ATE441627T1 - Verfahren zur herstellung von valsartan - Google Patents
Verfahren zur herstellung von valsartanInfo
- Publication number
- ATE441627T1 ATE441627T1 AT06832282T AT06832282T ATE441627T1 AT E441627 T1 ATE441627 T1 AT E441627T1 AT 06832282 T AT06832282 T AT 06832282T AT 06832282 T AT06832282 T AT 06832282T AT E441627 T1 ATE441627 T1 AT E441627T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- valsartan
- relates
- compound
- novel
- Prior art date
Links
- 239000004072 C09CA03 - Valsartan Substances 0.000 title abstract 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title abstract 3
- 229960004699 valsartan Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 organic acid salt Chemical class 0.000 abstract 2
- FLJGWVVZJRATEU-UMSFTDKQSA-N (2S)-3-methyl-2-[pentanoyl-[[4-[2-[5-(3-pyrrol-2-ylidenepyrrol-2-yl)-1H-pyrrol-2-yl]phenyl]phenyl]methyl]amino]butanoic acid Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=CC=C(C=2C(C=CN=2)=C2N=CC=C2)N1 FLJGWVVZJRATEU-UMSFTDKQSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN992MU2005 | 2005-08-22 | ||
| PCT/IN2006/000220 WO2007032019A2 (en) | 2005-08-22 | 2006-06-29 | Process for preparing valsartan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441627T1 true ATE441627T1 (de) | 2009-09-15 |
Family
ID=37420060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06832282T ATE441627T1 (de) | 2005-08-22 | 2006-06-29 | Verfahren zur herstellung von valsartan |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7741507B2 (enExample) |
| EP (1) | EP1926705B3 (enExample) |
| JP (1) | JP2009504800A (enExample) |
| KR (1) | KR20080039510A (enExample) |
| AT (1) | ATE441627T1 (enExample) |
| BR (1) | BRPI0614836A2 (enExample) |
| CA (1) | CA2619955A1 (enExample) |
| DE (1) | DE602006008962D1 (enExample) |
| ES (1) | ES2333169T3 (enExample) |
| WO (1) | WO2007032019A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2057132A2 (en) * | 2006-07-03 | 2009-05-13 | Aurobindo Pharma Limited | Process for the preparation of the angiotensin ii antagonist valsartan |
| US8288561B2 (en) | 2007-05-07 | 2012-10-16 | Cipla Limited | Process for preparing valsartan |
| JP2010526126A (ja) * | 2007-05-07 | 2010-07-29 | シプラ・リミテッド | バルサルタンの製造方法 |
| US7943794B2 (en) * | 2008-02-13 | 2011-05-17 | Ranbaxy Laboratories Limited | Processes for the preparation of intermediates of valsartan |
| US8492577B2 (en) | 2008-04-07 | 2013-07-23 | Hetero Research Foundation | Process for preparation of valsartan intermediate |
| KR101009404B1 (ko) * | 2008-04-30 | 2011-01-19 | 켐젠주식회사 | (에스)-엔-(1-카르복시-2-메틸-프로-1-필)-엔-펜타노일-엔-[2'-(1에이취-테트라졸-5-일)비페닐-4-일-메틸]아민화합물의 고순도 제조방법 |
| KR101012135B1 (ko) * | 2008-12-18 | 2011-02-07 | 주식회사 대희화학 | 발사르탄 메틸 에스테르의 제조방법 |
| EP2316821A1 (en) * | 2009-10-27 | 2011-05-04 | Novartis AG | Process for the manufacture of organic compounds |
| US8981109B2 (en) * | 2010-07-02 | 2015-03-17 | Aurobindo Pharma Ltd | Process for the preparation of valsartan |
| CN102417486B (zh) * | 2012-01-04 | 2013-11-27 | 合肥工业大学 | 一种缬沙坦的合成方法 |
| CN105001173A (zh) * | 2015-06-30 | 2015-10-28 | 浙江天顺生物科技有限公司 | 一种lz969的制备方法 |
| CN112778159A (zh) * | 2021-02-19 | 2021-05-11 | 安徽云帆药业有限公司 | 一种缬沙坦中间体的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97219A (en) * | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them |
| ZA991706B (en) * | 1998-03-04 | 2000-10-03 | Takeda Chemical Industries Ltd | Sustained-release preparation for Aii Antagonist, production and use thereof. |
| JPH11322697A (ja) * | 1998-05-12 | 1999-11-24 | Sumika Fine Chemicals Co Ltd | Ｎ−〔（２’−シアノビフェニル−４−イル）メチル〕−ｌ−バリンベンジルエステルの製造法および該化合物の新規塩 |
| US20030068374A1 (en) * | 2000-02-21 | 2003-04-10 | Shigeru Kamei | Sustained release preparations of physiologically active compound hardly soluble in water and production process and use of the same |
| WO2005049588A1 (en) * | 2003-11-21 | 2005-06-02 | Ranbaxy Laboratories Limited | Process for isolation of valsartan |
