ATE442373T1 - Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden - Google Patents
Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methodenInfo
- Publication number
- ATE442373T1 ATE442373T1 AT96924334T AT96924334T ATE442373T1 AT E442373 T1 ATE442373 T1 AT E442373T1 AT 96924334 T AT96924334 T AT 96924334T AT 96924334 T AT96924334 T AT 96924334T AT E442373 T1 ATE442373 T1 AT E442373T1
- Authority
- AT
- Austria
- Prior art keywords
- delta
- analogs
- derivatives
- domain
- protein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title 1
- 101000914947 Bungarus multicinctus Long neurotoxin homolog TA-bm16 Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 2
- 101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 abstract 1
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000269370 Xenopus <genus> Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58995P | 1995-06-28 | 1995-06-28 | |
| PCT/US1996/011178 WO1997001571A1 (en) | 1995-06-28 | 1996-06-28 | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442373T1 true ATE442373T1 (de) | 2009-09-15 |
Family
ID=21692156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96924334T ATE442373T1 (de) | 1995-06-28 | 1996-06-28 | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US6262025B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0861261B9 (cg-RX-API-DMAC7.html) |
| JP (3) | JPH11508771A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE442373T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU723939B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2226087C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69638023D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0861261T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2334953T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT861261E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997001571A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| EP0861261B9 (en) | 1995-06-28 | 2010-02-24 | Imperial Cancer Research Technology Limited | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US6337387B1 (en) | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
| ATE342358T1 (de) | 1997-04-04 | 2006-11-15 | Millennium Biotherapeutics Inc | Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| ES2284205T3 (es) * | 1997-05-14 | 2007-11-01 | Asahi Kasei Kabushiki Kaisha | Nuevo inhibidor de diferenciacion. |
| AU737132B2 (en) * | 1997-06-18 | 2001-08-09 | Zymogenetics Inc. | Mammalian neuro-growth factor like protein |
| US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| WO2000002897A2 (en) * | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
| EP1100899A2 (en) * | 1998-07-27 | 2001-05-23 | Amgen Inc. | Delta-related polypeptides |
| AU6053899A (en) * | 1998-09-18 | 2000-04-10 | Nuvelo, Inc. | Methods and compositions relating to egf-repeat-containing polypeptides |
| EP1518930B1 (en) * | 1998-10-13 | 2007-05-30 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US20080194022A1 (en) * | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| AU2001288628A1 (en) * | 2000-08-31 | 2002-03-13 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
| GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
| WO2003011317A1 (en) * | 2001-07-25 | 2003-02-13 | Lorantis Limited | Modulators of notch signalling for use in immunotherapy |
| JP2005526701A (ja) * | 2001-11-14 | 2005-09-08 | ロランティス リミテッド | 内科療法 |
| WO2004024764A1 (en) * | 2002-09-10 | 2004-03-25 | Lorantis Limited | Pharmaceutical composition and medical treatments comprising notch ligand proteins |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
| GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
| WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| EP1654383A1 (en) * | 2003-08-08 | 2006-05-10 | Licentia, Ltd. | Materials and methods for colorectal cancer screening, diagnosis, and therapy |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| JP2009507796A (ja) * | 2005-09-01 | 2009-02-26 | バスジーン セラピューティクス, インコーポレイテッド | デルタ様リガンド4のモジュレーターの利用及び同定方法 |
| US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| ES2547421T3 (es) | 2005-10-31 | 2015-10-06 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para diagnosticar y tratar el cáncer |
| WO2007053648A2 (en) | 2005-10-31 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| HRP20160082T1 (hr) * | 2006-09-29 | 2016-02-26 | Oncomed Pharmaceuticals, Inc. | Sastavi i postupci za dijagnosticiranje i lijeäśenje raka |
| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| US8148147B2 (en) * | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| KR101711672B1 (ko) | 2008-09-26 | 2017-03-03 | 온코메드 파마슈티칼스, 인크. | 프리즐드 결합 작용제 및 그의 용도 |
| DK2488204T3 (en) | 2009-10-16 | 2016-06-06 | Oncomed Pharm Inc | Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents |
| EP2506875A4 (en) * | 2009-12-01 | 2013-11-27 | Oncomed Pharm Inc | METHOD FOR THE TREATMENT OF TUMORS WITH K-RAS MUTATIONS |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| EP2555782A1 (en) | 2010-04-09 | 2013-02-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| JP2013523842A (ja) | 2010-04-09 | 2013-06-17 | フレッド ハッチンソン キャンサー リサーチ センター | 造血機能を提供するための組成物および方法 |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| SI3485903T1 (sl) | 2011-09-23 | 2023-02-28 | Mereo Biopharma 5, Inc. | Sredstva, ki vežejo VEGF/DLL4, in njihove uporabe |
| HK1203081A1 (en) | 2011-12-08 | 2015-10-16 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| CA2868747A1 (en) * | 2012-03-29 | 2013-10-03 | Robert J. Fleming | Methods and compositions for modulating notch activity |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| CA2889638A1 (en) | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
| AU2014205662B2 (en) | 2013-01-08 | 2019-09-05 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| WO2014121196A1 (en) | 2013-02-04 | 2014-08-07 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| NZ758715A (en) | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| CA2966042A1 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| EP3247808B1 (en) | 2015-01-21 | 2021-05-05 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US6004924A (en) * | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| WO1994007522A1 (en) | 1992-09-30 | 1994-04-14 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
| US5750652A (en) | 1994-01-21 | 1998-05-12 | Yale University | Deltex proteins |
| EP0861261B9 (en) * | 1995-06-28 | 2010-02-24 | Imperial Cancer Research Technology Limited | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| CA2238404A1 (en) | 1995-11-22 | 1997-05-29 | Yale University | Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions |
| WO1997045143A1 (en) | 1996-05-31 | 1997-12-04 | The National American Red Cross | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| CA2268751A1 (en) | 1996-10-21 | 1998-04-30 | Hsc Research And Development Limited Partnership | Fringe proteins and notch signalling |
| DE69733695T2 (de) | 1996-11-07 | 2006-05-18 | Lorantis Ltd. | Notch-liganden zur verwendung in der immuntherapie |
| US20020010137A1 (en) * | 1997-09-18 | 2002-01-24 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| ATE342358T1 (de) | 1997-04-04 | 2006-11-15 | Millennium Biotherapeutics Inc | Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| ES2284205T3 (es) | 1997-05-14 | 2007-11-01 | Asahi Kasei Kabushiki Kaisha | Nuevo inhibidor de diferenciacion. |
| US6436650B1 (en) * | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| TW406393B (en) * | 1997-12-01 | 2000-09-21 | United Microelectronics Corp | Method of manufacturing dielectrics and the inner-lining |
| WO2000002897A2 (en) | 1998-07-13 | 2000-01-20 | Yale University | Delta cleavage products and methods based thereon |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| US7399633B2 (en) | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| US20070003893A1 (en) * | 2005-06-30 | 2007-01-04 | Radek Bures | Combination lighter and breath freshener dispenser |
-
1996
- 1996-06-28 EP EP96924334A patent/EP0861261B9/en not_active Expired - Lifetime
- 1996-06-28 ES ES96924334T patent/ES2334953T3/es not_active Expired - Lifetime
- 1996-06-28 CA CA2226087A patent/CA2226087C/en not_active Expired - Lifetime
- 1996-06-28 AT AT96924334T patent/ATE442373T1/de active
- 1996-06-28 PT PT96924334T patent/PT861261E/pt unknown
- 1996-06-28 JP JP9504614A patent/JPH11508771A/ja not_active Withdrawn
- 1996-06-28 DE DE69638023T patent/DE69638023D1/de not_active Expired - Lifetime
- 1996-06-28 US US08/981,392 patent/US6262025B1/en not_active Expired - Lifetime
- 1996-06-28 WO PCT/US1996/011178 patent/WO1997001571A1/en not_active Ceased
- 1996-06-28 AU AU64817/96A patent/AU723939B2/en not_active Expired
- 1996-06-28 DK DK96924334T patent/DK0861261T3/da active
-
2001
- 2001-02-15 US US09/783,931 patent/US7118890B2/en not_active Expired - Fee Related
- 2001-07-17 US US09/908,322 patent/US6783956B2/en not_active Expired - Fee Related
-
2006
- 2006-07-24 US US11/492,497 patent/US7928071B2/en not_active Expired - Fee Related
- 2006-10-10 US US11/546,583 patent/US8415303B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 JP JP2008179448A patent/JP2009039101A/ja not_active Withdrawn
-
2011
- 2011-10-04 JP JP2011220536A patent/JP2012070735A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030073620A1 (en) | 2003-04-17 |
| DK0861261T3 (da) | 2009-12-14 |
| AU723939B2 (en) | 2000-09-07 |
| EP0861261A1 (en) | 1998-09-02 |
| PT861261E (pt) | 2009-12-16 |
| DE69638023D1 (de) | 2009-10-22 |
| US20070134239A1 (en) | 2007-06-14 |
| WO1997001571A1 (en) | 1997-01-16 |
| JP2012070735A (ja) | 2012-04-12 |
| CA2226087A1 (en) | 1997-01-16 |
| EP0861261B1 (en) | 2009-09-09 |
| JPH11508771A (ja) | 1999-08-03 |
| JP2009039101A (ja) | 2009-02-26 |
| US20020107194A1 (en) | 2002-08-08 |
| AU6481796A (en) | 1997-01-30 |
| ES2334953T3 (es) | 2010-03-17 |
| US8415303B2 (en) | 2013-04-09 |
| US7118890B2 (en) | 2006-10-10 |
| US7928071B2 (en) | 2011-04-19 |
| US6783956B2 (en) | 2004-08-31 |
| EP0861261B9 (en) | 2010-02-24 |
| US6262025B1 (en) | 2001-07-17 |
| CA2226087C (en) | 2012-01-31 |
| EP0861261A4 (en) | 2001-08-29 |
| US20070082846A1 (en) | 2007-04-12 |
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