ATE429930T1 - Verfahren zur förderung des nukleinsäuretransfers - Google Patents
Verfahren zur förderung des nukleinsäuretransfersInfo
- Publication number
- ATE429930T1 ATE429930T1 AT02741206T AT02741206T ATE429930T1 AT E429930 T1 ATE429930 T1 AT E429930T1 AT 02741206 T AT02741206 T AT 02741206T AT 02741206 T AT02741206 T AT 02741206T AT E429930 T1 ATE429930 T1 AT E429930T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- cells
- complex particles
- gene
- protein
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 13
- 102000039446 nucleic acids Human genes 0.000 title abstract 13
- 150000007523 nucleic acids Chemical class 0.000 title abstract 13
- 238000000034 method Methods 0.000 title abstract 6
- 230000001737 promoting effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 9
- 239000002245 particle Substances 0.000 abstract 8
- 102000008186 Collagen Human genes 0.000 abstract 4
- 108010035532 Collagen Proteins 0.000 abstract 4
- 229920001436 collagen Polymers 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 238000012258 culturing Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000007790 solid phase Substances 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001186320 | 2001-06-20 | ||
| JP2001278293 | 2001-09-13 | ||
| PCT/JP2002/006137 WO2003000297A1 (fr) | 2001-06-20 | 2002-06-20 | Procede facilitant le transfert d'acides nucleiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429930T1 true ATE429930T1 (de) | 2009-05-15 |
Family
ID=26617260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02741206T ATE429930T1 (de) | 2001-06-20 | 2002-06-20 | Verfahren zur förderung des nukleinsäuretransfers |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8742091B2 (de) |
| EP (1) | EP1407787B1 (de) |
| JP (1) | JP4081436B2 (de) |
| KR (1) | KR100888566B1 (de) |
| CN (1) | CN1313158C (de) |
| AT (1) | ATE429930T1 (de) |
| CA (1) | CA2451603C (de) |
| DE (1) | DE60232149D1 (de) |
| DK (1) | DK1407787T3 (de) |
| ES (1) | ES2324525T3 (de) |
| PT (1) | PT1407787E (de) |
| WO (1) | WO2003000297A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1295611T3 (da) * | 2000-06-20 | 2010-10-04 | Dainippon Sumitomo Pharma Co | Oligonukleotid-transformerende forbindelser |
| JP4081436B2 (ja) | 2001-06-20 | 2008-04-23 | 大日本住友製薬株式会社 | 核酸導入を促進させる方法 |
| JP4954550B2 (ja) * | 2003-12-19 | 2012-06-20 | 大日本住友製薬株式会社 | 新規な核酸導入法 |
| EP1715052A4 (de) * | 2004-01-29 | 2007-10-03 | Nat Inst Of Advanced Ind Scien | Zusammensetzung und verfahren zur erhöhung der gentransfereffizienz |
| JP2007267602A (ja) * | 2004-06-25 | 2007-10-18 | National Institute Of Advanced Industrial & Technology | 固相上で細胞に核酸を導入し、かつ、この細胞を分化誘導させるための方法および組成物 |
| JP4585242B2 (ja) * | 2004-06-29 | 2010-11-24 | 株式会社高研 | 核酸導入用セルトランスフェクションアレイ |
| US20090062184A1 (en) * | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
| US7838502B2 (en) * | 2005-05-06 | 2010-11-23 | University Of Massachusetts Medical School | Compositions and methods to modulate H. influenzae pathogenesis |
| JPWO2006126600A1 (ja) * | 2005-05-25 | 2008-12-25 | 国立大学法人名古屋大学 | 血管閉塞性疾患用医薬組成物 |
| US8029990B2 (en) * | 2005-07-22 | 2011-10-04 | Koken Co., Ltd. | Cell transfection array for introduction of nucleic acid |
| WO2007107774A2 (en) * | 2006-03-22 | 2007-09-27 | Cartela R & D Ab | Integrin alpha-10 subunit as therapeutic target and diagnostic/prognostic marker for cancer |
| EP2127681A4 (de) * | 2007-02-16 | 2011-10-12 | Anges Mg Inc | Therapeutisches mittel gegen parodontalerkrankungen und alveolar-knochenverlust durch operation |
| JP5789927B2 (ja) * | 2010-07-30 | 2015-10-07 | Jnc株式会社 | 放射線照射コラーゲン様ペプチドを用いた核酸導入法 |
| WO2013102878A2 (en) | 2012-01-05 | 2013-07-11 | Department Of Biotechnology (Dbt) | Fat1 gene in cancer and inflammation |
| US12433937B2 (en) | 2019-08-30 | 2025-10-07 | University Of Florida Research Foundation, Inc. | Aptamer assemblies for protein crosslinking |
| WO2022120338A1 (en) * | 2020-12-03 | 2022-06-09 | University Of Florida Research Foundation, Inc. | Aptamer assemblies for protein crosslinking |
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|---|---|---|---|---|
| JPS5115094B2 (de) | 1972-11-01 | 1976-05-14 | ||
| JPH0712375B2 (ja) * | 1986-11-17 | 1995-02-15 | 株式会社高研 | 移植組成物及びその製造方法 |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| JPS6416581A (en) | 1987-07-09 | 1989-01-20 | Rikagaku Kenkyusho | Frozen animal cell and production thereof |
| JPH01157388A (ja) | 1987-12-11 | 1989-06-20 | Mitsubishi Heavy Ind Ltd | 形質転換方法 |
| US5078997A (en) | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
| US5614587A (en) | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| US5936035A (en) | 1988-11-21 | 1999-08-10 | Cohesion Technologies, Inc. | Biocompatible adhesive compositions |
| JP3187410B2 (ja) | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
| JP2789115B2 (ja) | 1989-09-07 | 1998-08-20 | 株式会社高研 | 可溶性コラーゲンパウダーを担体とする粒状医薬徐放剤の製造方法 |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| ES2104690T3 (es) | 1989-12-22 | 1997-10-16 | Applied Research Systems | Modificaciones de la expresion de genes endogenos con un elemento regulador por medio de recombinacion homologa. |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
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| FR2694895B1 (fr) * | 1992-08-20 | 1994-11-10 | Coletica | Procédé de fabrication de microparticules en émulsion par modification de la composition chimique de la phase dispersée après émulsification. |
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| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5583034A (en) * | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| US5844107A (en) | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
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| EP0844004B1 (de) | 1995-07-03 | 2007-09-12 | Koken Co., Ltd. | Atelocollagen enthaltende gen-zusammensetzungen |
| JP3867160B2 (ja) | 1995-07-03 | 2007-01-10 | 大日本住友製薬株式会社 | 遺伝子製剤 |
| US6998268B2 (en) | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
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| EP0904373A1 (de) * | 1996-03-14 | 1999-03-31 | The Immune Response Corporation | Zielgerichtete abgage von interferon-kodierenden genen |
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| JP2001335512A (ja) | 2000-05-23 | 2001-12-04 | Yamanouchi Pharmaceut Co Ltd | 遺伝子導入のための微粒子 |
| DK1295611T3 (da) | 2000-06-20 | 2010-10-04 | Dainippon Sumitomo Pharma Co | Oligonukleotid-transformerende forbindelser |
| JP2002325572A (ja) | 2000-12-25 | 2002-11-12 | Univ Osaka | 外来物質の導入方法 |
| JP4081436B2 (ja) | 2001-06-20 | 2008-04-23 | 大日本住友製薬株式会社 | 核酸導入を促進させる方法 |
| JP4022614B2 (ja) | 2002-03-25 | 2007-12-19 | 国立大学法人大阪大学 | 新規なバイオビーズの作製方法 |
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| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| US20060030534A1 (en) | 2002-09-04 | 2006-02-09 | Gabriele Dorn | Treatment of neurological disorders by dsrna administration |
| WO2004026343A1 (ja) | 2002-09-20 | 2004-04-01 | Sumitomo Phamaceuticals Co., Ltd. | 部位特異的遺伝子変換促進剤および遺伝子疾患治療剤 |
| KR20050083855A (ko) | 2002-11-01 | 2005-08-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | ＨＩＦ-1 알파의 ｓｉＲＮＡ 억제를 위한 조성물 및 방법 |
| WO2004065546A2 (en) | 2003-01-16 | 2004-08-05 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ICAM-1 |
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| EP1720893B1 (de) | 2004-02-26 | 2014-08-13 | Baylor Research Institute | Zusammensetzungen und verfahren zur systemischen behandlung von arthritis |
| KR101357016B1 (ko) | 2004-09-28 | 2014-02-03 | 쿠아크 파마수티칼스 인코퍼레이티드 | 탈모증, 급성신부전증 및 다른 질환의 치료를 위한올리고리보뉴클레오티드 및 그것의 사용방법 |
| AU2005297354A1 (en) | 2004-10-22 | 2006-04-27 | The Hospital For Sick Children | Modulation of neuroglia-derived BDNF in the treatment and prevention of pain |
| US7585848B2 (en) | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
| WO2007082899A1 (en) | 2006-01-17 | 2007-07-26 | Vib Vzw | Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration |
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| EP2546337A1 (de) | 2006-07-21 | 2013-01-16 | Silence Therapeutics AG | Einrichtung zur Verhinderung des Ausdrucks von Proteinkinase 3 |
| US7825101B2 (en) | 2006-08-30 | 2010-11-02 | The Board Of Trustees Of The University Of Illinois | Modulation of MLCK-L expression and uses thereof |
| EP2069501A2 (de) | 2006-10-02 | 2009-06-17 | Aprea Ab | Rna-interferenz gegen wrap53 zur behandlung hyperproliferativer erkrankungen |
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| JP2013512677A (ja) | 2009-12-04 | 2013-04-18 | オプコ オプサルミクス、エルエルシー | Ｖｅｇｆの阻害のための組成物および方法 |
-
2002
- 2002-06-20 JP JP2003506939A patent/JP4081436B2/ja not_active Expired - Lifetime
- 2002-06-20 CN CNB028164008A patent/CN1313158C/zh not_active Expired - Fee Related
- 2002-06-20 PT PT02741206T patent/PT1407787E/pt unknown
- 2002-06-20 US US10/481,511 patent/US8742091B2/en not_active Expired - Lifetime
- 2002-06-20 DK DK02741206T patent/DK1407787T3/da active
- 2002-06-20 WO PCT/JP2002/006137 patent/WO2003000297A1/ja not_active Ceased
- 2002-06-20 CA CA2451603A patent/CA2451603C/en not_active Expired - Fee Related
- 2002-06-20 DE DE60232149T patent/DE60232149D1/de not_active Expired - Lifetime
- 2002-06-20 KR KR1020037016627A patent/KR100888566B1/ko not_active Expired - Fee Related
- 2002-06-20 AT AT02741206T patent/ATE429930T1/de active
- 2002-06-20 EP EP02741206A patent/EP1407787B1/de not_active Expired - Lifetime
- 2002-06-20 ES ES02741206T patent/ES2324525T3/es not_active Expired - Lifetime
-
2009
- 2009-09-04 US US12/554,846 patent/US20100081202A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8742091B2 (en) | 2014-06-03 |
| EP1407787B1 (de) | 2009-04-29 |
| US20040266004A1 (en) | 2004-12-30 |
| EP1407787A4 (de) | 2006-02-08 |
| CA2451603A1 (en) | 2003-01-03 |
| PT1407787E (pt) | 2009-07-07 |
| KR100888566B1 (ko) | 2009-03-12 |
| CA2451603C (en) | 2012-07-10 |
| JPWO2003000297A1 (ja) | 2005-04-07 |
| US20100081202A1 (en) | 2010-04-01 |
| KR20040023622A (ko) | 2004-03-18 |
| CN1313158C (zh) | 2007-05-02 |
| DE60232149D1 (de) | 2009-06-10 |
| ES2324525T3 (es) | 2009-08-10 |
| WO2003000297A1 (fr) | 2003-01-03 |
| DK1407787T3 (da) | 2009-06-02 |
| CN1622831A (zh) | 2005-06-01 |
| EP1407787A1 (de) | 2004-04-14 |
| JP4081436B2 (ja) | 2008-04-23 |
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