| WO2005049587A1 (en) * | 2003-11-21 | 2005-06-02 | Ranbaxy Laboratories Limited | Process for preparation of biphenyl tetrazole |
| US7659406B2 (en) * | 2005-01-03 | 2010-02-09 | Dr. Reddy's Laboratories Limited | Process for preparing valsartan |
| EP1714963A1 (en) * | 2005-04-19 | 2006-10-25 | IPCA Laboratories Limited | Process for the Preparation of Valsartan and its Intermediates |
-
2006
- 2006-06-29 EP EP06832282A patent/EP1926705B3/en not_active Not-in-force
- 2006-06-29 CA CA002619955A patent/CA2619955A1/en not_active Abandoned
- 2006-06-29 DE DE602006008962T patent/DE602006008962D1/de active Active
- 2006-06-29 ES ES06832282T patent/ES2333169T3/es active Active
- 2006-06-29 AT AT06832282T patent/ATE441627T1/de not_active IP Right Cessation
- 2006-06-29 KR KR1020087007098A patent/KR20080039510A/ko not_active Withdrawn
- 2006-06-29 BR BRPI0614836-0A patent/BRPI0614836A2/pt not_active IP Right Cessation
- 2006-06-29 WO PCT/IN2006/000220 patent/WO2007032019A2/en not_active Ceased
- 2006-06-29 JP JP2008527597A patent/JP2009504800A/ja active Pending
- 2006-07-24 US US11/491,638 patent/US7741507B2/en not_active Expired - Fee Related
-
2010
- 2010-06-15 US US12/815,950 patent/US7923567B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1926705A2 (en) | 2008-06-04 |
| CA2619955A1 (en) | 2007-03-22 |
| KR20080039510A (ko) | 2008-05-07 |
| WO2007032019B1 (en) | 2007-07-26 |
| US7741507B2 (en) | 2010-06-22 |
| EP1926705B1 (en) | 2009-09-02 |
| DE602006008962D1 (de) | 2010-07-08 |
| WO2007032019A2 (en) | 2007-03-22 |
| EP1926705B3 (en) | 2010-09-15 |
| US20060258878A1 (en) | 2006-11-16 |
| ES2333169T3 (es) | 2010-02-17 |
| WO2007032019A3 (en) | 2007-06-14 |
| US7923567B2 (en) | 2011-04-12 |
| JP2009504800A (ja) | 2009-02-05 |
| BRPI0614836A2 (pt) | 2012-12-04 |
| US20100249430A1 (en) | 2010-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200900817A1 (ru) | Способ получения фторметилзамещённых гетероциклических соединений | |
| MX2009003739A (es) | Derivados de hidrobenzamida como inhibidores de hsp90. | |
| NZ600119A (en) | Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives | |
| MA29464B1 (fr) | Methode de preparation d'acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues | |
| PT2428519E (pt) | Processo para preparação de 17-o-vinil-triflatos como intermediários | |
| ATE441627T1 (de) | Verfahren zur herstellung von valsartan | |
| EA201170057A1 (ru) | Способ получения замещенных 2-аминотиазолонов | |
| NO20082005L (no) | Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon | |
| ATE532516T1 (de) | Verfahren zur synthese von glyt-1-hemmern | |
| DE502005008867D1 (de) | Verfahren zur herstellung von 2,5-dimethylphenylessigsäure | |
| EA200870038A1 (ru) | Способ получения аминов | |
| TW200635905A (en) | Processes for producing 4-aminoquinazolines | |
| ATE555093T1 (de) | Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung | |
| BRPI0516192A (pt) | composto, e, método para a preparação de um composto | |
| DE602004014822D1 (de) | Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol | |
| MEP1708A (xx) | Postupak proizvodnje thip-a | |
| DE602004008486D1 (de) | Verfahren zur herstellung von (1s,4r)-cis-4-ä2-amino-6-chlor-9h-purin-9-ylü-2-cyclopenten-1-methanol | |
| ATE478040T1 (de) | Verfahren zur herstellung von kontrastmitteln | |
| EA201001270A1 (ru) | Новый способ получения сульфонилпирролов в качестве ингибиторов гистондезацетилаз (hdac) | |
| DE602004030091D1 (de) | Verfahren zur reduktiven deshalogenierung | |
| DE602004020050D1 (de) | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte | |
| ATE549315T1 (de) | Verfahren zur herstellung von kristallinem perindopril | |
| ATE424397T1 (de) | Verfahren zur herstellung von losartanderivaten durch chlorierung und reduktion der entsprechenden 1h-imidazol-5-carbaldehyde | |
| ATE473966T1 (de) | Verfahren zur herstellung eines carbonsäureamidderivats | |
| EA200501135A1 (ru) | Способы получения алкалоидов хиназолина |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |