ATE452683T1 - 3'- (2z)- 1-(3,4-dimethylphenyl)-1,5-dihydro-3- methyl-5-oxo-4h-pyrazol-4-yliden hydrazino -2'- hydroxy- 1,1'-biphenyl -3-carbonsaure-bis- (monoethanolamin) - Google Patents
3'- (2z)- 1-(3,4-dimethylphenyl)-1,5-dihydro-3- methyl-5-oxo-4h-pyrazol-4-yliden hydrazino -2'- hydroxy- 1,1'-biphenyl -3-carbonsaure-bis- (monoethanolamin)Info
- Publication number
- ATE452683T1 ATE452683T1 AT03731335T AT03731335T ATE452683T1 AT E452683 T1 ATE452683 T1 AT E452683T1 AT 03731335 T AT03731335 T AT 03731335T AT 03731335 T AT03731335 T AT 03731335T AT E452683 T1 ATE452683 T1 AT E452683T1
- Authority
- AT
- Austria
- Prior art keywords
- yliden
- hydrazino
- dimethylphenyl
- monoethanolamine
- pyrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38287102P | 2002-05-22 | 2002-05-22 | |
PCT/US2003/016255 WO2003098992A2 (en) | 2002-05-22 | 2003-05-21 | 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE452683T1 true ATE452683T1 (de) | 2010-01-15 |
Family
ID=29584468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03731335T ATE452683T1 (de) | 2002-05-22 | 2003-05-21 | 3'- (2z)- 1-(3,4-dimethylphenyl)-1,5-dihydro-3- methyl-5-oxo-4h-pyrazol-4-yliden hydrazino -2'- hydroxy- 1,1'-biphenyl -3-carbonsaure-bis- (monoethanolamin) |
Country Status (29)
Country | Link |
---|---|
US (6) | US7547719B2 (de) |
EP (2) | EP2206533A3 (de) |
JP (2) | JP4612414B2 (de) |
KR (2) | KR101090643B1 (de) |
CN (1) | CN100542530C (de) |
AR (1) | AR040083A1 (de) |
AT (1) | ATE452683T1 (de) |
AU (1) | AU2003241587B2 (de) |
BR (1) | BRPI0310094B8 (de) |
CA (1) | CA2486697C (de) |
CY (1) | CY1109912T1 (de) |
DE (1) | DE60330674D1 (de) |
DK (1) | DK1534390T3 (de) |
ES (1) | ES2338108T3 (de) |
HK (1) | HK1078039A1 (de) |
IL (2) | IL164966A0 (de) |
IS (1) | IS2770B (de) |
LT (1) | LTC1534390I2 (de) |
MX (1) | MXPA04011522A (de) |
MY (1) | MY142390A (de) |
NO (1) | NO330160B1 (de) |
NZ (1) | NZ536272A (de) |
PL (1) | PL212682B1 (de) |
PT (1) | PT1534390E (de) |
RU (1) | RU2284994C9 (de) |
SI (1) | SI1534390T1 (de) |
TW (1) | TWI280128B (de) |
WO (1) | WO2003098992A2 (de) |
ZA (1) | ZA200408701B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110212054A1 (en) * | 2000-05-25 | 2011-09-01 | Glaxosmithkline Llc. | Thrombopoietin mimetics |
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
AR040083A1 (es) | 2002-05-22 | 2005-03-16 | Smithkline Beecham Corp | Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac |
US20090048318A1 (en) * | 2003-04-29 | 2009-02-19 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
US20100004302A1 (en) * | 2003-04-29 | 2010-01-07 | Connie Erickson-Miller | Methods for Treating Degenerative Diseases/Injuries |
EP2387998A1 (de) | 2003-04-29 | 2011-11-23 | Glaxosmithkline LLC | Verfahren zur Behandlung von degenerativen Erkrankungen/Verletzungen |
US20090298179A1 (en) * | 2003-04-29 | 2009-12-03 | Connie Erickson-Miller | Methods For Treating Degenerative Diseases/Injuries |
US20090143453A1 (en) * | 2003-04-29 | 2009-06-04 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
WO2005118551A2 (en) | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
AU2005299720B2 (en) | 2004-10-25 | 2010-02-04 | Ligand Pharmaceuticals Incorporated | Thrombopoietin activity modulating compounds and methods |
JP2009511603A (ja) * | 2005-10-13 | 2009-03-19 | スミスクライン・ビーチャム・コーポレイション | 貯蔵中の血小板の有効性を維持する方法 |
WO2007062078A2 (en) * | 2005-11-23 | 2007-05-31 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
EP2021846B1 (de) | 2006-05-19 | 2017-05-03 | Koninklijke Philips N.V. | Ablationsvorrichtung mit optimiertem eingangsleistungsprofil |
US20090304634A1 (en) * | 2006-12-12 | 2009-12-10 | Smithkline Beecham Corporation | Novel Combinations |
US20110129550A1 (en) | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
UY30915A1 (es) | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
AU2012201288B2 (en) * | 2007-05-03 | 2014-05-01 | Novartis Ag | Novel pharmaceutical composition |
US20090088371A1 (en) * | 2007-08-28 | 2009-04-02 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
EP2211855A4 (de) * | 2007-10-09 | 2011-12-07 | Univ Pennsylvania | Thrombopoetin-rezeptor-agonist (tpora) vernichtet akute myeloische leukämiezellen beim menschen |
CN101481352A (zh) * | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
CN102448942A (zh) | 2009-04-01 | 2012-05-09 | 普利瓦赫尔瓦茨卡有限公司 | 艾曲波帕和艾曲波帕盐的多晶型物及其制备方法 |
US8476249B2 (en) | 2009-05-07 | 2013-07-02 | Glaxosmithkline Llc | Method of treating thrombocytopenia |
JP2012528184A (ja) | 2009-05-29 | 2012-11-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | トロンボポエチンアゴニスト化合物の投与の方法 |
CN101921232A (zh) * | 2009-06-11 | 2010-12-22 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用 |
US9440927B2 (en) | 2011-09-13 | 2016-09-13 | Glenmark Pharmaceuticals Limited | Process for preparation of substituted 3'-hydroazino-diphenyl-3-carboxylic acid compounds |
GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
JP6584956B2 (ja) | 2012-12-21 | 2019-10-02 | アステラス インスティテュート フォー リジェネレイティブ メディシン | 多能性幹細胞から血小板を生産するための方法およびその組成物 |
US9770437B2 (en) | 2013-09-02 | 2017-09-26 | Hetero Research Foundation | Compositions of eltrombopag |
WO2015111085A2 (en) | 2014-01-27 | 2015-07-30 | Cadila Healthcare Limited | Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof |
US10298884B2 (en) * | 2014-05-09 | 2019-05-21 | Honeywell International Inc. | System and method of precision remote PTZ control of IP cameras |
WO2016035018A1 (en) | 2014-09-05 | 2016-03-10 | Hetero Research Foundation | Crystalline form of eltrombopag free acid |
WO2016055935A1 (en) | 2014-10-06 | 2016-04-14 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist |
WO2017042839A1 (en) | 2015-09-08 | 2017-03-16 | Actavis Group Ptc Ehf. | Novel eltrombopag salt and preparation thereof |
US20180273490A1 (en) * | 2015-11-10 | 2018-09-27 | Amneal Pharmaceuticals Company Gmbh | Process for the Preparation of Eltrombopag Olamine |
CN106361719A (zh) * | 2016-08-25 | 2017-02-01 | 浙江万晟药业有限公司 | 一种艾曲泊帕液体胶囊及其制备方法 |
CN106966984A (zh) * | 2017-04-01 | 2017-07-21 | 常州制药厂有限公司 | 艾曲波帕二乙醇胺盐的制备方法 |
EP3395331B1 (de) | 2017-04-26 | 2019-08-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmazeutische tablettenzusammensetzung umfassend eltrombopagolamin |
US11072586B2 (en) | 2017-10-06 | 2021-07-27 | Assia Chemical Industries Ltd. | Solid state forms of eltrombopag choline |
EP3409272B1 (de) | 2018-03-07 | 2020-06-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmazeutische zusammensetzung mit eltrombopag olamin, reduzierendem zucker und polymerem bindemittel |
ES2815924T3 (es) | 2018-08-02 | 2021-03-31 | Fis Fabbrica Italiana Sintetici Spa | Forma D1 cristalina altamente estable de la sal de monoetanolamina de eltrombopag |
EP3604284B1 (de) | 2018-08-02 | 2020-11-11 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Kristalline form d des eltrombopag-monoethanolamin-salzes |
TR202014694A1 (tr) | 2020-09-16 | 2022-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon |
WO2023111187A1 (en) | 2021-12-15 | 2023-06-22 | Galenicum Health, S.L.U | Pharmaceutical compositions comprising eltrombopag |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE193350C (de) | ||||
US851444A (en) | 1905-11-13 | 1907-04-23 | Agfa Ag | Amido-oxy-sulfonic acid of phenylnaphthimidazol and process of making same. |
GB779880A (en) | 1953-02-27 | 1957-07-24 | Ciba Ltd | Functional derivatives of azo-dyestuffs containing sulphonic acid groups and processfor making them |
US2809963A (en) | 1954-10-26 | 1957-10-15 | Ciba Ltd | Azo-dyestuffs |
DE1046220B (de) | 1956-04-21 | 1958-12-11 | Bayer Ag | Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen |
GB826207A (en) | 1956-07-23 | 1959-12-31 | Bayer Ag | ú´-ú´-dihydroxy-monoazo dyestuffs containing pyrrolidonyl residues and their metal complex compounds |
US2950273A (en) | 1956-11-20 | 1960-08-23 | Agfa Ag | Process for the production of symmetrical and unsymmetrical azo compounds |
US3366619A (en) | 1965-04-09 | 1968-01-30 | Interchem Corp | Disazo pyrazolone pigments |
US4435417A (en) | 1981-02-20 | 1984-03-06 | Gruppo Lepetit S.P.A. | Antiinflammatory 3H-naphtho[1,2-d]imidazoles |
JPS58103432A (ja) * | 1981-12-14 | 1983-06-20 | 富士写真フイルム株式会社 | 固体撮像素子を用いた内視鏡装置 |
ES523609A0 (es) | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
SU1162799A1 (ru) * | 1982-07-09 | 1985-06-23 | Витебский государственный медицинский институт | Способ получени 4-арилгидразонов пиразолидинтриона-3,4,5 |
FR2559483B1 (fr) | 1984-02-10 | 1986-12-05 | Sandoz Sa | Composes heterocycliques contenant des groupes basiques et/ou cationiques, leur preparation et leur utilisation comme colorants |
US4582831A (en) | 1984-11-16 | 1986-04-15 | Pfizer Inc. | Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor |
FI91869C (fi) | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
US4880788A (en) | 1987-10-30 | 1989-11-14 | Baylor College Of Medicine | Method for preventing and treating thrombosis |
WO1993017681A1 (en) | 1992-03-02 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
IL109570A0 (en) | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
EP0638617A1 (de) | 1993-08-13 | 1995-02-15 | Ciba-Geigy Ag | Pigmentsalze |
DE69412987T2 (de) | 1993-12-28 | 1999-05-27 | Dainippon Printing Co Ltd | Thermische Übertragungsschicht |
US5482546A (en) | 1994-03-30 | 1996-01-09 | Canon Kabushiki Kaisha | Dye, ink containing the same, and ink-jet recording method and instrument using the ink |
US5760038A (en) | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5746821A (en) | 1995-02-13 | 1998-05-05 | Engelhard Corporation | Pigment compositions |
ZA964814B (en) | 1995-06-07 | 1998-02-09 | Glaxo Group Ltd | Peptides and compounds that bind to a receptor. |
US5622818A (en) | 1995-11-29 | 1997-04-22 | Eastman Kodak Company | Color photographic elements containing yellow colored magenta dye forming masking couplers |
US5669967A (en) | 1996-05-30 | 1997-09-23 | Engelhard Corporation | Pigment compositions |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
GB9715830D0 (en) | 1997-07-25 | 1997-10-01 | Basf Ag | Reactive dyes containing piperazine |
AU9265698A (en) | 1997-09-02 | 1999-03-22 | Boehringer Mannheim Gmbh | Mpl-receptor ligands, process for their preparation, medicaments containing themand their use for the treatment and prevention of thrombocytopaenia and anaemia |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
CA2308317A1 (en) | 1997-10-31 | 1999-05-14 | Smithkline Beecham Corporation | Novel metal complexes |
DE19851389A1 (de) | 1998-11-07 | 2000-05-11 | Dystar Textilfarben Gmbh & Co | Gelbe Farbstoffmischungen von wasserlöslichen faserreaktiven Azofarbstoffen und ihre Verwendung |
GC0000177A (en) | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
US6265578B1 (en) * | 1999-02-12 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrimidine-2,4,6-triones |
CO5210907A1 (es) | 1999-05-12 | 2002-10-30 | Novartis Ag | Solvatos de pometrozina, insecticidamente activos, composiciones que contienen estos compuestos y metodos tanto para producir dichos compuestos y composiciones como para controlar plagas animales con estas composiciones |
EP1207155A4 (de) | 1999-07-26 | 2005-01-12 | Shionogi & Co | Medikamentzusammensetzung mit thrombopoietin-agonistischer wirkung |
ES2256038T3 (es) | 1999-09-10 | 2006-07-16 | Smithkline Beecham Corporation | Mimeticos de trombopoyetina. |
ES2279769T3 (es) | 1999-09-24 | 2007-09-01 | Smithkline Beecham Corporation | Mimeticos de trombopoyetina. |
WO2001034585A1 (en) | 1999-11-05 | 2001-05-17 | Smithkline Beecham Corporation | Semicarbazone derivatives and their use as thrombopoietin mimetics |
ES2160560T1 (es) | 1999-11-10 | 2001-11-16 | Curacyte Ag | Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias. |
GB9928805D0 (en) * | 1999-12-07 | 2000-02-02 | Karobio Ab | Compounds active at the Glucocorticoid and Thyroid Hormone Receptors |
TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
HUP0001417A2 (hu) | 2000-04-07 | 2002-12-28 | Sanofi-Synthelabo | Gyógyászatilag alkalmazható új sók, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények |
US6214813B1 (en) | 2000-04-07 | 2001-04-10 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
US6436915B1 (en) | 2000-04-07 | 2002-08-20 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
WO2002039099A2 (en) | 2000-11-13 | 2002-05-16 | Koninklijke Philips Electronics N.V. | Measurement of surface defects |
EP1349613A4 (de) | 2000-12-19 | 2005-09-21 | Smithkline Beecham Corp | Thrombopoietinmimetika |
WO2002057300A1 (en) | 2000-12-21 | 2002-07-25 | Smithkline Beecham Corporation | Regulated activation of cell-membrane receptors by metal-chelating agonists |
US7169931B2 (en) | 2001-01-26 | 2007-01-30 | Shionogi & Co., Ltd. | Cyclic compounds exhibiting thrombopoietin receptor agonism |
US20040063764A1 (en) | 2001-01-26 | 2004-04-01 | Hiroshi Takemoto | Halogen compounds having thrombopoietin receptor agonism |
EP1370252A4 (de) | 2001-03-01 | 2006-04-05 | Smithkline Beecham Corp | Thrombopoietin-mimetika |
JP3927001B2 (ja) | 2001-06-15 | 2007-06-06 | 三菱化学株式会社 | 色素セット、インクセット並びに記録方法 |
JP2005519878A (ja) | 2001-11-30 | 2005-07-07 | キネテク ファーマシューティカルズ,インコーポレーテッド | ヒドラゾノピラゾール誘導体および治療剤としてのその使用 |
AU2003213673A1 (en) | 2002-03-01 | 2003-09-16 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
AR040083A1 (es) | 2002-05-22 | 2005-03-16 | Smithkline Beecham Corp | Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac |
AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2004054515A2 (en) | 2002-12-13 | 2004-07-01 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
EP2387998A1 (de) | 2003-04-29 | 2011-11-23 | Glaxosmithkline LLC | Verfahren zur Behandlung von degenerativen Erkrankungen/Verletzungen |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
-
2003
- 2003-05-20 AR ARP030101754A patent/AR040083A1/es unknown
- 2003-05-20 TW TW092113526A patent/TWI280128B/zh active
- 2003-05-20 MY MYPI20031857A patent/MY142390A/en unknown
- 2003-05-21 EP EP09180059A patent/EP2206533A3/de not_active Withdrawn
- 2003-05-21 AU AU2003241587A patent/AU2003241587B2/en active Active
- 2003-05-21 BR BRPI0310094A patent/BRPI0310094B8/pt active IP Right Grant
- 2003-05-21 EP EP03731335A patent/EP1534390B1/de not_active Expired - Lifetime
- 2003-05-21 MX MXPA04011522A patent/MXPA04011522A/es active IP Right Grant
- 2003-05-21 AT AT03731335T patent/ATE452683T1/de active
- 2003-05-21 RU RU2004137491A patent/RU2284994C9/ru active Protection Beyond IP Right Term
- 2003-05-21 CA CA002486697A patent/CA2486697C/en not_active Expired - Lifetime
- 2003-05-21 PT PT03731335T patent/PT1534390E/pt unknown
- 2003-05-21 US US10/515,304 patent/US7547719B2/en not_active Expired - Lifetime
- 2003-05-21 NZ NZ536272A patent/NZ536272A/en not_active IP Right Cessation
- 2003-05-21 KR KR1020047018687A patent/KR101090643B1/ko active IP Right Grant
- 2003-05-21 WO PCT/US2003/016255 patent/WO2003098992A2/en active Application Filing
- 2003-05-21 PL PL372440A patent/PL212682B1/pl unknown
- 2003-05-21 ES ES03731335T patent/ES2338108T3/es not_active Expired - Lifetime
- 2003-05-21 DK DK03731335.0T patent/DK1534390T3/da active
- 2003-05-21 SI SI200331773T patent/SI1534390T1/sl unknown
- 2003-05-21 DE DE60330674T patent/DE60330674D1/de not_active Expired - Lifetime
- 2003-05-21 JP JP2004506532A patent/JP4612414B2/ja not_active Expired - Lifetime
- 2003-05-21 CN CNB038113708A patent/CN100542530C/zh not_active Expired - Lifetime
- 2003-05-21 KR KR1020117022774A patent/KR20110113216A/ko not_active Application Discontinuation
-
2004
- 2004-10-27 ZA ZA200408701A patent/ZA200408701B/en unknown
- 2004-11-01 IL IL16496604A patent/IL164966A0/xx active IP Right Grant
- 2004-11-30 IS IS7573A patent/IS2770B/is unknown
- 2004-12-20 NO NO20045561A patent/NO330160B1/no not_active IP Right Cessation
-
2005
- 2005-11-09 HK HK05110019.1A patent/HK1078039A1/xx not_active IP Right Cessation
-
2009
- 2009-05-27 US US12/472,819 patent/US7795293B2/en not_active Expired - Lifetime
- 2009-06-18 IL IL199438A patent/IL199438A/en active IP Right Grant
-
2010
- 2010-03-09 CY CY20101100223T patent/CY1109912T1/el unknown
- 2010-05-10 LT LTPA2010007C patent/LTC1534390I2/lt unknown
- 2010-08-20 JP JP2010185078A patent/JP2010265317A/ja not_active Withdrawn
- 2010-09-01 US US12/873,565 patent/US8088813B2/en not_active Expired - Fee Related
-
2011
- 2011-12-22 US US13/334,770 patent/US20120189576A1/en not_active Abandoned
-
2013
- 2013-10-10 US US14/050,976 patent/US8846024B2/en not_active Expired - Fee Related
-
2014
- 2014-09-05 US US14/478,134 patent/US20150079030A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE452683T1 (de) | 3'- (2z)- 1-(3,4-dimethylphenyl)-1,5-dihydro-3- methyl-5-oxo-4h-pyrazol-4-yliden hydrazino -2'- hydroxy- 1,1'-biphenyl -3-carbonsaure-bis- (monoethanolamin) | |
DK1542961T3 (da) | Trans-4-(3,4-dichlorphenyl)-1,2,3,4-tetrahydro-1-napthalenamin til anvendelse til behandling af cns-forstyrrelser | |
NO20041075L (no) | Ny 1, 2, 4-triazolforbindelse | |
IS8461A (is) | 2-(3,4-dímetýlfenýl)-4-{[2-hýdroxý-3'(1H-tetrasól-5-ýl)bífenýl-3-ýl]-hýdrasónó}-5-metýl-2,4-díhýdrópýrasól-3-ónkólín | |
DE60216115D1 (de) | BENZIMIDAZO 4,5-föISOCHINOLINON-DERIVATE | |
ATE308544T1 (de) | N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren | |
ATE304015T1 (de) | Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren | |
NO20050676L (no) | Krystallinsk 2,5-dion-3-(1-metyl-lH-indol-3-yl)-4-[1-(pyridin-2-ylmetyl)piperidin-4-yl]-1H-indol-3-yl]-IH-pyrrol monohydroklorid. | |
ATE419254T1 (de) | 5-ää(2,3-difluorophenyl)methylüthioü-7-ää2- hydroxy-1-(hydroxymethyl)-1- | |
NO20030868D0 (no) | N-(3,5-diklor-2-metoksyfenyl)-4-metoksy-3-piperazin-1-yl- benzensulfonamid | |
DE60315471D1 (de) | 2,5-disubstituierte 3-mercaptopentansaure | |
ATE285408T1 (de) | Paroxetin-n-formyl-derivate | |
ES1048244Y (es) | Jamonero perfeccionado. | |
ITMI20021328A1 (it) | Nuove piperazine 1,4 - disostituite | |
ITRM20020187U1 (it) | Dispositivo per la protezione di serrature. | |
ES1050967Y (es) | Bloque ceramico perfeccionado. | |
DE50214487D1 (de) | Substituierte 1,5-diaminopentan-3-ol-verbindungen | |
ES1052347Y (es) | Grapa sujetacables perfeccionada | |
ES1051038Y (es) | Sofa perfeccionado. | |
ES1053443Y (es) | Pijama perfeccionado. | |
ITMC20020043A0 (it) | "macchina per la bricchettatura". | |
ES1050865Y (es) | Archivador plegable perfeccionado. | |
ITMC20020044A0 (it) | "composizione polimerica per la bricchettatura". | |
ES1051866Y (es) | Mampara plegable mejorada. | |
DOP2002000452A (es) | Pct 2002 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1534390 Country of ref document: EP |