ATE429930T1 - Verfahren zur förderung des nukleinsäuretransfers - Google Patents
Verfahren zur förderung des nukleinsäuretransfersInfo
- Publication number
- ATE429930T1 ATE429930T1 AT02741206T AT02741206T ATE429930T1 AT E429930 T1 ATE429930 T1 AT E429930T1 AT 02741206 T AT02741206 T AT 02741206T AT 02741206 T AT02741206 T AT 02741206T AT E429930 T1 ATE429930 T1 AT E429930T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- cells
- complex particles
- gene
- protein
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 13
- 102000039446 nucleic acids Human genes 0.000 title abstract 13
- 150000007523 nucleic acids Chemical class 0.000 title abstract 13
- 238000000034 method Methods 0.000 title abstract 6
- 230000001737 promoting effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 9
- 239000002245 particle Substances 0.000 abstract 8
- 102000008186 Collagen Human genes 0.000 abstract 4
- 108010035532 Collagen Proteins 0.000 abstract 4
- 229920001436 collagen Polymers 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 238000012258 culturing Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000007790 solid phase Substances 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001186320 | 2001-06-20 | ||
| JP2001278293 | 2001-09-13 | ||
| PCT/JP2002/006137 WO2003000297A1 (fr) | 2001-06-20 | 2002-06-20 | Procede facilitant le transfert d'acides nucleiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429930T1 true ATE429930T1 (de) | 2009-05-15 |
Family
ID=26617260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02741206T ATE429930T1 (de) | 2001-06-20 | 2002-06-20 | Verfahren zur förderung des nukleinsäuretransfers |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8742091B2 (de) |
| EP (1) | EP1407787B1 (de) |
| JP (1) | JP4081436B2 (de) |
| KR (1) | KR100888566B1 (de) |
| CN (1) | CN1313158C (de) |
| AT (1) | ATE429930T1 (de) |
| CA (1) | CA2451603C (de) |
| DE (1) | DE60232149D1 (de) |
| DK (1) | DK1407787T3 (de) |
| ES (1) | ES2324525T3 (de) |
| PT (1) | PT1407787E (de) |
| WO (1) | WO2003000297A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001264317A1 (en) * | 2000-06-20 | 2002-01-02 | Koken Co., Ltd. | Preparations for oligonucleotide transfer |
| EP1407787B1 (de) | 2001-06-20 | 2009-04-29 | Dainippon Sumitomo Pharma Co., Ltd. | Verfahren zur förderung des nukleinsäuretransfers |
| WO2005061717A1 (ja) * | 2003-12-19 | 2005-07-07 | Dainippon Sumitomo Pharma Co., Ltd. | 新規な核酸導入法 |
| EP1715052A4 (de) * | 2004-01-29 | 2007-10-03 | Nat Inst Of Advanced Ind Scien | Zusammensetzung und verfahren zur erhöhung der gentransfereffizienz |
| JP2007267602A (ja) * | 2004-06-25 | 2007-10-18 | National Institute Of Advanced Industrial & Technology | 固相上で細胞に核酸を導入し、かつ、この細胞を分化誘導させるための方法および組成物 |
| JP4585242B2 (ja) * | 2004-06-29 | 2010-11-24 | 株式会社高研 | 核酸導入用セルトランスフェクションアレイ |
| US20090062184A1 (en) * | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
| US7838502B2 (en) * | 2005-05-06 | 2010-11-23 | University Of Massachusetts Medical School | Compositions and methods to modulate H. influenzae pathogenesis |
| ES2405357T3 (es) * | 2005-05-25 | 2013-05-30 | Cellmid Limited | Composición farmacéutica para la vasculopatía oclusiva. |
| WO2007010620A1 (ja) | 2005-07-22 | 2007-01-25 | Koken Co., Ltd. | 核酸導入用セルトランスフェクションアレイ |
| WO2007107774A2 (en) * | 2006-03-22 | 2007-09-27 | Cartela R & D Ab | Integrin alpha-10 subunit as therapeutic target and diagnostic/prognostic marker for cancer |
| US20100105762A1 (en) * | 2007-02-16 | 2010-04-29 | Ryuichi Morishita | Therapeutic agent for periodontal disease and alveolar bone loss due to surgery |
| JP5789927B2 (ja) * | 2010-07-30 | 2015-10-07 | Jnc株式会社 | 放射線照射コラーゲン様ペプチドを用いた核酸導入法 |
| WO2013102878A2 (en) | 2012-01-05 | 2013-07-11 | Department Of Biotechnology (Dbt) | Fat1 gene in cancer and inflammation |
| WO2021041870A1 (en) * | 2019-08-30 | 2021-03-04 | University Of Florida Research Foundation | Aptamer assemblies for protein crosslinking |
| WO2022120338A1 (en) * | 2020-12-03 | 2022-06-09 | University Of Florida Research Foundation, Inc. | Aptamer assemblies for protein crosslinking |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5115094B2 (de) | 1972-11-01 | 1976-05-14 | ||
| JPH0712375B2 (ja) * | 1986-11-17 | 1995-02-15 | 株式会社高研 | 移植組成物及びその製造方法 |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| JPS6416581A (en) | 1987-07-09 | 1989-01-20 | Rikagaku Kenkyusho | Frozen animal cell and production thereof |
| JPH01157388A (ja) | 1987-12-11 | 1989-06-20 | Mitsubishi Heavy Ind Ltd | 形質転換方法 |
| US5078997A (en) | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
| US5614587A (en) | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| US5936035A (en) | 1988-11-21 | 1999-08-10 | Cohesion Technologies, Inc. | Biocompatible adhesive compositions |
| JP3187410B2 (ja) | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
| JP2789115B2 (ja) | 1989-09-07 | 1998-08-20 | 株式会社高研 | 可溶性コラーゲンパウダーを担体とする粒状医薬徐放剤の製造方法 |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| ES2151463T5 (es) | 1989-12-22 | 2012-10-29 | Merck Serono Sa | Constructos de ADN para la activación y la modificación de la expresión de genes endógenos |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| JP2666535B2 (ja) | 1990-08-07 | 1997-10-22 | 東洋紡績株式会社 | 大腸菌のコンピテントセル化緩衝液および大腸菌のコンピテントセル化方法 |
| FR2694895B1 (fr) * | 1992-08-20 | 1994-11-10 | Coletica | Procédé de fabrication de microparticules en émulsion par modification de la composition chimique de la phase dispersée après émulsification. |
| US5646042A (en) | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
| WO1994028014A2 (en) * | 1993-05-28 | 1994-12-08 | Chiron Corporation | Peptide inhibitors of urokinase receptor activity |
| AU7655194A (en) * | 1993-09-09 | 1995-03-27 | Schering Aktiengesellschaft | Active principles and gas containing microparticles |
| CA2140053C (en) | 1994-02-09 | 2000-04-04 | Joel S. Rosenblatt | Collagen-based injectable drug delivery system and its use |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5583034A (en) * | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| US5844107A (en) | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5563255A (en) * | 1994-05-31 | 1996-10-08 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
| JPH11505505A (ja) * | 1994-06-27 | 1999-05-21 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ターゲッティングされた遺伝子輸送システム |
| NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| GB9422495D0 (en) | 1994-11-08 | 1995-01-04 | Medical Res Council | DNA transfer method |
| WO2001074342A2 (en) | 2000-03-31 | 2001-10-11 | Trustees Of Boston University | Use of locally applied dna fragments |
| US6998268B2 (en) | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
| JP3867160B2 (ja) | 1995-07-03 | 2007-01-10 | 大日本住友製薬株式会社 | 遺伝子製剤 |
| IL122802A0 (en) | 1995-07-03 | 1998-08-16 | Koken Kk | Gene preparations |
| CA2235685A1 (en) | 1995-10-23 | 1997-05-01 | Hyal Pharmaceutical Australia Limited | Hyaluronic acid as dna carrier for gene therapy and vegf antisense dna to treat abnormal retinal vascularization |
| KR100353115B1 (ko) | 1995-11-13 | 2003-01-06 | 다카라츠죠 가부시키가이샤 | 레트로바이러스를사용한표적세포내로의유전자도입방법 |
| WO1997022371A1 (en) | 1995-12-18 | 1997-06-26 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
| WO1997033998A1 (en) * | 1996-03-14 | 1997-09-18 | The Immune Response Corporation | Targeted delivery of genes encoding interferon |
| US5874006A (en) * | 1996-10-31 | 1999-02-23 | Matrix Pharmaceutical, Inc. | Aseptic collagen concentration process |
| US6042820A (en) * | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| US6218112B1 (en) * | 1996-12-23 | 2001-04-17 | Cobra Therapeutics Limited | Optimization of gene delivery and gene delivery system |
| US6524613B1 (en) * | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| IT1293088B1 (it) | 1997-07-10 | 1999-02-11 | Isi Ist Sierovaccinogeno Ital | Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in |
