DE3584775D1 - Zusammensetzung zur behandlung von an haemophilia-a-inhibitor leidenden kranken. - Google Patents
Zusammensetzung zur behandlung von an haemophilia-a-inhibitor leidenden kranken.Info
- Publication number
- DE3584775D1 DE3584775D1 DE8585905784T DE3584775T DE3584775D1 DE 3584775 D1 DE3584775 D1 DE 3584775D1 DE 8585905784 T DE8585905784 T DE 8585905784T DE 3584775 T DE3584775 T DE 3584775T DE 3584775 D1 DE3584775 D1 DE 3584775D1
- Authority
- DE
- Germany
- Prior art keywords
- viii
- inhibitor
- pct
- cag
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003112 inhibitor Substances 0.000 title abstract 6
- 201000003542 Factor VIII deficiency Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 4
- 108010054218 Factor VIII Proteins 0.000 abstract 3
- 102000001690 Factor VIII Human genes 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 229960000301 factor viii Drugs 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102100026735 Coagulation factor VIII Human genes 0.000 abstract 2
- 208000009292 Hemophilia A Diseases 0.000 abstract 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 238000001962 electrophoresis Methods 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 230000006058 immune tolerance Effects 0.000 abstract 1
- 239000003547 immunosorbent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000002947 procoagulating effect Effects 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK525384A DK525384D0 (da) | 1984-11-05 | 1984-11-05 | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
| PCT/DK1985/000105 WO1986002838A1 (en) | 1984-11-05 | 1985-11-05 | A preparation for the treatment of hemophilia a inhibitor patients and a process for producing such a preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3584775D1 true DE3584775D1 (de) | 1992-01-09 |
Family
ID=8140859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585905784T Expired - Fee Related DE3584775D1 (de) | 1984-11-05 | 1985-11-05 | Zusammensetzung zur behandlung von an haemophilia-a-inhibitor leidenden kranken. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4831119A (de) |
| EP (1) | EP0201574B1 (de) |
| JP (1) | JPH0713026B2 (de) |
| AT (1) | ATE69727T1 (de) |
| AU (1) | AU599310B2 (de) |
| CA (1) | CA1269042A (de) |
| DE (1) | DE3584775D1 (de) |
| DK (1) | DK525384D0 (de) |
| ES (1) | ES8701230A1 (de) |
| IL (1) | IL76929A (de) |
| WO (1) | WO1986002838A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4508709A (en) * | 1983-12-05 | 1985-04-02 | Armour Pharmaceutical Company | Process for purifying factor VIII:C |
| EP0251843A1 (de) * | 1986-06-06 | 1988-01-07 | Transgene S.A. | Verfahren zur Herstellung von Faktor VIII aus Säugerzellen |
| AU2473388A (en) * | 1987-11-16 | 1989-06-22 | Scripps Clinic And Research Foundation | Treatment of factor viii inhibitors |
| WO1990015992A1 (en) * | 1989-06-15 | 1990-12-27 | Smith William I Jr | Method and apparatus for inactivating infectious agents in and resisting coagulation of biological fluids |
| DK0436717T3 (da) * | 1989-08-02 | 2003-05-05 | Mitra Medical Technology Ab | System til anvendelse ved en fremgangsmåde til terapeutisk eller diagnostisk behandling |
| DK162233C (da) * | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
| IT1256622B (it) * | 1992-12-04 | 1995-12-12 | Sclavo Spa | Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale. |
| WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
| US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| JP2004517950A (ja) * | 2001-02-05 | 2004-06-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第ｖｉｉ因子ポリペプチド及び第ｖｉｉｉ因子ポリペプチドの組合された使用 |
| LT1596887T (lt) * | 2003-02-26 | 2022-04-25 | Nektar Therapeutics | Polimero-faktoriaus viii fragmento konjugatai |
| ES2333598T5 (es) * | 2003-05-06 | 2013-09-04 | Biogen Idec Hemophilia Inc | Proteinas quimericas del factor de coagulacion fc para tratar la hemofilia. |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| WO2006003183A1 (de) * | 2004-07-02 | 2006-01-12 | Alois Jungbauer | Peptide zur blockierung von fviii-inhibitoren |
| TWI683666B (zh) | 2013-03-15 | 2020-02-01 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE448945B (sv) * | 1979-12-20 | 1987-03-30 | Blombaeck E G B | Forfarande for rening och /eller koncentrering av faktor viii-komplexet |
| US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| AU555305B2 (en) * | 1982-09-29 | 1986-09-18 | Bayer Corporation | Antihemophilic factor concentrate |
| US4406886A (en) * | 1983-01-14 | 1983-09-27 | University Patents, Inc. | Purification of antihemophilia factor VIII by precipitation with zinc ions |
| EP0148843B2 (de) * | 1983-03-21 | 1994-05-04 | Novo Nordisk A/S | Antihämophilie-faktor-viii-konzentrat und dessen herstellungsverfahren |
| US4649132A (en) * | 1983-03-31 | 1987-03-10 | Scripps Clinic And Research Foundation | Treatment of Factor VIII inhibitors |
| GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
| FI852866L (fi) * | 1984-07-27 | 1986-01-28 | Meloy Lab | Rekombinantfaktor viii-r. |
-
1984
- 1984-11-05 DK DK525384A patent/DK525384D0/da unknown
-
1985
- 1985-11-04 CA CA000494555A patent/CA1269042A/en not_active Expired - Fee Related
- 1985-11-04 IL IL76929A patent/IL76929A/xx not_active IP Right Cessation
- 1985-11-05 ES ES549115A patent/ES8701230A1/es not_active Expired
- 1985-11-05 AU AU50926/85A patent/AU599310B2/en not_active Ceased
- 1985-11-05 EP EP85905784A patent/EP0201574B1/de not_active Expired - Lifetime
- 1985-11-05 WO PCT/DK1985/000105 patent/WO1986002838A1/en active IP Right Grant
- 1985-11-05 JP JP60505194A patent/JPH0713026B2/ja not_active Expired - Fee Related
- 1985-11-05 DE DE8585905784T patent/DE3584775D1/de not_active Expired - Fee Related
- 1985-11-05 US US06/881,687 patent/US4831119A/en not_active Expired - Lifetime
- 1985-11-05 AT AT85905784T patent/ATE69727T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK525384D0 (da) | 1984-11-05 |
| IL76929A (en) | 1990-07-26 |
| JPH0713026B2 (ja) | 1995-02-15 |
| IL76929A0 (en) | 1986-04-29 |
| JPS62501006A (ja) | 1987-04-23 |
| ES549115A0 (es) | 1986-12-01 |
| WO1986002838A1 (en) | 1986-05-22 |
| EP0201574A1 (de) | 1986-11-20 |
| ES8701230A1 (es) | 1986-12-01 |
| US4831119A (en) | 1989-05-16 |
| EP0201574B1 (de) | 1991-11-27 |
| AU5092685A (en) | 1986-06-03 |
| ATE69727T1 (de) | 1991-12-15 |
| CA1269042A (en) | 1990-05-15 |
| AU599310B2 (en) | 1990-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |