EP1370252A4 - Thrombopoietin-mimetika - Google Patents
Thrombopoietin-mimetikaInfo
- Publication number
- EP1370252A4 EP1370252A4 EP02728383A EP02728383A EP1370252A4 EP 1370252 A4 EP1370252 A4 EP 1370252A4 EP 02728383 A EP02728383 A EP 02728383A EP 02728383 A EP02728383 A EP 02728383A EP 1370252 A4 EP1370252 A4 EP 1370252A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thrombopoietin mimetics
- thrombopoietin
- mimetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26995801P | 2001-03-01 | 2001-03-01 | |
US269958P | 2001-03-01 | ||
PCT/US2002/006259 WO2002085343A1 (en) | 2001-03-01 | 2002-03-01 | Thrombopoietin mimetics |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1370252A1 EP1370252A1 (de) | 2003-12-17 |
EP1370252A4 true EP1370252A4 (de) | 2006-04-05 |
Family
ID=23029313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02728383A Withdrawn EP1370252A4 (de) | 2001-03-01 | 2002-03-01 | Thrombopoietin-mimetika |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1370252A4 (de) |
WO (1) | WO2002085343A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
TWI280128B (en) | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
AU2003255030A1 (en) | 2002-08-14 | 2004-03-03 | Nissan Chemical Industries, Ltd. | Thrombopoetin receptor activator and process for producing the same |
TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
EP1622609A4 (de) * | 2003-04-29 | 2008-09-03 | Smithkline Beecham Corp | Verfahren zur behandlung von degenerativen erkrankungen/verletzungen |
CN100443472C (zh) * | 2003-06-06 | 2008-12-17 | 日产化学工业株式会社 | 3-亚烷基肼基取代的杂芳基化合物以及含有其的药物 |
UA82695C2 (uk) | 2003-06-06 | 2008-05-12 | Нисан Кемикал Индастриз, Лтд. | Гетероароматичні сполуки як активатори рецептора тромбопоетину |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
RU2395505C2 (ru) | 2004-12-08 | 2010-07-27 | Ниссан Кемикал Индастриз, ЛТД | 3-этилиденгидразино-замещенные гетероциклические соединения в качестве активаторов рецептора тромбопоэтина |
AU2005314788B2 (en) | 2004-12-14 | 2011-09-22 | Nissan Chemical Industries, Ltd. | Amide compound and thrombopoietin receptor activator |
JP5071375B2 (ja) | 2005-07-15 | 2012-11-14 | 日産化学工業株式会社 | チオフェン化合物及びトロンボポエチンレセプター活性化剤 |
TWI330184B (en) | 2005-07-20 | 2010-09-11 | Nissan Chemical Ind Ltd | Pyrazole compounds and thrombopoietin receptor activators |
US8026368B2 (en) | 2005-11-07 | 2011-09-27 | Nissan Chemical Industries, Ltd. | Hydrazide compounds and thrombopoietin receptor activators |
EP1951667A2 (de) * | 2005-11-23 | 2008-08-06 | Ligand Pharmaceuticals, Inc. | Thrombopoietinaktivitätsmodulierende verbindungen und verfahren |
JP5157900B2 (ja) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
EA024557B1 (ru) | 2009-05-29 | 2016-09-30 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Способы введения соединений, являющихся агонистами тромбопоэтина |
WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
UA109287C2 (uk) * | 2010-11-02 | 2015-08-10 | Солі органічного аміну похідних амінобензойної кислоти і спосіб їх одержання | |
WO2012102937A2 (en) | 2011-01-25 | 2012-08-02 | Irm Llc | Compounds that expand hematopoietic stem cells |
CA2858069C (en) | 2011-12-08 | 2020-02-11 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
WO2013110198A1 (en) | 2012-01-27 | 2013-08-01 | Université de Montréal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
CN104628647A (zh) * | 2013-11-12 | 2015-05-20 | 上海医药工业研究院 | 3-甲基-1-(3,4-二甲基苯基)-2-吡唑啉-5-酮的制备方法 |
EP3134409B1 (de) | 2014-04-22 | 2020-02-12 | Université de Montréal | Verbindungen und verwendung davon in der expansion von hämatopoietischen stammzellen und/oder hämatopoietischen vorläuferzellen |
WO2016068270A1 (ja) | 2014-10-31 | 2016-05-06 | 日産化学工業株式会社 | リガンド結合繊維及び当該繊維を用いた細胞培養基材 |
CN110467531B (zh) * | 2018-05-09 | 2022-04-19 | 新发药业有限公司 | 一种3’-硝基-2’-羟基联苯-3-甲酸的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035446A1 (en) * | 1998-12-17 | 2000-06-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2001017349A1 (en) * | 1999-09-10 | 2001-03-15 | Smithkline Beckman Corporation | Thrombopoietin mimetics |
WO2001089457A2 (en) * | 2000-05-25 | 2001-11-29 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
-
2002
- 2002-03-01 EP EP02728383A patent/EP1370252A4/de not_active Withdrawn
- 2002-03-01 WO PCT/US2002/006259 patent/WO2002085343A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035446A1 (en) * | 1998-12-17 | 2000-06-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2001017349A1 (en) * | 1999-09-10 | 2001-03-15 | Smithkline Beckman Corporation | Thrombopoietin mimetics |
WO2001089457A2 (en) * | 2000-05-25 | 2001-11-29 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
Non-Patent Citations (2)
Title |
---|
EL LATIF, F. M. A.: "An improved synthesis of pyrazolo(3,4-b)(1,5) , benzoxazepine, -benzothiazepine and -benzodiazepine derivatives via a convenient one-pot synthesis.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 37, no. 6, 2000, US HETEROCORPORATION. PROVO., pages 1659 - 1662, XP002366337 * |
See also references of WO02085343A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002085343A1 (en) | 2002-10-31 |
EP1370252A1 (de) | 2003-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030925 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060222 |
|
17Q | First examination report despatched |
Effective date: 20061214 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: GLAXOSMITHKLINE LLC |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100615 |