ATE437359T1 - Verwendung von temperatur- und strömungsprofilen bei analytischen prozessen auf gradientenelutionsbasis - Google Patents

Verwendung von temperatur- und strömungsprofilen bei analytischen prozessen auf gradientenelutionsbasis

Info

Publication number
ATE437359T1
ATE437359T1 AT03777995T AT03777995T ATE437359T1 AT E437359 T1 ATE437359 T1 AT E437359T1 AT 03777995 T AT03777995 T AT 03777995T AT 03777995 T AT03777995 T AT 03777995T AT E437359 T1 ATE437359 T1 AT E437359T1
Authority
AT
Austria
Prior art keywords
temperature
matrix
control device
interface
flow
Prior art date
Application number
AT03777995T
Other languages
English (en)
Inventor
Terry Sheehan
Original Assignee
Varian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Inc filed Critical Varian Inc
Application granted granted Critical
Publication of ATE437359T1 publication Critical patent/ATE437359T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
AT03777995T 2002-10-30 2003-10-29 Verwendung von temperatur- und strömungsprofilen bei analytischen prozessen auf gradientenelutionsbasis ATE437359T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42246502P 2002-10-30 2002-10-30
PCT/US2003/034442 WO2004042384A1 (en) 2002-10-30 2003-10-29 Use of temperature and flow profiles in gradient elution based analytical process

Publications (1)

Publication Number Publication Date
ATE437359T1 true ATE437359T1 (de) 2009-08-15

Family

ID=32312512

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03777995T ATE437359T1 (de) 2002-10-30 2003-10-29 Verwendung von temperatur- und strömungsprofilen bei analytischen prozessen auf gradientenelutionsbasis

Country Status (8)

Country Link
US (1) US7547555B2 (de)
EP (1) EP1561102B1 (de)
JP (1) JP4515265B2 (de)
AT (1) ATE437359T1 (de)
AU (1) AU2003286782A1 (de)
CA (1) CA2503069A1 (de)
DE (1) DE60328511D1 (de)
WO (1) WO2004042384A1 (de)

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US7863561B2 (en) * 2005-06-24 2011-01-04 Waters Technologies Corporation Mass-spectrometer interface housing
WO2009029231A2 (en) 2007-08-24 2009-03-05 Millipore Corporation Method of detecting filter extractables in biopharmaceutical products by liquid chromatography-mass spectrometry
ES2436744T3 (es) 2007-08-24 2014-01-07 Emd Millipore Corporation Sistema para derivar un eluyente de cromatografía de líquidos
CN102279236A (zh) * 2010-06-08 2011-12-14 江苏天瑞仪器股份有限公司 色谱质谱联用仪
US20140166875A1 (en) 2010-09-02 2014-06-19 Wayne State University Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
EP2612345B1 (de) * 2010-09-02 2020-04-08 University of the Sciences in Philadelphia System und verfahren zur ionisation von molekülen für die massenspektrometrie und ionenmobilitätsspektrometrie
US8853621B2 (en) * 2010-10-25 2014-10-07 Wayne State University Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum
US8410434B1 (en) * 2011-09-16 2013-04-02 Science & Engineering Services, Inc. Thermo-stabilized nano- and micro- flow LC/ESI-MS interface and a method thereof
US10287180B1 (en) * 2015-01-05 2019-05-14 Sutro Connect Inc. Water monitoring device with replaceable reagent cartridge
CN110446921A (zh) * 2017-03-16 2019-11-12 株式会社岛津制作所 带电粒子的供给控制方法和装置
US11764049B2 (en) * 2020-04-14 2023-09-19 Waters Technologies Corporation Coaxial introduction of calibrant in a flow path with analyte to an ion source
US20230015697A1 (en) * 2021-07-13 2023-01-19 Citrix Systems, Inc. Application programming interface (api) authorization

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59135467U (ja) * 1983-02-28 1984-09-10 日本電子株式会社 液体クロマトグラフ質量分析装置
US4814612A (en) * 1983-08-30 1989-03-21 Research Corporation Method and means for vaporizing liquids for detection or analysis
US4958529A (en) * 1989-11-22 1990-09-25 Vestec Corporation Interface for coupling liquid chromatography to solid or gas phase detectors
JPH0712797A (ja) * 1993-06-24 1995-01-17 Hitachi Ltd 質量分析装置
JP3087548B2 (ja) * 1993-12-09 2000-09-11 株式会社日立製作所 液体クロマトグラフ結合型質量分析装置
JP3379510B2 (ja) * 1993-12-09 2003-02-24 株式会社日立製作所 液体クロマトグラフ結合型質量分析装置
US5412208A (en) * 1994-01-13 1995-05-02 Mds Health Group Limited Ion spray with intersecting flow
JPH0943202A (ja) * 1995-07-27 1997-02-14 Shimadzu Corp 液体クロマトグラフ質量分析装置
JPH1078421A (ja) * 1996-09-03 1998-03-24 Hitachi Ltd 液体クロマトグラフ質量分析計
JPH11326302A (ja) * 1998-05-13 1999-11-26 Shimadzu Corp 液体クロマトグラフ質量分析装置
JP2000055880A (ja) * 1998-08-06 2000-02-25 Shimadzu Corp 液体クロマトグラフ質量分析装置
JP4023056B2 (ja) * 1999-12-22 2007-12-19 株式会社島津製作所 液体クロマトグラフ質量分析計
MXPA02007665A (es) * 2000-02-08 2004-08-23 Univ Michigan Trazado de despliegue diferencial de proteinas.
WO2001090739A1 (en) * 2000-05-23 2001-11-29 Discovery Partners International, Inc. High-throughput purification process
JP2002015697A (ja) * 2000-06-30 2002-01-18 Jeol Ltd エレクトロスプレー・イオン源
US6484560B1 (en) * 2000-11-07 2002-11-26 Agilent Technologies, Inc. In Situ concentration of an analyte
JP3422992B2 (ja) * 2001-07-23 2003-07-07 株式会社日立製作所 質量分析計

Also Published As

Publication number Publication date
EP1561102A1 (de) 2005-08-10
DE60328511D1 (de) 2009-09-03
US7547555B2 (en) 2009-06-16
CA2503069A1 (en) 2004-05-21
JP2006504972A (ja) 2006-02-09
JP4515265B2 (ja) 2010-07-28
US20070048187A1 (en) 2007-03-01
WO2004042384A1 (en) 2004-05-21
EP1561102B1 (de) 2009-07-22
AU2003286782A1 (en) 2004-06-07

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