| JPH11127843A (ja) | 1997-10-27 | 1999-05-18 | Sumitomo Bakelite Co Ltd | 培養用着色容器 |
| TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
| WO1999040771A2 (en) * | 1998-02-13 | 1999-08-19 | Selective Genetics, Inc. | Concurrent flow mixing for preparing compositions comprising gene therapy vectors |
| US7052875B1 (en) | 1998-05-22 | 2006-05-30 | Sumitomo Pharmaceutical Company, Limited | Stable gene preparations |
| JP3587438B2 (ja) | 1999-01-14 | 2004-11-10 | 住友ベークライト株式会社 | 培養細胞凍結用マルチウェルプレート |
| JP3557924B2 (ja) * | 1998-12-10 | 2004-08-25 | トヨタ自動車株式会社 | 電動機制御装置及び電動機制御方法 |
| TR199901199A2 (xx) | 1999-05-31 | 2001-09-21 | Kocagöz Tanil | Bakteri transformasyon kiti |
| JP2001199903A (ja) | 1999-11-09 | 2001-07-24 | Eizo Mori | 核酸含有複合体 |
| JP2001335512A (ja) | 2000-05-23 | 2001-12-04 | Yamanouchi Pharmaceut Co Ltd | 遺伝子導入のための微粒子 |
| AU2001264317A1 (en) | 2000-06-20 | 2002-01-02 | Koken Co., Ltd. | Preparations for oligonucleotide transfer |
| JP2002325572A (ja) | 2000-12-25 | 2002-11-12 | Univ Osaka | 外来物質の導入方法 |
| EP1407787B1 (de) | 2001-06-20 | 2009-04-29 | Dainippon Sumitomo Pharma Co., Ltd. | Verfahren zur förderung des nukleinsäuretransfers |
| JP4022614B2 (ja) | 2002-03-25 | 2007-12-19 | 国立大学法人大阪大学 | 新規なバイオビーズの作製方法 |
| ITMI20021444A1 (it) | 2002-07-01 | 2004-01-02 | Danieli Off Mecc | Tubo forma spire |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| EP1551424B1 (de) | 2002-09-04 | 2015-07-01 | Arrowhead Research Corporation | Behandlung von chronisch neuropathischen schmerzen durch verabreichung von dsrna |
| WO2004026343A1 (ja) | 2002-09-20 | 2004-04-01 | Sumitomo Phamaceuticals Co., Ltd. | 部位特異的遺伝子変換促進剤および遺伝子疾患治療剤 |
| NZ540779A (en) | 2002-11-01 | 2008-05-30 | Univ Pennsylvania | Compositions and methods for siRNA inhibition of HIF-1 alpha |
| JP2007524349A (ja) | 2003-01-16 | 2007-08-30 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | ＩＣＡＭ−１のｓｉＲＮＡ阻害のための組成物及び方法 |
| US8227434B1 (en) | 2003-11-04 | 2012-07-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Materials and methods for treating oncological disorders |
| EP1720893B1 (de) | 2004-02-26 | 2014-08-13 | Baylor Research Institute | Zusammensetzungen und verfahren zur systemischen behandlung von arthritis |
| AU2005288522B2 (en) | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| WO2006042396A1 (en) | 2004-10-22 | 2006-04-27 | Universite Laval | Modulation of neuroglia-derived bdnf in the treatment and prevention of pain |
| US7585848B2 (en) | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
| WO2007082899A1 (en) | 2006-01-17 | 2007-07-26 | Vib Vzw | Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration |
| EP2047864B1 (de) * | 2006-06-16 | 2017-04-05 | Taisho Pharmaceutical Co., Ltd. | Verwendung von rpn2-gen-expressionshemmer |
| KR101670085B1 (ko) | 2006-07-21 | 2016-10-28 | 사일런스 테라퓨틱스 게엠베하 | 단백질 키나아제 3의 발현을 억제하기 위한 수단 |
| US7825101B2 (en) | 2006-08-30 | 2010-11-02 | The Board Of Trustees Of The University Of Illinois | Modulation of MLCK-L expression and uses thereof |
| US7902167B2 (en) | 2006-10-02 | 2011-03-08 | Aprea Ab | Compounds and methods for down-regulating Wrap53 protein by RNA interference |
| US7812002B2 (en) | 2007-03-21 | 2010-10-12 | Quark Pharmaceuticals, Inc. | Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer |
| US8227444B2 (en) | 2009-12-04 | 2012-07-24 | Opko Ophthalmics, Llc | Compositions and methods for inhibition of VEGF |
-
2002
- 2002-06-20 EP EP02741206A patent/EP1407787B1/de not_active Expired - Lifetime
- 2002-06-20 DK DK02741206T patent/DK1407787T3/da active
- 2002-06-20 AT AT02741206T patent/ATE429930T1/de active
- 2002-06-20 KR KR1020037016627A patent/KR100888566B1/ko not_active Expired - Fee Related
- 2002-06-20 ES ES02741206T patent/ES2324525T3/es not_active Expired - Lifetime
- 2002-06-20 DE DE60232149T patent/DE60232149D1/de not_active Expired - Lifetime
- 2002-06-20 CN CNB028164008A patent/CN1313158C/zh not_active Expired - Fee Related
- 2002-06-20 PT PT02741206T patent/PT1407787E/pt unknown
- 2002-06-20 US US10/481,511 patent/US8742091B2/en not_active Expired - Lifetime
- 2002-06-20 JP JP2003506939A patent/JP4081436B2/ja not_active Expired - Lifetime
- 2002-06-20 WO PCT/JP2002/006137 patent/WO2003000297A1/ja not_active Ceased
- 2002-06-20 CA CA2451603A patent/CA2451603C/en not_active Expired - Fee Related
-
2009
- 2009-09-04 US US12/554,846 patent/US20100081202A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1407787A1 (de) | 2004-04-14 |
| CN1313158C (zh) | 2007-05-02 |
| CA2451603A1 (en) | 2003-01-03 |
| JP4081436B2 (ja) | 2008-04-23 |
| WO2003000297A1 (fr) | 2003-01-03 |
| DE60232149D1 (de) | 2009-06-10 |
| CA2451603C (en) | 2012-07-10 |
| US20100081202A1 (en) | 2010-04-01 |
| DK1407787T3 (da) | 2009-06-02 |
| US20040266004A1 (en) | 2004-12-30 |
| KR100888566B1 (ko) | 2009-03-12 |
| ES2324525T3 (es) | 2009-08-10 |
| PT1407787E (pt) | 2009-07-07 |
| EP1407787B1 (de) | 2009-04-29 |
| CN1622831A (zh) | 2005-06-01 |
| US8742091B2 (en) | 2014-06-03 |
| JPWO2003000297A1 (ja) | 2005-04-07 |
| KR20040023622A (ko) | 2004-03-18 |
| EP1407787A4 (de) | 2006-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60232149D1 (de) | Verfahren zur förderung des nukleinsäuretransfers | |
| Tezuka et al. | Identification of osteopontin in isolated rabbit osteoclasts | |
| JP6986103B2 (ja) | 高スループット単一細胞トランスクリプトームライブラリーならびにその作製方法および使用方法 | |
| Jafary et al. | Osteoblast differentiation on collagen scaffold with immobilized alkaline phosphatase | |
| CA2501280C (en) | Cell culture | |
| RU2688485C2 (ru) | Способы получения библиотек двухцепочечных днк и способы секвенирования для идентификации метилированных цитозинов | |
| Mademtzoglou et al. | Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells | |
| Satija et al. | Mesenchymal stem cells: molecular targets for tissue engineering | |
| Kriukienė et al. | 5-Hydroxymethylcytosine: the many faces of the sixth base of mammalian DNA | |
| AU2006306809B2 (en) | Methods of specifying mesodermal, endodermal and mesoendodermal cell fates | |
| US20170356039A1 (en) | Vesicular linker and uses thereof in nucleic acid library construction and sequencing | |
| Person et al. | Antisense oligonucleotide experiments elucidate the essential role of titin in sarcomerogenesis in adult rat cardiomyocytes in long-term culture | |
| Rood et al. | Genomic organization and chromosome localization of the human cathepsin K gene (CTSK) | |
| Hirst et al. | Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene | |
| Haudenschild et al. | Differential expression of multiple genes during articular chondrocyte redifferentiation | |
| Robinson et al. | MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research | |
| GB2409274A (en) | Trap-tagging: a novel method for the identification and purification of RNA-protein complexes | |
| Tufan et al. | Frizzled‐7 and limb mesenchymal chondrogenesis: Effect of misexpression and involvement of N‐cadherin | |
| Vanwetswinkel et al. | Selection of β-lactamases and penicillin binding mutants from a library of phage displayed TEM-1 β-lactamase randomly mutated in the active site Ω-loop | |
| Halim et al. | Regulation of the human MAT2A gene encoding the catalytic α2 subunit of methionine adenosyltransferase, MAT II: gene organization, promoter characterization, and identification of a site in the proximal promoter that is essential for its activity | |
| KR20150069375A (ko) | 줄기세포로부터 연골세포로의 분화 촉진용 조성물 | |
| Takahashi et al. | Effects of osteogenic induction on mesenchymal cells from fetal and maternal parts of human placenta | |
| Pisano et al. | Molecular fingerprinting of TGFß‐treated embryonic maxillary mesenchymal cells | |
| Traianedes et al. | Modulation of the signal recognition particle 54-kDa subunit (SRP54) in rat preosteoblasts by the extracellular matrix | |
| JP2022023684A (ja) | イヌ間葉系幹細胞培養用培地、イヌ間葉系幹細胞の培養方法及びイヌ間葉系幹細胞の製造方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1407787 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |