ATE420847T1 - Substituiertes phenylalkansäurederivat und dessen verwendung - Google Patents

Substituiertes phenylalkansäurederivat und dessen verwendung

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Publication number
ATE420847T1
ATE420847T1 AT03706983T AT03706983T ATE420847T1 AT E420847 T1 ATE420847 T1 AT E420847T1 AT 03706983 T AT03706983 T AT 03706983T AT 03706983 T AT03706983 T AT 03706983T AT E420847 T1 ATE420847 T1 AT E420847T1
Authority
AT
Austria
Prior art keywords
group
carbon atoms
alkyl group
substituted
phenylalkanic
Prior art date
Application number
AT03706983T
Other languages
English (en)
Inventor
Motoshi Shoda
Hiroshi Kuriyama
Original Assignee
Asahi Kasei Pharma Corp
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Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Application granted granted Critical
Publication of ATE420847T1 publication Critical patent/ATE420847T1/de

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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • C07C59/40—Unsaturated compounds
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    • C07—ORGANIC CHEMISTRY
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    • C07C59/40—Unsaturated compounds
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    • C07D209/04—Indoles; Hydrogenated indoles
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AT03706983T 2002-02-21 2003-02-20 Substituiertes phenylalkansäurederivat und dessen verwendung ATE420847T1 (de)

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ES2319753T3 (es) * 2002-02-21 2009-05-12 Asahi Kasei Pharma Corporation Derivado del acido fenilalcanoico sustituido y utilizacion del mismo.
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
US7960369B2 (en) 2002-11-08 2011-06-14 Takeda Pharmaceutical Company Limited Receptor function regulator
KR101106631B1 (ko) * 2003-02-13 2012-01-20 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
WO2005016862A1 (en) * 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
JP4922615B2 (ja) * 2003-11-26 2012-04-25 武田薬品工業株式会社 受容体機能調節剤
EP1720855A4 (de) * 2004-03-02 2008-12-17 Smithkline Beecham Corp Hemmer der akt aktivität
GB0409921D0 (en) * 2004-05-04 2004-06-09 Novartis Ag Organic compounds
TW200716588A (en) * 2005-06-02 2007-05-01 Kyowa Hakko Kogyo Kk A process for preparing dibenzoxepin derivative
US7405302B2 (en) * 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
DK2045244T3 (da) 2006-07-20 2013-04-15 Asahi Kasei Pharma Corp Hidtil ukendt krystal af substitueret phenylalkansyre og fremstillingsfremgangsmåde
CL2008000973A1 (es) * 2007-04-05 2009-01-02 Astrazeneca Ab Compuestos derivados de 1-oxo-isoquinolina; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento de enfermedades pulmonares obstructvas crónicas (epoc) y asma.
WO2008139879A1 (ja) * 2007-04-26 2008-11-20 Pharmafrontier, Co., Ltd. Ｇ蛋白質共役型レセプター抑制剤および医薬
AU2008282728B2 (en) * 2007-08-02 2012-04-19 Amgen Inc. Pl3 kinase modulators and methods of use
WO2009091017A1 (ja) * 2008-01-18 2009-07-23 Asahi Kasei Pharma Corporation 安定な医薬組成物
CA2722102C (en) * 2008-04-28 2013-06-11 Asahi Kasei Pharma Corporation Phenylpropionic acid derivative and use thereof
PL2292592T3 (pl) 2008-06-05 2013-01-31 Asahi Kasei Pharma Corp Związki sulfonamidowe i ich zastosowanie
CN102391264A (zh) * 2011-09-21 2012-03-28 河北九派制药有限公司 6-溴咪唑并[1,2-a]吡啶的制备方法
JP5802518B2 (ja) 2011-10-31 2015-10-28 公益財団法人微生物化学研究会 新規化合物、その製造方法、及びその用途
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
CN105315167A (zh) * 2014-08-01 2016-02-10 华东师范大学 一种2,2,3-三芳基-3-芳基氨基丙酸甲酯衍生物及其合成方法和应用
KR101829290B1 (ko) * 2014-12-24 2018-02-19 주식회사 엘지화학 Gpr120 효능제로서의 바이아릴 유도체
JP6635999B2 (ja) * 2017-10-13 2020-01-29 株式会社ダイセル カリウム塩の製造方法、及びカリウム塩
CN110092774B (zh) * 2018-01-29 2022-04-08 中国科学院上海药物研究所 芳香丙酸类衍生物、及其制备方法和用途
JP2024506909A (ja) * 2021-02-12 2024-02-15 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
WO2022187856A1 (en) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用

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JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
US6376546B1 (en) * 1997-10-14 2002-04-23 Asahi Kasei Kabushiki Kaisha Biphenyl-5-alkanoic acid derivatives and use thereof
ES2319753T3 (es) * 2002-02-21 2009-05-12 Asahi Kasei Pharma Corporation Derivado del acido fenilalcanoico sustituido y utilizacion del mismo.

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KR20040094712A (ko) 2004-11-10
CA2477208C (en) 2010-11-30
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AU2003211384B2 (en) 2008-12-11
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EP1477472A1 (de) 2004-11-17
CN100387576C (zh) 2008-05-14
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MXPA04008176A (es) 2004-11-26
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JP5048017B2 (ja) 2012-10-17
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AU2003211384A1 (en) 2003-09-09
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ES2319753T3 (es) 2009-05-12
PT1477472E (pt) 2009-03-17
JP2009167217A (ja) 2009-07-30
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