Chem Ind Co Ltd | Ｎ２−（１（ｓ）−エトキシカルボニル−３−フェニルプロピル）−ｎ６−トリフルオロアセチル−ｌ−リジンの精製方法 |
| SI21101A (sl) * | 2001-11-26 | 2003-06-30 | LEK farmacevtska dru�ba d.d. | Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo |
| ATE335757T1 (de) * | 2002-06-19 | 2006-09-15 | Eos Eczacibasi Ozgun Kimyasal | Verfahren zur herstellung von lisinopril |
| JP4744979B2 (ja) * | 2005-08-24 | 2011-08-10 | 独立行政法人理化学研究所 | ゼオライトを用いたタンパク質結晶化方法 |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| CN101239923B (zh) * | 2007-12-31 | 2010-09-15 | 浙江工业大学 | (s,s)n-(1-乙氧羰基-3-苯丙基)-l-氨基酸衍生物的制备方法与精制方法 |
| MX355543B (es) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Macrociclos peptidomiméticos. |
| CN101973904B (zh) * | 2010-09-28 | 2014-01-01 | 雅本化学股份有限公司 | 一种具有高光学纯度的n2-[1-(s)-乙氧羰基-3-苯丙基]-n6-三氟乙酰基-l-赖氨酸的制备方法 |
| US9096684B2 (en) | 2011-10-18 | 2015-08-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2013221433B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
| JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス，インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
| CN105294827A (zh) * | 2014-07-21 | 2016-02-03 | 常州制药厂有限公司 | 一种马来酸依那普利的制备方法 |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN106220545B (zh) * | 2016-07-21 | 2019-08-13 | 成都摩尔生物医药有限公司 | 一种acei药物环己基杂质的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1327787A3 (ru) * | 1981-11-05 | 1987-07-30 | Хехст Аг (Фирма) | Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей |
| DE3246503A1 (de) * | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| EP0190687B1 (en) * | 1985-02-04 | 1988-10-05 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate |
| DE3770301D1 (de) * | 1986-03-27 | 1991-07-04 | Kanegafuchi Chemical Ind | N2-(1-carboxy-3-oxo-3-phenylpropyl)-l-lysinverbindungen und deren abkoemmlinge. |
| JPH01104034A (ja) * | 1986-03-27 | 1989-04-21 | Kanegafuchi Chem Ind Co Ltd | Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体の製造法 |
| JPS62239062A (ja) * | 1986-04-11 | 1987-10-19 | Matsushita Electric Ind Co Ltd | 交差コイル式メ−タの駆動回路 |
| JPH03115254A (ja) * | 1990-09-12 | 1991-05-16 | Kanegafuchi Chem Ind Co Ltd | α―（１―カルボキシエチル）アミノ―γ―フエニル酪酸エチルの製造法 |
| JPH06336495A (ja) * | 1993-05-28 | 1994-12-06 | Kyowa Hakko Kogyo Co Ltd | Ｌ−アラニル−ｌ−プロリン誘導体の製造法 |
-
1996
- 1996-05-10 JP JP11654596A patent/JP3792777B2/ja not_active Expired - Fee Related
-
1997
- 1997-05-08 EP EP97918383A patent/EP0903337B1/en not_active Expired - Lifetime
- 1997-05-08 EP EP06005434A patent/EP1679303B1/en not_active Expired - Lifetime
- 1997-05-08 US US09/147,255 patent/US6118010A/en not_active Expired - Lifetime
- 1997-05-08 KR KR10-1998-0708981A patent/KR100382633B1/ko not_active Expired - Fee Related
- 1997-05-08 CA CA002254972A patent/CA2254972C/en not_active Expired - Fee Related
- 1997-05-08 HU HU9903214A patent/HU227430B1/hu not_active IP Right Cessation
- 1997-05-08 SI SI9720039A patent/SI9720039B/sl not_active IP Right Cessation
- 1997-05-08 CN CNB971945292A patent/CN1159286C/zh not_active Expired - Lifetime
- 1997-05-08 ES ES06005434T patent/ES2353151T3/es not_active Expired - Lifetime
- 1997-05-08 DE DE69735667T patent/DE69735667T2/de not_active Expired - Lifetime
- 1997-05-08 ES ES97918383T patent/ES2257775T3/es not_active Expired - Lifetime
- 1997-05-08 DE DE69739998T patent/DE69739998D1/de not_active Expired - Lifetime
- 1997-05-08 WO PCT/JP1997/001543 patent/WO1997043246A1/ja active IP Right Grant
- 1997-05-08 AT AT06005434T patent/ATE481378T1/de not_active IP Right Cessation
- 1997-05-09 IN IN838CA1997 patent/IN183558B/en unknown
-
1998
- 1998-09-24 IN IN1723CA1998 patent/IN187140B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1679303B1 (en) | 2010-09-15 |
| DE69735667D1 (de) | 2006-05-24 |
| ES2353151T3 (es) | 2011-02-25 |
| CA2254972A1 (en) | 1997-11-20 |
| ES2257775T3 (es) | 2006-08-01 |
| SI9720039B (sl) | 2002-02-28 |
| WO1997043246A1 (en) | 1997-11-20 |
| HU227430B1 (hu) | 2011-06-28 |
| IN187140B (forum.php) | 2002-02-09 |
| EP0903337A1 (en) | 1999-03-24 |
| JPH09301938A (ja) | 1997-11-25 |
| EP0903337A4 (en) | 2001-02-28 |
| CA2254972C (en) | 2005-08-02 |
| HUP9903214A3 (en) | 2002-12-28 |
| SI9720039A (sl) | 1999-08-31 |
| KR100382633B1 (ko) | 2003-07-12 |
| KR20000010840A (ko) | 2000-02-25 |
| CN1159286C (zh) | 2004-07-28 |
| US6118010A (en) | 2000-09-12 |
| DE69739998D1 (de) | 2010-10-28 |
| IN183558B (forum.php) | 2000-02-12 |
| CN1218454A (zh) | 1999-06-02 |
| EP1679303A1 (en) | 2006-07-12 |
| DE69735667T2 (de) | 2007-04-26 |
| EP0903337B1 (en) | 2006-04-12 |
| JP3792777B2 (ja) | 2006-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |